메뉴 건너뛰기




Volumn 6, Issue 3, 2012, Pages 339-348

GUCY2C molecular staging personalizes colorectal cancer patient management

Author keywords

biomarker; colorectal cancer; guanylyl cyclase C; occult tumor burden; prediction; prognosis; quantitative reverse transcriptase PCR; racial disparities; staging

Indexed keywords

BIOLOGICAL MARKER; PROTEIN GUCY2C; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84862899607     PISSN: 17520363     EISSN: 17520371     Source Type: Journal    
DOI: 10.2217/bmm.12.24     Document Type: Review
Times cited : (6)

References (121)
  • 1
    • 33750970026 scopus 로고    scopus 로고
    • The prognostic effect of micrometastases in previously staged lymph node negative (N0) colorectal carcinoma: A meta-analysis
    • Iddings D, Ahmad A, Elashoff D, Bilchik A. The prognostic effect of micrometastases in previously staged lymph node negative (N0) colorectal carcinoma: a meta-analysis. Ann. Surg. Oncol. 13(11), 1386-1392 (2006).
    • (2006) Ann. Surg. Oncol. , vol.13 , Issue.11 , pp. 1386-1392
    • Iddings, D.1    Ahmad, A.2    Elashoff, D.3    Bilchik, A.4
  • 2
    • 51849135486 scopus 로고    scopus 로고
    • Previstage™ GCC test for staging patients with colorectal cancer
    • Mejia A, Waldman S. Previstage™ GCC test for staging patients with colorectal cancer. Expert Rev. Mol. Diag. 8, 571-578 (2008).
    • (2008) Expert Rev. Mol. Diag. , vol.8 , pp. 571-578
    • Mejia, A.1    Waldman, S.2
  • 4
    • 36348943451 scopus 로고    scopus 로고
    • Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature
    • Nicastri DG, Doucette JT, Godfrey TE, Hughes SJ. Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. J. Mol. Diagn. 9(5), 563-571 (2007).
    • (2007) J. Mol. Diagn. , vol.9 , Issue.5 , pp. 563-571
    • Nicastri, D.G.1    Doucette, J.T.2    Godfrey, T.E.3    Hughes, S.J.4
  • 5
    • 80052028980 scopus 로고    scopus 로고
    • Use of inflammatory markers to guide cancer treatment
    • Clarke SJ, Chua W, Moore M et al. Use of inflammatory markers to guide cancer treatment. Clin. Pharmacol. Ther. 90(3), 475-478 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.90 , Issue.3 , pp. 475-478
    • Clarke, S.J.1    Chua, W.2    Moore, M.3
  • 6
    • 85027937688 scopus 로고    scopus 로고
    • National Cancer Policy Summit: Addressing opportunities and challenges in cancer care and research
    • Nass SJ, Balogh E. National Cancer Policy Summit: addressing opportunities and challenges in cancer care and research. Clin. Pharmacol. Ther. 89(6), 770-771 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , Issue.6 , pp. 770-771
    • Nass, S.J.1    Balogh, E.2
  • 9
    • 85027935630 scopus 로고    scopus 로고
    • Pharmacogenetic testing: Time for clinical practice guidelines
    • Amstutz U, Carleton BC. Pharmacogenetic testing: time for clinical practice guidelines. Clin. Pharmacol. Ther. 89(6), 924-927 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , Issue.6 , pp. 924-927
    • Amstutz, U.1    Carleton, B.C.2
  • 10
    • 79959487599 scopus 로고    scopus 로고
    • Practical ethics: Establishing a pathway to benefit for complex pharmacogenomic tests
    • Haga SB, Burke W. Practical ethics: establishing a pathway to benefit for complex pharmacogenomic tests. Clin. Pharmacol. Ther. 90(1), 25-27 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.90 , Issue.1 , pp. 25-27
    • Haga, S.B.1    Burke, W.2
  • 13
    • 11344286311 scopus 로고    scopus 로고
    • The staging of colorectal cancer: 2004 and beyond
    • Compton CC, Greene FL. The staging of colorectal cancer: 2004 and beyond. CA Cancer J. Clin. 54(6), 295-308 (2004).
    • (2004) CA Cancer J. Clin. , vol.54 , Issue.6 , pp. 295-308
    • Compton, C.C.1    Greene, F.L.2
  • 15
    • 13744251436 scopus 로고    scopus 로고
    • Systemic therapy for colorectal cancer
    • Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N. Engl. J. Med. 352(5), 476-487 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , Issue.5 , pp. 476-487
    • Meyerhardt, J.A.1    Mayer, R.J.2
  • 16
    • 0034656999 scopus 로고    scopus 로고
    • The annual report to the nation on the status of cancer, 1973-1997, with a special section on colorectal cancer
    • Ries LA, Wingo PA, Miller DS et al. The annual report to the nation on the status of cancer, 1973-1997, with a special section on colorectal cancer. Cancer 88(10), 2398-2424 (2000).
