An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner

Biochemical and Biophysical Research Communications

Volumn 378, Issue 3, 2009, Pages 326-331

  Noh, Eun Joo ^a,b,c   Lim, Dae Sik ^b   Jeong, Gajin ^c   Lee, Jong Soo ^a  

^a Ajou University   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Cell cycle; Cell death; Histone deacetylase; Transcription; Trichostatin A

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE INHIBITOR 1; DACTINOMYCIN; POLO LIKE KINASE 1; SURVIVIN; TRICHOSTATIN A;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; CHROMOSOME SEGREGATION; CONTROLLED STUDY; ENZYME INHIBITION; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; SPINDLE POLE BODY; TRANSCRIPTION REGULATION;

APOPTOSIS; CELL CYCLE PROTEINS; CELL DIVISION; CELL PROLIFERATION; CHROMOSOME SEGREGATION; CYCLIN B; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME INHIBITORS; G2 PHASE; GENE EXPRESSION REGULATION; HELA CELLS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MITOTIC SPINDLE APPARATUS; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC;

EID: 57749189353     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.057     Document Type: Article

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