Spatial immobilization of bone morphogenetic protein-4 in a collagen-PLGA hybrid scaffold for enhanced osteoinductivity

Biomaterials

Volumn 33, Issue 26, 2012, Pages 6140-6146

  Lu, Hongxu ^a   Kawazoe, Naoki ^a   Kitajima, Takashi ^b   Myoken, Yuka ^c   Tomita, Masahiro ^c   Umezawa, Akihiro ^d   Chen, Guoping ^a   Ito, Yoshihiro ^b  

^a NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c Immuno Biological Laboratories Co Ltd   (Japan)

^d NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

Bone morphogenetic protein 4; Bone regeneration; Collagen binding domain; Hybrid scaffold; Transgenic silkworms

Indexed keywords

BONE MORPHOGENETIC PROTEIN-4; BONE REGENERATION; COLLAGEN BINDING DOMAIN; HYBRID SCAFFOLDS; TRANSGENICS;

BIOMINERALIZATION; BONE; CELL ADHESION; COLLAGEN; GENE EXPRESSION; MOLECULAR BIOLOGY; STEM CELLS; THREE DIMENSIONAL;

SCAFFOLDS (BIOLOGY);

BONE MORPHOGENETIC PROTEIN 4; COLLAGEN; COLLAGEN BINDING PROTEIN; FIBRONECTIN; POLYGLYCOLIC ACID; TISSUE SCAFFOLD;

ANIMAL TISSUE; ARTICLE; BIOMINERALIZATION; BONE; CELL ADHESION; CELL CULTURE; CELL FUNCTION; CELL PROLIFERATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMOBILIZATION; IMPLANT; IN VIVO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; TISSUE ENGINEERING; UPREGULATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BOMBYX; BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; HUMANS; LACTIC ACID; MESENCHYMAL STEM CELLS; POLYGLYCOLIC ACID; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84862904296     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.05.038     Document Type: Article

References (27)