    • (2000) Cancer , vol.88 , Issue.10 , pp. 2398-2424
    • Ries, L.A.1    Wingo, P.A.2    Miller, D.S.3
  • 17
    • 0034066520 scopus 로고    scopus 로고
    • New directions in the treatment of colorectal cancer: A look to the future
    • Sobrero A, Kerr D, Glimelius B et al. New directions in the treatment of colorectal cancer: a look to the future. Eur. J. Cancer 36(5), 559-566 (2000).
    • (2000) Eur. J. Cancer , vol.36 , Issue.5 , pp. 559-566
    • Sobrero, A.1    Kerr, D.2    Glimelius, B.3
  • 19
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • Andre T, Boni C, Mounedji-Boudiaf L et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N. Engl. J. Med. 350(23), 2343-2351 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , Issue.23 , pp. 2343-2351
    • Andre, T.1    Boni, C.2    Mounedji-Boudiaf, L.3
  • 20
    • 34748814911 scopus 로고    scopus 로고
    • Prognostic impact of micrometastases in colon cancer: Interim results of a prospective multicenter trial
    • discussion 575-567
    • Bilchik AJ, Hoon DS, Saha S et al. Prognostic impact of micrometastases in colon cancer: interim results of a prospective multicenter trial. Ann. Surg. 246(4), 568-575; discussion 575-567 (2007).
    • (2007) Ann. Surg. , vol.246 , Issue.4 , pp. 568-575
    • Bilchik, A.J.1    Hoon, D.S.2    Saha, S.3
  • 21
    • 0032949446 scopus 로고    scopus 로고
    • Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four national surgical adjuvant breast and bowel project adjuvant studies (C-01, C-02, C-03, and C-04)
    • Mamounas E, Wieand S, Wolmark N et al. Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four national surgical adjuvant breast and bowel project adjuvant studies (C-01, C-02, C-03, and C-04). J. Clin. Oncol. 17(5), 1349-1355 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , Issue.5 , pp. 1349-1355
    • Mamounas, E.1    Wieand, S.2    Wolmark, N.3
  • 22
    • 36849064682 scopus 로고    scopus 로고
    • Adjuvant chemotherapy versus observation in patients with colorectal cancer: A randomised study
    • Quasar Collaborative Group, Gray R, Barnwell J et al. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet 370(9604), 2020-2029 (2007).
    • (2007) Lancet , vol.370 , Issue.9604 , pp. 2020-2029
    • Gray, R.1    Barnwell, J.2
  • 23
    • 38149057533 scopus 로고    scopus 로고
    • The biologic significance of micrometastatic disease and sentinel lymph node technology on colorectal cancer
    • Iddings D, Bilchik A The biologic significance of micrometastatic disease and sentinel lymph node technology on colorectal cancer. J. Surg. Oncol. 96(8), 671-677 (2007).
    • (2007) J Surg. Oncol. , vol.96 , Issue.8 , pp. 671-677
    • Iddings, D.1    Bilchik, A.2
  • 24
    • 0032972185 scopus 로고    scopus 로고
    • Accurate lymph-node detection in colorectal specimens resected for cancer is of prognostic significance
    • discussion 154-148
    • Ratto C, Sofo L, Ippoliti M et al. Accurate lymph-node detection in colorectal specimens resected for cancer is of prognostic significance. Dis. Colon Rectum 42(2), 143-154; discussion 154-148 (1999).
    • (1999) Dis. Colon Rectum , vol.42 , Issue.2 , pp. 143-154
    • Ratto, C.1    Sofo, L.2    Ippoliti, M.3
  • 25
    • 0026535869 scopus 로고
    • Patterns of recurrence after curative resection of carcinoma of the colon and rectum
    • Galandiuk S, Wieand HS, Moertel CG et al. Patterns of recurrence after curative resection of carcinoma of the colon and rectum. Surg. Gynecol. Obstet. 174(1), 27-32 (1992).
    • (1992) Surg. Gynecol. Obstet. , vol.174 , Issue.1 , pp. 27-32
    • Galandiuk, S.1    Wieand, H.S.2    Moertel, C.G.3
  • 26
    • 0028010876 scopus 로고
    • Identification of occult micrometastases in pericolic lymph nodes of Duke's B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival
    • Greenson JK, Isenhart CE, Rice R, Mojzisik C, Houchens D, Martin EW Jr. Identification of occult micrometastases in pericolic lymph nodes of Duke's B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival. Cancer 73(3), 563-569 (1994).
