Collagen-targeted BMP3 fusion proteins arrayed on collagen matrices or porous ceramics impregnated with type I collagen enhance osteogenesis in a rat cranial defect model

Journal of Orthopaedic Research

Volumn 20, Issue 4, 2002, Pages 747-755

  Han, Bo ^a   Perelman, Natalya ^a   Tang, Baowei ^a   Hall, Fredrick ^a   Shors, Edwin C ^a,b   Nimni, Marcel E ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Interpore Cross International   (United States)

Author keywords

Bone formation; Bone morphogenetic proteins; Extracellular matrix; Osteogenesis; Targeted growth factors; von Willebrand factor

Indexed keywords

BIOASSAY; BONE; CALCIFICATION (BIOCHEMISTRY); CERAMIC MATERIALS; COLLAGEN; ESCHERICHIA COLI; GENETIC ENGINEERING; IMPLANTS (SURGICAL); IMPREGNATION; NEUROLOGY; REDOX REACTIONS;

BIODISTRIBUTION;

PHYSIOLOGICAL MODELS;

COLLAGEN TYPE 1; HYBRID PROTEIN; OSTEOGENIN; RECOMBINANT PROTEIN; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CALCINOSIS; CELL INCLUSION; CERAMICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG ACTIVITY; ESCHERICHIA COLI; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMPLANTATION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OSSIFICATION; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN TARGETING; RAT; SKULL DEFECT;

ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIVISION; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; OSTEOGENESIS; RATS; RATS, INBRED F344; RECOMBINANT FUSION PROTEINS; SKULL;

EID: 0036312308     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-0266(01)00157-7     Document Type: Article

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