Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1043-1053

  Cash, Jennifer N ^a   Angerman, Elizabeth B ^a   Kattamuri, Chandramohan ^a   Nolan, Kristof ^a   Zhao, Huaying ^b   Sidis, Yisrael ^c   Keutmann, Henry T ^d   Thompson, Thomas B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL DIFFERENCES; EXTRACELLULAR; LIGAND BINDING; MOLECULAR MECHANISM; MUSCLE GROWTH; MYOSTATIN; N-TERMINAL DOMAINS; NEGATIVE REGULATORS; ONE-FORM; PHYSIOLOGICAL PROCESS; PROTEIN COMPLEXES; RECEPTOR BINDING; SINGLE-POINT MUTATION; THERAPEUTIC TARGETS;

GLYCOPROTEINS; LIGANDS; MOLECULES; MUSCLE;

CRYSTAL STRUCTURE;

ACTIVIN A; FOLLISTATIN LIKE 3; MYOSTATIN; PROTEIN INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING KINETICS; BINDING SITE; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; FOLLISTATIN-RELATED PROTEINS; HUMANS; MODELS, MOLECULAR; MYOSTATIN; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84862908549     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.270801     Document Type: Article

References (56)

1. Hayette, S., Gadoux, M., Martel, S., Bertrand, S., Tigaud, I., Magaud, J. P., and Rimokh, R. (1998) Oncogene 16, 2949-2954
2. Ueno, N., Ling, N., Ying, S. Y., Esch, F., Shimasaki, S., and Guillemin, R. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 8282-8286
3. Matzuk, M. M., Lu, N., Vogel, H., Sellheyer, K., Roop, D. R., and Bradley, A. (1995) Nature 374, 360-363
4. Mukherjee, A., Sidis, Y., Mahan, A., Raher, M. J., Xia, Y., Rosen, E. D., Bloch, K. D., Thomas, M. K., and Schneyer, A. L. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 1348-1353
5. Shimano, M., Ouchi, N., Nakamura, K., Oshima, Y., Higuchi, A., Pimentel, D. R., Panse, K. D., Lara-Pezzi, E., Lee, S. J., Sam, F., and Walsh, K. (2011) J. Biol. Chem. 286, 9840-9848
6. Sidis, Y., Mukherjee, A., Keutmann, H., Delbaere, A., Sadatsuki, M., and Schneyer, A. (2006) Endocrinology 147, 3586-3597
7. Innis, C. A., Shi, J., and Blundell, T. L. (2000) Protein Eng. 13, 839-847
8. Keller, S., Nickel, J., Zhang, J. L., Sebald, W., and Mueller, T. D. (2004) Nat. Struct. Mol. Biol. 11, 481-488
9. Korupolu, R. V., Muenster, U., Read, J. D., Vale, W., and Fischer, W. H. (2008) J. Biol. Chem. 283, 3782-3790
10. Kotzsch, A., Nickel, J., Seher, A., Sebald, W., and Muller, T. D. (2009) EMBO J. 28, 937-947
11. Nickel, J., Kotzsch, A., Sebald, W., and Mueller, T. D. (2005) J. Mol. Biol. 349, 933-947
12. Cash, J. N., Rejon, C. A., McPherron, A. C., Bernard, D. J., and Thompson, T. B. (2009) EMBO J. 28, 2662-2676
13. Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., and Bradley, A. (1995) Nature 374, 354-356
14. Xia, Y., and Schneyer, A. L. (2009) J. Endocrinol. 202, 1-12
15. McPherron, A. C., Lawler, A. M., and Lee, S. J. (1997) Nature 387, 83-90
16. Lee, S. J. (2004) Annu. Rev. Cell Dev. Biol. 20, 61-86
17. Lee, S. J. (2010) Immunology, endocrine & metabolic agents in medicinal chemistry 10, 183-194
18. Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P., Esquela, A. F., Tomkinson, K. N., McPherron, A. C., Wolfman, N. M., and Lee, S. J. (2002) Science 296, 1486-1488
19. Bradley, L., Yaworsky, P., and Walsh, F. (2008) Cell. Mol. Life Sci. 65, 2119-2124
20. Tsuchida, K., Nakatani, M., Uezumi, A., Murakami, T., and Cui, X. (2008) Endocr. J. 55, 11-21
21. Nakatani, M., Takehara, Y., Sugino, H., Matsumoto, M., Hashimoto, O., Hasegawa, Y., Murakami, T., Uezumi, A., Takeda, S., Noji, S., Sunada, Y., and Tsuchida, K. (2008) FASEB J. 22, 477-487
22. Nakatani, M., Kokubo, M., Ohsawa, Y., Sunada, Y., and Tsuchida, K. (2011) Am. J. Physiol. Endocrinol. Metab. 300, E543-E553
23. Inouye, S., Ling, N., and Shimasaki, S. (1992) Mol. Cell. Endocrinol. 90, 1-6