    • (1994) Cancer , vol.73 , Issue.3 , pp. 563-569
    • Greenson, J.K.1    Isenhart, C.E.2    Rice, R.3    Mojzisik, C.4    Houchens, D.5    Martin Jr., E.W.6
  • 27
    • 0032560733 scopus 로고    scopus 로고
    • Micrometastases and survival in stage II colorectal cancer
    • Liefers GJ, Cleton-Jansen AM, van de Velde CJ et al. Micrometastases and survival in stage II colorectal cancer. N. Engl. J. Med. 339(4), 223-228 (1998).
    • (1998) N. Engl. J. Med. , vol.339 , Issue.4 , pp. 223-228
    • Liefers, G.J.1    Cleton-Jansen, A.M.2    Van De Velde, C.J.3
  • 28
    • 33646589659 scopus 로고    scopus 로고
    • Current issues in adjuvant treatment of stage II colon cancer
    • Andre T, Sargent D, Tabernero J et al. Current issues in adjuvant treatment of stage II colon cancer. Ann. Surg. Oncol. 13(6), 887-898 (2006).
    • (2006) Ann. Surg. Oncol. , vol.13 , Issue.6 , pp. 887-898
    • Andre, T.1    Sargent, D.2    Tabernero, J.3
  • 31
    • 0028809871 scopus 로고
    • Adjuvant chemotherapy for colon and rectal cancer
    • Fuchs CS, Mayer RJ. Adjuvant chemotherapy for colon and rectal cancer. Semin. Oncol. 22(5), 472-487 (1995).
    • (1995) Semin. Oncol. , vol.22 , Issue.5 , pp. 472-487
    • Fuchs, C.S.1    Mayer, R.J.2
  • 32
    • 0026071185 scopus 로고
    • Effective surgical adjuvant therapy for high-risk rectal carcinoma
    • Krook JE, Moertel CG, Gunderson LL et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N. Engl. J. Med. 324(11), 709-715 (1991).
    • (1991) N. Engl. J. Med. , vol.324 , Issue.11 , pp. 709-715
    • Krook, J.E.1    Moertel, C.G.2    Gunderson, L.L.3
  • 33
    • 0025060806 scopus 로고
    • Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma
    • Moertel CG, Fleming TR, Macdonald JS et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N. Engl. J. Med. 322(6), 352-358 (1990).
    • (1990) N. Engl. J. Med. , vol.322 , Issue.6 , pp. 352-358
    • Moertel, C.G.1    Fleming, T.R.2    MacDonald, J.S.3
  • 34
    • 0027436244 scopus 로고
    • The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from national surgical adjuvant breast and bowel project protocol C-03
    • Wolmark N, Rockette H, Fisher B et al. The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from national surgical adjuvant breast and bowel project protocol C-03. J. Clin. Oncol. 11(10), 1879-1887 (1993).
    • (1993) J. Clin. Oncol. , vol.11 , Issue.10 , pp. 1879-1887
    • Wolmark, N.1    Rockette, H.2    Fisher, B.3
  • 35
    • 68949094312 scopus 로고    scopus 로고
    • Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy
    • Kopetz S, Chang GJ, Overman MJ et al. improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J. Clin. Oncol. 27(22), 3677-3683 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.22 , pp. 3677-3683
    • Kopetz, S.1    Chang, G.J.2    Overman, M.J.3
  • 36
    • 60849123935 scopus 로고    scopus 로고
    • Evidence for cure by adjuvant therapy in colon cancer: Observations based on individual patient data from 20,898 patients on 18 randomized trials
    • Sargent D, Sobrero A, Grothey A et al. Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials. J. Clin. Oncol. 27(6), 872-877 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.6 , pp. 872-877
    • Sargent, D.1    Sobrero, A.2    Grothey, A.3
  • 37
    • 4344587783 scopus 로고    scopus 로고
    • American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer
    • Benson AB 3rd, Schrag D, Somerfield MR et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J. Clin. Oncol. 22(16), 3408-3419 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.16 , pp. 3408-3419
    • Benson, A.B.1    Schrag, D.2    Somerfield, M.R.3
  • 38
    • 4344591790 scopus 로고    scopus 로고
    • Adjuvant therapy for stage II colon cancer: A systematic review from the cancer care ontario program in evidence-based care's gastrointestinal cancer disease site group
    • Figueredo A, Charette ML, Maroun J, Brouwers MC, Zuraw L. Adjuvant therapy for stage II colon cancer: a systematic review from the cancer care ontario program in evidence-based care's gastrointestinal cancer disease site group. J. Clin. Oncol. 22(16), 3395-3407 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.16 , pp. 3395-3407
    • Figueredo, A.1    Charette, M.L.2    Maroun, J.3    Brouwers, M.C.4    Zuraw, L.5
  • 39
    • 79959310058 scopus 로고    scopus 로고
    • The NCCN clinical practice guidelines in oncology
    • Winn R, McClure J. The NCCN clinical practice guidelines in oncology. J. Natl Compr. Canc. Netw. 1(9), 5-13 (2003).
