The histone deacetylase inhibitor, Trichostatin A, induces G2/M phase arrest and apoptosis inYD-10B oral squamous carcinoma cells

Oncology Reports

Volumn 27, Issue 2, 2012, Pages 455-460

  Anh, Trinh Duc ^a   Ahn, Mee Young ^a   Kim, Soo A ^b   Yoon, Jung Hoon ^a   Ahn, Sang Gun ^a  

^a Chosun University   (South Korea)

^b Dongguk University   (South Korea)

Author keywords

Apoptosis; Cell cycle; Histone deacetylases; Oral cancer; Trichostatin A

Indexed keywords

CASPASE 3; CASPASE 7; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; HISTONE DEACETYLASE; HISTONE H3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN TYROSINE PHOSPHATASE; TRICHOSTATIN A;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE G1 PHASE; CELL KILLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; EPIGENETICS; G2 PHASE CELL CYCLE CHECKPOINT; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; M PHASE CELL CYCLE CHECKPOINT; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUTH CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SQUAMOUS CELL CARCINOMA; UPREGULATION;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MOUTH NEOPLASMS;

EID: 84862915018     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1496     Document Type: Article

References (29)

1. Berger SL: The complex language of chromatin regulation during transcription. Nature 447: 407-412, 2007.
2. Ropero S and Esteller M: The role of histone deacetylases (HDACs) in human cancer. Mol Oncol 1: 19-25, 2007. (Pubitemid 46776612)
3. Shankar S and Srivastava RK: Histone deacetylase inhibitors: mechanisms and clinical significance in cancer: HDAC inhibitor-induced apoptosis. Adv Exp Med Biol 615: 261-298, 2008.
4. Moradei O, Vaisburg A and Martell RE: Histone deacetylase inhibitors in cancer therapy: new compounds and clinical update of benzamide-type agents. Curr Top Med Chem 8: 841-858, 2008. (Pubitemid 351984708)
5. Bolden JE, Peart MJ and Johnstone RW: Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5: 769-784, 2006. (Pubitemid 44348499)
6. Marks PA and Xu WS: Histone deacetylase inhibitors: potential in cancer therapy. J Cell Biochem 107: 600-608, 2009.
7. Yoshikawa M, Hishikawa K, Idei M and Fujita T: Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. Eur J Pharmacol 642: 28-36, 2010.
8. Yao J, Duan L, Fan M and Wu X: NF-kB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. Pharmacol Res 54: 406-413, 2006. (Pubitemid 46053815)
9. Pan L, Lu J, Wang X, Han L, Zhang Y, Han S and Huang B: Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. Cancer 109: 1676-1688, 2007. (Pubitemid 46595705)
10. Jang ER, Kim YJ, Myung SC, Kim W and Lee CS: Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. Mol Cell Biochem 353: 1-11, 2011.
11. Zhou C, Qiu L, Sun Y, Healey S, Wanebo H, Kouttab N, Di W, Yan B and Wan Y: Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. Int J Oncol 29: 269-278, 2006.
12. Kim HR, Kim EJ, Yang SH, Jeong ET, Park C, Lee JH, Youn MJ, So HS and Park R: Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway. Exp Mol Med 38: 616-624, 2006. (Pubitemid 46103583)
13. Noh EJ, Lim DS, Jeong G and Lee JS: An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. Biochem Biophys Res Commun 378: 326-331, 2009.
14. Nishioka C, Ikezoe T, Yang J, Koeffler HP and Yokoyama A: Inhibition of MEK/ERK signaling synergistically potentiates histone deacetylase inhibitor-induced growth arrest, apoptosis and acetylation of histone H3 on p21waf1 promoter in acute myelogenous leukemia cell. Leukemia 22: 1449-1452, 2008. (Pubitemid 352006093)
15. Wu ZQ, Zhang R, Chao C, Zhang JF and Zhang YQ: Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. Chin Med J (Engl) 120: 2112-2118, 2007. (Pubitemid 350268159)
16. Hajji N, Wallenborg K, Vlachos P, Nyman U, Hermanson O and Joseph B: Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. Oncogene 27: 3134-3144, 2008. (Pubitemid 351693171)
17. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
18. Massano J, Regateiro FS, Januário G and Ferreira A: Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102: 67-76, 2006. (Pubitemid 44016111)
19. Glover DM, Hagan IM and Tavares AA: Polo-like kinases: a team that plays throughout mitosis. Genes Dev 12: 3777-3787, 1998. (Pubitemid 29024839)
20. Donaldson MM, Tavares AA, Hagan IM, Nigg EA and Glover DM: The mitotic roles of Polo-like kinase. J Cell Sci 114: 2357-2358, 2001. (Pubitemid 32684791)
21. Liu XS, Song B and Liu X: The substrates of Plk1, beyond the functions in mitosis. Protein Cell 1: 999-1010, 2010.
22. Lens SM, Voest EE and Medema RH: Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer 10: 825-841, 2010.
23. Kim MS, Baek JH, Chakravarty D, Sidransky D and Carrier F: Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). Exp Cell Res 306: 94-102, 2005. (Pubitemid 40692775)
24. Acharya MR, Sparreboom A, Venitz J and Figg WD: Rational development of histone deacetylase inhibitors as anticancer agents: a review. Mol Pharmacol 68: 917-932, 2005. (Pubitemid 41345783)
25. Monneret C: Histone deacetylase inhibitors. Eur J Med Chem 40: 1-13, 2005.
26. Roh MS, Kim CW, Park BS, Kim GC, Jeong JH, Kwon HC, Suh DJ, Cho KH, Yee SB and Yoo YH: Mechanism of histone deacetylase inhibitor trichostatin A induced apoptosis in human osteosarcoma cells. Apoptosis 9: 583-589, 2004. (Pubitemid 39158634)
27. Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG and Schuppan D: The histone-deacetylase inhibitor trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol 36: 233-240, 2002. (Pubitemid 34146430)
28. Sawa H, Murakami H, Ohshima Y, Sugino T, Nakajyo T, Kisanuki T, Tamura Y, Satone A, Ide W, Hashimoto I and Kamada H: Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad. Brain Tumor Pathol 18: 109-114, 2001.
29. Shankar S, Singh TR, Fandy TE, Luetrakul T, Ross DD and Srivastava RK: Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: Involvement of both death receptor and mitochondrial pathways. Int J Mol Med 16: 1125-1138, 2005.