Novel polyphenol molecule isolated from licorice root (Glycrrhiza glabra) induces apoptosis, G2/M cell cycle arrest, and Bcl-2 phosphorylation in tumor cell lines

Journal of Agricultural and Food Chemistry

Volumn 50, Issue 4, 2002, Pages 677-684

  Rafi, Mohamed M ^a,d   Vastano, Bret C ^a   Zhu, Nanquan ^a   Ho, Chi Tang ^a,b   Ghai, Geetha ^a   Rosen, Robert T ^a,b   Gallo, Michael A ^b,d   DiPaola, Robert S ^c,d  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^d ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Bcl 2; Glycrrhiza glabra; Licorice; Microtubule

Indexed keywords

1 (2,4 DIHYDROXYPHENYL 4 O BETA DEXTRO GLUCOPYRANOSIDE) 3 HYDROXY 3 (4' HYDROXYPHENYL) 1 PROPANONE; 1 (2,4 DIHYDROXYPHENYL) 2 HYDROXY 3 (4' HYDROXYPHENYL) 1 PROPANONE; 1 (2,4 DIHYDROXYPHENYL) 3 HYDROXY 3 (4' HYDROXYPHENYL 4' O BETA DEXTRO GLUCOPYRANOSIDE) 1 PROPANONE; 1 (2,4 DIHYDROXYPHENYL) 3 HYDROXY 3 (4' HYDROXYPHENYL) 1 PROPANONE; 2,3,4 TRIHYDROXY 4' METHOXYCHALCONE; 2,4,4' TRIHYDROXYCHALCONE; CHALONE; GLYCYRRHIZA EXTRACT; HERBACEOUS AGENT; LIPOCORTIN 5; ONCOPROTEIN; PC SPES; PHENOL DERIVATIVE; POLYMER; POLYPHENOL DERIVATIVE; POLYPHENOLS; PROTEIN BCL 2; PROTO ONCOGENE PROTEINS C BCL 2; TESTOSTERONE; UNCLASSIFIED DRUG; FLAVONOID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOASSAY; CASTRATION; CELL CULTURE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL STRAIN MCF 7; CELL VIABILITY; CHEMISTRY; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; GLYCYRRHIZA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; METABOLISM; MICROTUBULE; MITOSIS; NEOPLASM; NICK END LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PHOSPHORYLATION; PLANT ROOT; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; ISOLATION AND PURIFICATION;

GLYCYRRHIZA; LIGUSTICUM; MINK CELL FOCUS-FORMING VIRUS;

APOPTOSIS; CELL CYCLE; FLAVONOIDS; G2 PHASE; GLYCYRRHIZA; MAGNETIC RESONANCE SPECTROSCOPY; MITOSIS; NEOPLASMS; PHENOLS; PHOSPHORYLATION; PLANT ROOTS; POLYMERS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0037070017     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf010774e     Document Type: Article

References (33)

1. Cancer patients use of nonproven therapy: A 5 year follow-up study
2. The chemopreventive properties of soy isoflavonoids in animal models of breast cancer
3. Clinical and biological activity of an estrogenic herbal combination (PC-SPES) in prostate cancer
4. Reduction of serum testosterone in men by licorice
5. Effects of a phytotherapeutic agent, PC-SPES, on prostate cancer: A preliminary investigation on human cell lines and patients
6. Antitumor effects of PC-SPES, an herbal formulation in prostate cancer
7. Regulation of androgen receptor (AR) and prostate specific antigen (PSA) expression in the androgen-responsive human prostate LNCaP cells by ethanolic extracts of the Chinese herbal preparation, PC-SPES
8. Double identity for proteins of the Bcl-2 family
9. Modulation of Bcl-2 and cytotoxicity by Licochalcone-A, a novel estrogenic flavonoid
10. Phase I clinical and pharmacologic study of 13-cis retinoic acid, alpha interferon and paclitaxel in patients with prostate cancer and other advanced malignancies
11. Tumor growth inhibition, apoptosis, and Bcl-2 down-regulation of MCF-7 ras tumors by sodium phenylacetate and tamoxifen combination
12. Taxol induces Bcl-2 phosphorylation and death of prostate cancer cells
13. Inactivation of Bcl-2 by phosphorylation
14. Bcl-2 is the guardian of microtubule integrity
15. Establishment and characterization of a new human prostatic carcinoma
16. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
17. Labeling DNA strand breaks with Brdu-UTP. Detection of apoptosis and cell proliferation
18. Evaluation of a soluble tetrazolium formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
19. The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells
20. Taxol induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
21. Phosphorylation of Bcl-2 is a marker of M phase events and not a determinent of apoptosis
22. Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis
23. Inhibitory effect of isoliquiritin, a compound in licorice root, on angio-genesis in vivo and tube formation in vitro
24. Antimicrobial agents from higher plants. Antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var. typica
25. Antioxidant constituants from licorice roots: Isolation, structure elucidation and antioxidative capacity toward LDL oxidation
26. The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria
27. Antitumorigenic chalcones
28. Licorice-induced hypertension and syndromes of apparent mineralcorticoid excess
29. Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells
30. Two polyphenol glycosides and tannins from Rosa Cymosa
31. Taxol stabilizes microtubules in mouse fibroblast cells
32. Chalcones: A new class of antimitotic agents
33. Interactions of colchicines with tubulin