    • (2003) J. Natl Compr. Canc. Netw. , vol.1 , Issue.9 , pp. 5-13
    • Winn, R.1    McClure, J.2
  • 40
    • 25144465969 scopus 로고    scopus 로고
    • Guanylyl cyclase C: A molecular marker for staging and postoperative surveillance of patients with colorectal cancer
    • Frick GS, Pitari GM, Weinberg DS, Hyslop T, Schulz S, Waldman SA. Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancer. Expert Rev. Mol. Diagn. 5(5), 701-713 (2005).
    • (2005) Expert Rev. Mol. Diagn. , vol.5 , Issue.5 , pp. 701-713
    • Frick, G.S.1    Pitari, G.M.2    Weinberg, D.S.3    Hyslop, T.4    Schulz, S.5    Waldman, S.A.6
  • 42
    • 60749102639 scopus 로고    scopus 로고
    • Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer
    • Waldman SA, Hyslop T, Schulz S et al. Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer. JAMA 301(7), 745-752 (2009).
    • (2009) JAMA , vol.301 , Issue.7 , pp. 745-752
    • Waldman, S.A.1    Hyslop, T.2    Schulz, S.3
  • 43
    • 0033534114 scopus 로고    scopus 로고
    • Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer
    • Cagir B, Gelmann A, Park J et al. Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer. Ann. Intern. Med. 131(11), 805-812 (1999).
    • (1999) Ann. Intern. Med. , vol.131 , Issue.11 , pp. 805-812
    • Cagir, B.1    Gelmann, A.2    Park, J.3
  • 44
    • 0027180713 scopus 로고
    • Ligand-based histochemical localization and capture of cells expressing heat-stable enterotoxin receptors
    • Almenoff JS, Williams SI, Scheving LA, Judd AK, Schoolnik GK. Ligand-based histochemical localization and capture of cells expressing heat-stable enterotoxin receptors. Mol. Microbiol. 8(5), 865-873 (1993).
    • (1993) Mol. Microbiol. , vol.8 , Issue.5 , pp. 865-873
    • Almenoff, J.S.1    Williams, S.I.2    Scheving, L.A.3    Judd, A.K.4    Schoolnik, G.K.5
  • 45
    • 0029856172 scopus 로고    scopus 로고
    • Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues
    • Carrithers SL, Barber MT, Biswas S et al. Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues. Proc. Natl Acad. Sci. USA 93(25), 14827-14832 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , Issue.25 , pp. 14827-14832
    • Carrithers, S.L.1    Barber, M.T.2    Biswas, S.3
  • 47
    • 0023832678 scopus 로고
    • Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children
    • Cohen MB, Guarino A, Shukla R, Giannella RA. Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children. Gastroenterology 94(2), 367-373 (1988).
    • (1988) Gastroenterology , vol.94 , Issue.2 , pp. 367-373
    • Cohen, M.B.1    Guarino, A.2    Shukla, R.3    Giannella, R.A.4
  • 48
    • 0022639213 scopus 로고
    • The immature rat small intestine exhibits an increased sensitivity and response to Escherichia coli heat-stable enterotoxin
    • Cohen MB, Moyer MS, Luttrell M, Giannella RA. The immature rat small intestine exhibits an increased sensitivity and response to Escherichia coli heat-stable enterotoxin. Pediatr. Res. 20(6), 555-560 (1986).
    • (1986) Pediatr. Res. , vol.20 , Issue.6 , pp. 555-560
    • Cohen, M.B.1    Moyer, M.S.2    Luttrell, M.3    Giannella, R.A.4
  • 49
    • 0023610824 scopus 로고
    • T84 cell receptor binding and guanyl cyclase activation by Escherichia coli heat-stable toxin
    • Guarino A, Cohen M, Thompson M, Dharmsathaphorn K, Giannella R. T84 cell receptor binding and guanyl cyclase activation by Escherichia coli heat-stable toxin. Am. J. Physiol. 253(6 Pt 1), G775-G780 (1987).
