Structural basis and enzymatic mechanism of the biosynthesis of C 9from C10-monoterpenoid indole alkaloids

Angewandte Chemie - International Edition

Volumn 48, Issue 28, 2009, Pages 5211-5213

  Yang, Liuqing ^a,b   Hill, Marco ^b   Wang, Meitian ^c   Panjikar, Santosh ^d   Stöckigt, Joachim ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

^d DESY   (Germany)

Author keywords

Alkaloids; Biosynthesis; Enzyme catalysis; Esterases; Protein structures

Indexed keywords

ALKALOIDS; CATALYTIC TRIAD; ENZYMATIC MECHANISMS; ENZYME CATALYSIS; ESTERASES; HYDROLASES; MONOTERPENOID INDOLE ALKALOIDS; NEW MEMBERS; NOVEL FUNCTIONS; PROTEIN STRUCTURES; STRUCTURAL BASIS; THREE-DIMENSIONAL STRUCTURE;

ALDEHYDES; AMINO ACIDS; BIOCHEMISTRY; CATALYSIS; ENZYMES;

BIOSYNTHESIS;

CARBOXYLESTERASE; MUTANT PROTEIN; POLYNEURIDINE ALDEHYDE ESTERASE; RAUWOLFIA ALKALOID;

AMINO ACID SUBSTITUTION; BIOCATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; BIOCATALYSIS; CARBOXYLIC ESTER HYDROLASES; MUTANT PROTEINS; PROTEIN STRUCTURE, TERTIARY; SECOLOGANIN TRYPTAMINE ALKALOIDS; SUBSTRATE SPECIFICITY;

EID: 70349895349     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200900150     Document Type: Article

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