Geranyl derivative of phloroacetophenone induces cancer cell-specific apoptosis through Bax-mediated mitochondrial pathway in MCF-7 human breast cancer cells

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 1, 2012, Pages 98-104

  Cho, Mi Yeon ^a   Park, Su Young ^a   Park, Sumin ^a   Lee, Yong Rok ^a   Han, Gi Dong ^a   Kim, Jung Ae ^a  

^a Yeungnam University   (South Korea)

Author keywords

Apoptosis; Bax; Cancer selective cytotoxicity; MCF 7; Phloroacetophenone

Indexed keywords

3 GERANYL 2,4,6 TRIHYDROXYACETOPHENONE; 3 PRENYL 2,4,6 TRIHYDROXYACETOPHENONE; ACETOPHENONE DERIVATIVE; CASPASE 3; CASPASE 7; CASPASE 9; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG; XANTHOHUMOL;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SPECIFICITY; ENZYME ACTIVATION; ENZYME RELEASE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SARCOMA CELL;

ACETOPHENONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASES; CELL LINE; CELL LINE, TUMOR; CYTOCHROMES C; FEMALE; FLAVONOIDS; HUMANS; INHIBITORY CONCENTRATION 50; MITOCHONDRIA; PHYTOTHERAPY; PLANT EXTRACTS; PROPIOPHENONES; PROTO-ONCOGENE PROTEINS C-BCL-2; SARCOMA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862908192     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.98     Document Type: Article

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