    • (1987) Am. J. Physiol. , vol.253 , Issue.6 PART 1
    • Guarino, A.1    Cohen, M.2    Thompson, M.3    Dharmsathaphorn, K.4    Giannella, R.5
  • 50
    • 0023198769 scopus 로고
    • Small and large intestinal guanylate cyclase activity in children: Effect of age and stimulation by Escherichia coli heat-stable enterotoxin
    • Guarino A, Cohen MB, Giannella RA. Small and large intestinal guanylate cyclase activity in children: effect of age and stimulation by Escherichia coli heat-stable enterotoxin. Pediatr. Res. 21(6), 551-555 (1987).
    • (1987) Pediatr. Res. , vol.21 , Issue.6 , pp. 551-555
    • Guarino, A.1    Cohen, M.B.2    Giannella, R.A.3
  • 51
    • 0023220836 scopus 로고
    • Binding of e coli heat-stable enterotoxin to rat intestinal brush borders and to basolateral membranes
    • Guarino A, Cohen MB, Overmann G, Thompson MR, Giannella RA. Binding of E. coli heat-stable enterotoxin to rat intestinal brush borders and to basolateral membranes. Dig. Dis. Sci. 32(9), 1017-1026 (1987).
    • (1987) Dig. Dis. Sci. , vol.32 , Issue.9 , pp. 1017-1026
    • Guarino, A.1    Cohen, M.B.2    Overmann, G.3    Thompson, M.R.4    Giannella, R.A.5
  • 52
    • 0033832073 scopus 로고    scopus 로고
    • Guanylyl cyclases and signaling by cyclic GMP
    • Lucas KA, Pitari GM, Kazerounian S et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol. Rev. 52(3), 375-414 (2000).
    • (2000) Pharmacol. Rev. , vol.52 , Issue.3 , pp. 375-414
    • Lucas, K.A.1    Pitari, G.M.2    Kazerounian, S.3
  • 53
    • 0019212138 scopus 로고
    • Mode of action of heat-stable Escherichia coli enterotoxin. Tissue and subcellular specificities and role of cyclic GMP
    • Rao MC, Guandalini S, Smith PL, Field M. Mode of action of heat-stable Escherichia coli enterotoxin. Tissue and subcellular specificities and role of cyclic GMP. Biochim. Biophys. Acta 632(1), 35-46 (1980).
    • (1980) Biochim. Biophys. Acta , vol.632 , Issue.1 , pp. 35-46
    • Rao, M.C.1    Guandalini, S.2    Smith, P.L.3    Field, M.4
  • 54
    • 0346732047 scopus 로고    scopus 로고
    • Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor
    • Carrithers SL, Ott CE, Hill MJ et al. Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. Kidney Int. 65(1), 40-53 (2004).
    • (2004) Kidney Int. , vol.65 , Issue.1 , pp. 40-53
    • Carrithers, S.L.1    Ott, C.E.2    Hill, M.J.3
  • 55
    • 0018298587 scopus 로고
    • Mechanisms of action of cholera and Escherichia coli enterotoxins
    • Field M. Mechanisms of action of cholera and Escherichia coli enterotoxins. Am. J. Clin. Nutr. 32(1), 189-196 (1979).
    • (1979) Am. J. Clin. Nutr. , vol.32 , Issue.1 , pp. 189-196
    • Field, M.1
  • 56
    • 0011155218 scopus 로고
    • Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine
    • Field M, Graf LH Jr, Laird WJ, Smith PL. Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc. Natl Acad. Sci. USA 75(6), 2800-2804 (1978).
    • (1978) Proc. Natl Acad. Sci. USA , vol.75 , Issue.6 , pp. 2800-2804
    • Field, M.1    Graf Jr., L.H.2    Laird, W.J.3    Smith, P.L.4
  • 57
    • 0018976238 scopus 로고
    • Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli: Studies of tissue specificity, potential receptors, and intermediates
    • Guerrant RL, Hughes JM, Chang B, Robertson DC, Murad F. Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli: studies of tissue specificity, potential receptors, and intermediates. J. Infect. Dis. 142(2), 220-228 (1980).
    • (1980) J. Infect. Dis. , vol.142 , Issue.2 , pp. 220-228
    • Guerrant, R.L.1    Hughes, J.M.2    Chang, B.3    Robertson, D.C.4    Murad, F.5
  • 58
    • 0018100207 scopus 로고
    • Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli
    • Hughes JM, Murad F, Chang B, Guerrant RL. Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli. Nature 271(5647), 755-756 (1978).