24. Sidis, Y., Schneyer, A. L., and Keutmann, H. T. (2005) Endocrinology 146, 130-136
25. Stamler, R., Keutmann, H. T., Sidis, Y., Kattamuri, C., Schneyer, A., and Thompson, T. B. (2008) J. Biol. Chem. 283, 32831-32838
26. Hill, J. J., Davies, M. V., Pearson, A. A., Wang, J. H., Hewick, R. M., Wolfman, N. M., and Qiu, Y. (2002) J. Biol. Chem. 277, 40735-40741
27. Lerch, T. F., Shimasaki, S., Woodruff, T. K., and Jardetzky, T. S. (2007) J. Biol. Chem. 282, 15930-15939
28. Thompson, T. B., Lerch, T. F., Cook, R. W., Woodruff, T. K., and Jardetzky, T. S. (2005) Dev. Cell 9, 535-543
29. Harrington, A. E., Morris-Triggs, S. A., Ruotolo, B. T., Robinson, C. V., Ohnuma, S., and Hyvonen, M. (2006) EMBO J. 25, 1035-1045
30. Takehara-Kasamatsu, Y., Tsuchida, K., Nakatani, M., Murakami, T., Kurisaki, A., Hashimoto, O., Ohuchi, H., Kurose, H., Mori, K., Kagami, S., Noji, S., and Sugino, H. (2007) J. Med. Invest. 54, 276-288
31. Harrison, C. A., Chan, K. L., and Robertson, D. M. (2006) Endocrinology 147, 2744-2753
32. Keutmann, H. T., Schneyer, A. L., and Sidis, Y. (2004) Mol. Endocrinol. 18, 228-240
33. Schneyer, A. L., Sidis, Y., Gulati, A., Sun, J. L., Keutmann, H., and Krasney, P. A. (2008) Endocrinology 149, 4589-4595
34. Sidis, Y., Schneyer, A. L., Sluss, P. M., Johnson, L. N., and Keutmann, H. T. (2001) J. Biol. Chem. 276, 17718-17726
35. Lee, S. J., and McPherron, A. C. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 9306-9311
36. Jiang, M. S., Liang, L. F., Wang, S., Ratovitski, T., Holmstrom, J., Barker, C., and Stotish, R. (2004) Biochem. Biophys. Res. Commun. 315, 525-531
37. Thompson, T. B., Woodruff, T. K., and Jardetzky, T. S. (2003) EMBO J. 22, 1555-1566
38. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
39. McCoy, A., Grosse-Kunstleve, R., Adams, P., Winn, M., Storoni, L., and Read, R. (2007) J. Appl. Crystallogr. 40, 658-674
40. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. D Biol. Crystallogr. 53, 240-255
41. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
42. Painter, J., and Merritt, E. A. (2006) J. Appl. Crystallogr. 39, 109-111
43. Salerno, W. J., Seaver, S. M., Armstrong, B. R., and Radhakrishnan, I. (2004) Nucleic Acids Res. 32, W566-W568
44. Lawrence, M. C., and Colman, P. M. (1993) J. Mol. Biol. 234, 946-950
45. Davis, I., Leaver-Fay, A., Chen, V., Block, J., Kapral, G., Wang, X., Murray, L., Arendall, W., Snoeyink, J., Richardson, J., and Richardson, D. (2007) Nucleic Acids Res. 35, W375-W383
46. DeLano, W. L. (2002) PyMOL, DeLano Scientific, Palo Alto, CA, U.S.A.
47. Thies, R. S., Chen, T., Davies, M. V., Tomkinson, K. N., Pearson, A. A., Shakey, Q. A., and Wolfman, N. M. (2001) Growth Factors 18, 251-259
48. Schneyer, A. L., Rzucidlo, D. A., Sluss, P. M., and Crowley, W. F., Jr. (1994) Endocrinology 135, 667-674
49. Zhan, H., Sun, Z., and Matthews, K. S. (2009) Biochemistry 48, 1305-1314
50. Svitel, J., Balbo, A., Mariuzza, R. A., Gonzales, N. R., and Schuck, P. (2003) Biophys. J. 84, 4062-4077
51. Svitel, J., Boukari, H., Van Ryk, D., Willson, R. C., and Schuck, P. (2007) Biophys. J. 92, 1742-1758
52. Schuck, P., and Zhao, H. (2010) Methods Mol. Biol. 627, 15-54
53. Hart, P. J., Deep, S., Taylor, A. B., Shu, Z., Hinck, C. S., and Hinck, A. P. (2002) Nat. Struct. Biol. 9, 203-208
54. Greenwald, J., Vega, M. E., Allendorph, G. P., Fischer, W. H., Vale, W., and Choe, S. (2004) Mol. Cell 15, 485-489
55. Yang, M., Horii, K., Herr, A. B., and Kirley, T. L. (2008) Biochemistry 47, 771-778
56. Benfield, C. T., Mansur, D. S., McCoy, L. E., Ferguson, B. J., Bahar, M. W., Oldring, A. P., Grimes, J. M., Stuart, D. I., Graham, S. C., and Smith, G. L. (2011) J. Biol. Chem. 286, 20727-20735