Structures of alkaloid biosynthetic glucosidases decode substrate specificity

ACS Chemical Biology

Volumn 7, Issue 1, 2012, Pages 226-234

  Xia, Liqun ^a   Ruppert, Martin ^b   Wang, Meitian ^c   Panjikar, Santosh ^d   Lin, Haili ^a   Rajendran, Chitra ^c   Barleben, Leif ^e   Stöckigt, Joachim ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

^d AUSTRALIAN SYNCHROTRON   (Australia)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

16 EPI VELLOSIMINE; AJMALINE; ALKALOID DERIVATIVE; DIHYDRO RAUCAFFRICINE; GLUCOSIDASE; LIGAND; RAUCAFFRICINE; RAUCAFFRICINE GLUCOSIDASE; SECOLOGANIN; SERINE; STRICTOSIDINE; STRICTOSIDINE GLUCOSIDASE; TRYPTAMINE; UNCLASSIFIED DRUG; VINORINE; VOMILENINE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAUWOLFIA; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; GLUCOSIDASES; IRIDOID GLUCOSIDES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; PROTEIN BINDING; RAUWOLFIA; SERINE; SUBSTRATE SPECIFICITY; TRYPTOPHAN; VINCA ALKALOIDS;

RAUVOLFIA;

EID: 84862913784     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb200267w     Document Type: Article

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