    • (1978) Nature , vol.271 , Issue.5647 , pp. 755-756
    • Hughes, J.M.1    Murad, F.2    Chang, B.3    Guerrant, R.L.4
  • 59
    • 0022637305 scopus 로고
    • Characterization of the receptor for heat-stable enterotoxin from Escherichia coli in rat intestine
    • Kuno T, Kamisaki Y, Waldman SA, Gariepy J, Schoolnik G, Murad F. Characterization of the receptor for heat-stable enterotoxin from Escherichia coli in rat intestine. J. Biol. Chem. 261(3), 1470-1476 (1986).
    • (1986) J. Biol. Chem. , vol.261 , Issue.3 , pp. 1470-1476
    • Kuno, T.1    Kamisaki, Y.2    Waldman, S.A.3    Gariepy, J.4    Schoolnik, G.5    Murad, F.6
  • 60
    • 0025647794 scopus 로고
    • Guanylyl cyclase is a heat-stable enterotoxin receptor
    • Schulz S, Green CK, Yuen PS, Garbers DL. Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell 63(5), 941-948 (1990).
    • (1990) Cell , vol.63 , Issue.5 , pp. 941-948
    • Schulz, S.1    Green, C.K.2    Yuen, P.S.3    Garbers, D.L.4
  • 61
    • 38349041719 scopus 로고    scopus 로고
    • Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine
    • Li P, Lin JE, Chervoneva I, Schulz S, Waldman SA, Pitari GM. Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Am. J. Pathol. 171(6), 1847-1858 (2007).
    • (2007) Am. J. Pathol. , vol.171 , Issue.6 , pp. 1847-1858
    • Li, P.1    Lin, J.E.2    Chervoneva, I.3    Schulz, S.4    Waldman, S.A.5    Pitari, G.M.6
  • 62
    • 77953459477 scopus 로고    scopus 로고
    • Colorectal cancer as a paracrine deficiency syndrome amenable to oral hormone replacement therapy
    • Li P, Lin JE, Snook AE et al. Colorectal cancer as a paracrine deficiency syndrome amenable to oral hormone replacement therapy. Clin. Transl. Sci. 1, 163-167 (2008).
    • (2008) Clin. Transl. Sci. , vol.1 , pp. 163-167
    • Li, P.1    Lin, J.E.2    Snook, A.E.3
  • 63
    • 77955869895 scopus 로고    scopus 로고
    • Colorectal cancer is a paracrine deficiency syndrome which can be prevented and treated by oral hormone replacement therapy
    • Li P, Lin JE, Snook AE, Schulz S, Pitari GM, Waldman SA. Colorectal cancer is a paracrine deficiency syndrome which can be prevented and treated by oral hormone replacement therapy. Curr. Mol. Pharmacol. 2, 285-292 (2008
    • (2008) Curr. Mol. Pharmacol. , vol.2 , pp. 285-292
    • Li, P.1    Lin, J.E.2    Snook, A.E.3    Schulz, S.4    Pitari, G.M.5    Waldman, S.A.6
  • 64
    • 34547531854 scopus 로고    scopus 로고
    • Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity
    • Li P, Schulz S, Bombonati A et al. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology 133(2), 599-607 (2007).
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 599-607
    • Li, P.1    Schulz, S.2    Bombonati, A.3
  • 65
    • 67651227644 scopus 로고    scopus 로고
    • Guanylyl cyclase C in colorectal cancer: Susceptibility gene and potential therapeutic target
    • Lin JE, Li P, Pitari GM, Schulz S, Waldman SA. Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target. Future Oncol. 5(4), 509-522 (2009).
    • (2009) Future Oncol. , vol.5 , Issue.4 , pp. 509-522
    • Lin, J.E.1    Li, P.2    Pitari, G.M.3    Schulz, S.4    Waldman, S.A.5
  • 66
    • 84873484419 scopus 로고    scopus 로고
    • GUCY2C establishes lineage dependence in intestinal tumorigenesis through AKT
    • Lin JE, Li P, Snook AE et al. GUCY2C establishes lineage dependence in intestinal tumorigenesis through AKT. Gastroenterology 138, 241-254 (2008).
    • (2008) Gastroenterology , vol.138 , pp. 241-254
    • Lin, J.E.1    Li, P.2    Snook, A.E.3
  • 67
    • 28244432560 scopus 로고    scopus 로고
    • Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins
    • Pitari GM, Baksh RI, Harris DM, Li P, Kazerounian S, Waldman SA. Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins. Cancer Res. 65(23), 11129-11135 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.23 , pp. 11129-11135
    • Pitari, G.M.1    Baksh, R.I.2    Harris, D.M.3    Li, P.4    Kazerounian, S.5    Waldman, S.A.6
  • 68
    • 0034933794 scopus 로고    scopus 로고
    • Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells
    • Pitari GM, Di Guglielmo MD, Park J, Schulz S, Waldman SA. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Proc. Natl Acad. Sci. USA 98(14), 7846-7851 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , Issue.14 , pp. 7846-7851
    • Pitari, G.M.1    Di Guglielmo, M.D.2    Park, J.3    Schulz, S.4    Waldman, S.A.5
  • 69
    • 34548679603 scopus 로고    scopus 로고
    • The paracrine hormone hypothesis of colorectal cancer
    • Pitari GM, Li P, Lin JE et al. The paracrine hormone hypothesis of colorectal cancer. Clin. Pharmacol. Ther. 82(4), 441-447 (2007).