1. Hutmacher D.W. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000, 21:2529-2543.
2. Chen G., Sato T., Ohgushi H., Ushida T., Tateishi T., Tanaka J. Culturing of skin fibroblasts in a thin PLGA-collagen hybrid mesh. Biomaterials 2005, 26:2559-2566.
3. Chen G., Ushida T., Tateishi T. Hybrid biomaterials for tissue engineering: a preparative method for PLA or PLGA-collagen hybrid sponges. Adv Mater 2000, 12:455-457.
4. Hokugo A., Takamoto T., Tabata Y. Preparation of hybrid scaffold from fibrin and biodegradable polymer fiber. Biomaterials 2006, 27:61-67.
5. Reddi A.H. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 1998, 16:247-252.
6. Ugo R. Soluble osteogenic molecular signals and the induction of bone formation. Biomaterials 2006, 27:807-822.
7. Takahashi Y., Yamamoto M., Tabata Y. Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate. Biomaterials 2005, 26:4856-4865.
8. Shen H., Hu X., Yang F., Bei J., Wang S. The bioactivity of rhBMP-2 immobilized poly(lactide-co-glycolide) scaffolds. Biomaterials 2009, 30:3150-3157.
9. Lee J.H., Kim C.S., Choi K.H., Jung U.W., Yun J.H., Choi S.H., et al. The induction of bone formation in rat calvarial defects and subcutaneous tissues by recombinant human BMP-2, produced in E. coli. Biomaterials 2010, 31:3512-3519.
10. Pang E.K., Im S.U., Kim C.S., Choi S.H., Chai J.K., Kim C.K., et al. Effect of recombinant human bone morphogenetic protein-4 dose on bone formation in a rat calvarial defect model. J Periodontol 2004, 75:1364-1370.
11. Ohkawara N., Ueda H., Shinozaki S., Kitajima T., Ito Y., Asaoka H., et al. Hepatocyte growth factor fusion protein having collagen-binding activity (CBD-HGF) accelerates re-endothelialization and intimal hyperplasia in balloon-injured rat carotid artery. J Atheroscler Thromb 2007, 14:185-191.
12. Ishikawa T., Terai H., Kitajima T. Production of a biologically active epidermal growth factor fusion protein with high collagen affinity. J Biochem 2001, 129:627-633.
13. Tomita M., Hino R., Ogawa S., Iizuka M., Adachi T., Shimizu K., et al. A germline transgenic silkworm that secretes recombinant proteins in the sericin layer of cocoon. Transgenic Res 2007, 16:449-465.
14. Iizuka M., Tomita M., Shimizu K., Kikuchi Y., Yoshizato K. Translational enhancement of recombinant protein synthesis in transgenic silkworms by a 5'-untranslated region of polyhedrin gene of Bombyx mori Nucleopolyhedrovirus. J Biosci Bioeng 2008, 105:595-603.
15. Iizuka M., Ogawa S., Takeuchi A., Nakakita S., Kubo Y., Miyawaki Y., et al. Production of a recombinant mouse monoclonal antibody in transgenic silkworm cocoons. FEBS J 2009, 276:5806-5820.
16. Adachi T., Wang X., Murata T., Obara M., Akutsu H., Machida M., et al. Production of a non-triple helical collagen alpha chain in transgenic silkworms and its evaluation as a gelatin substitute for cell culture. Biotechnol Bioeng 2010, 106:860-870.
17. Kitajima T., Terai H., Ito Y. A fusion protein of hepatocyte growth factor for immobilization to collagen. Biomaterials 2007, 28:1989-1997.
18. Martin I., Jakob M., Schafer D., Dick W., Spagnoli G., Heberer M. Quantitative analysis of gene expression in human expression in human articular cartilage from normal and osteoarthritic joints. Osteoarthr Cartilage 2001, 9:112-118.
19. Schaefer J.F., Millham M.L., Crombrugghe B.D., Buckbinder L. FGF signaling antagonizes cytokine-mediated repression of sox9 in SW1353 chrondrosarcoma cells. Osteoarthr Cartilage 2003, 11:233-241.
20. Lee J., Choo J., Choi Y., Park J., Min D., Lee S., et al. Assembly of collagen-binding peptide with collagen as a bioactive scaffold for osteogenesis in vitro and in vivo. Biomaterials 2007, 28:4257-4267.
21. Chen B., Lin H., Zhao Y., Wang B., Zhao Y., Liu Y., et al. Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von Willebrand factor propolypeptide. J Biomed Mater Res A 2007, 80:428-434.
22. Han B., Perelman N., Tang B., Hall F., Shors E.C., Nimni M.E. Collagen-targeted BMP3 fusion proteins arrayed on collagen matrices or porous ceramics impregnated with Type I collagen enhance osteogenesis in a rat cranial defect model. J Orthop Res 2002, 20:747-755.
23. Visser R., Arrabal P.M., Becerra J., Rinas U., Cifuentes M. The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo. Biomaterials 2009, 30:2032-2037.
24. Nishi N., Matsushita O., Yuube K., Miyanaka H., Okabe A., Wada F. Collagen-binding growth factors: production and characterization of functional fusion proteins having a collagen-binding domain. Proc Natl Acad Sci USA 1998, 95:7018-7023.
25. Chen B., Lin H., Wang J., Zhao Y., Wang B., Zhao W., et al. Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2. Biomaterials 2007, 28:1027-1035.
26. Meinel L., Hofmann S., Betz O., Fajardo R., Merkle H.P., Langer R., et al. Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: comparison of adenovirus mediated gene transfer and protein delivery of BMP-2. Biomaterials 2006, 27:4993-5002.
27. Akman A.C., Seda T.R., Gumusderelioglu M., Nohutcu R.M. Bone morphogenetic protein-6-loaded chitosan scaffolds enhance the osteoblastic characteristics of MC3T3-E1 cells. Artif Organs 2010, 34:65-74.