    • (2007) Clin. Pharmacol. Ther. , vol.82 , Issue.4 , pp. 441-447
    • Pitari, G.M.1    Li, P.2    Lin, J.E.3
  • 70
    • 49649106115 scopus 로고    scopus 로고
    • Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells
    • Pitari GM, Lin JE, Shah FJ et al. Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells. Carcinogenesis 29, 1601-1607 (2008).
    • (2008) Carcinogenesis , vol.29 , pp. 1601-1607
    • Pitari, G.M.1    Lin, J.E.2    Shah, F.J.3
  • 71
    • 0345701291 scopus 로고    scopus 로고
    • Bacterial enterotoxins are associated with resistance to colon cancer
    • Pitari GM, Zingman LV, Hodgson DM et al. Bacterial enterotoxins are associated with resistance to colon cancer. Proc. Natl Acad. Sci. USA 100(5), 2695-2699 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.5 , pp. 2695-2699
    • Pitari, G.M.1    Zingman, L.V.2    Hodgson, D.M.3
  • 72
    • 0034665151 scopus 로고    scopus 로고
    • Uroguanylin treatment suppresses polyp formation in the Apc (Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP
    • Shailubhai K, Yu HH, Karunanandaa K et al. Uroguanylin treatment suppresses polyp formation in the Apc (Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res. 60(18), 5151-5157 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.18 , pp. 5151-5157
    • Shailubhai, K.1    Yu, H.H.2    Karunanandaa, K.3
  • 73
    • 0036898023 scopus 로고    scopus 로고
    • Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation
    • Steinbrecher KA, Wowk SA, Rudolph JA, Witte DP, Cohen MB. Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation. Am. J. Pathol. 161(6), 2169-2178 (2002).
    • (2002) Am. J. Pathol. , vol.161 , Issue.6 , pp. 2169-2178
    • Steinbrecher, K.A.1    Wowk, S.A.2    Rudolph, J.A.3    Witte, D.P.4    Cohen, M.B.5
  • 75
    • 0031906877 scopus 로고    scopus 로고
    • Guanylin mRNA expression in human intestine and colorectal adenocarcinoma
    • Cohen MB, Hawkins JA, Witte DP. Guanylin mRNA expression in human intestine and colorectal adenocarcinoma. Laboratory Invest. 78(1), 101-108 (1998).
    • (1998) Laboratory Invest. , vol.78 , Issue.1 , pp. 101-108
    • Cohen, M.B.1    Hawkins, J.A.2    Witte, D.P.3
  • 76
    • 0035300437 scopus 로고    scopus 로고
    • Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays
    • Notterman DA, Alon U, Sierk AJ, Levine A. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res. 61(7), 3124-3130 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.7 , pp. 3124-3130
    • Notterman, D.A.1    Alon, U.2    Sierk, A.J.3    Levine, A.4
  • 77
    • 0034709572 scopus 로고    scopus 로고
    • Expression of guanylin is downregulated in mouse and human intestinal adenomas
    • Steinbrecher KA, Tuohy TM, Heppner Goss K et al. Expression of guanylin is downregulated in mouse and human intestinal adenomas. Biochem. Biophys. Res. Commun. 273(1), 225-230 (2000).
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , Issue.1 , pp. 225-230
    • Steinbrecher, K.A.1    Tuohy, T.M.2    Heppner Goss, K.3
  • 78
    • 84862867875 scopus 로고    scopus 로고
    • Silencing of guanylin and uroguanylin expression in colon cancer
    • Wilson C, Schulz S, Hyslop T, Waldman SA. Silencing of guanylin and uroguanylin expression in colon cancer. Expert Rev. Mol. Diagn. 9(8), 777-785 (2009).
    • (2009) Expert Rev. Mol. Diagn. , vol.9 , Issue.8 , pp. 777-785
    • Wilson, C.1    Schulz, S.2    Hyslop, T.3    Waldman, S.A.4
  • 79
    • 14644392242 scopus 로고    scopus 로고
    • Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract
    • Birbe R, Palazzo JP, Walters R, Weinberg D, Schulz S, Waldman SA. Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum. Pathol. 36(2), 170-179 (2005).
    • (2005) Hum. Pathol. , vol.36 , Issue.2 , pp. 170-179
    • Birbe, R.1    Palazzo, J.P.2    Walters, R.3    Weinberg, D.4    Schulz, S.5    Waldman, S.A.6
  • 80
    • 0035478543 scopus 로고    scopus 로고
    • Ectopic expression of guanylyl cyclase C in CD34+ progenitor cells in peripheral blood
    • Fava TA, Desnoyers R, Schulz S et al. Ectopic expression of guanylyl cyclase C in CD34+ progenitor cells in peripheral blood. J. Clin. Oncol. 19(19), 3951-3959 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , Issue.19 , pp. 3951-3959
    • Fava, T.A.1    Desnoyers, R.2    Schulz, S.3
  • 82
    • 0031938629 scopus 로고    scopus 로고
    • Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer
    • Waldman SA, Cagir B, Rakinic J et al. Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer. Dis. Colon Rectum 41(3), 310-315 (1998).
    • (1998) Dis. Colon Rectum , vol.41 , Issue.3 , pp. 310-315
    • Waldman, S.A.1    Cagir, B.2    Rakinic, J.3
  • 83
    • 33748070507 scopus 로고    scopus 로고
    • A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer
    • Schulz S, Hyslop T, Haaf J et al. A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer. Clin. Cancer Res. 12(15), 4545-4552 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.15 , pp. 4545-4552
    • Schulz, S.1    Hyslop, T.2    Haaf, J.3
  • 84
    • 29344458031 scopus 로고    scopus 로고
    • The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas
    • Witek ME, Nielsen K, Walters R et al. The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin. Cancer Res. 11(24 Pt 1), 8549-8556 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.24 PART 1 , pp. 8549-8556
    • Witek, M.E.1    Nielsen, K.2    Walters, R.3
  • 85
    • 77749326540 scopus 로고    scopus 로고
    • Analytical performance of a qRT-PCR assay to detect guanylyl cyclase C in FFPE lymph nodes of patients with colon cancer
    • Beaulieu M, Desaulniers M, Bertrand N et al. Analytical performance of a qRT-PCR assay to detect guanylyl cyclase C in FFPE lymph nodes of patients with colon cancer. Diagn. Mol. Pathol. 19(1), 20-27 (2010).
    • (2010) Diagn. Mol. Pathol. , vol.19 , Issue.1 , pp. 20-27
    • Beaulieu, M.1    Desaulniers, M.2    Bertrand, N.3
  • 86
    • 77953706553 scopus 로고    scopus 로고
    • Comparison of histopathology and RT-qPCR amplification of guanylyl cyclase C for detection of colon cancer metastases in lymph nodes
    • Haince JF, Houde M, Beaudry G et al. Comparison of histopathology and RT-qPCR amplification of guanylyl cyclase C for detection of colon cancer metastases in lymph nodes. J. Clin. Pathol. 63(6), 530-537 (2010).
    • (2010) J. Clin. Pathol. , vol.63 , Issue.6 , pp. 530-537
    • Haince, J.F.1    Houde, M.2    Beaudry, G.3
  • 87
    • 83055179767 scopus 로고    scopus 로고
    • Evaluation of guanylyl cyclase C lymph node status for colon cancer staging and prognosis
    • Sargent DJ, Resnick MB, Meyers MO et al. Evaluation of guanylyl cyclase C lymph node status for colon cancer staging and prognosis. Ann. Surg. Oncol. 18(12), 3261-3270 (2011).
    • (2011) Ann. Surg. Oncol. , vol.18 , Issue.12 , pp. 3261-3270
    • Sargent, D.J.1    Resnick, M.B.2    Meyers, M.O.3
  • 88
    • 77949437015 scopus 로고    scopus 로고
    • Colorectal cancer
    • Cunningham D, Atkin W, Lenz HJ et al. Colorectal cancer. Lancet 375(9719), 1030-1047 (2010).
    • (2010) Lancet , vol.375 , Issue.9719 , pp. 1030-1047
    • Cunningham, D.1    Atkin, W.2    Lenz, H.J.3
  • 90
    • 79955986146 scopus 로고    scopus 로고
    • Occult tumor burden predicts disease recurrence in lymph node-negative colorectal cancer
    • Hyslop T, Weinberg DS, Schulz S, Barkun A, Waldman SA. Occult tumor burden predicts disease recurrence in lymph node-negative colorectal cancer. Clin. Cancer Res. 17(10), 3293-3303 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.10 , pp. 3293-3303
    • Hyslop, T.1    Weinberg, D.S.2    Schulz, S.3    Barkun, A.4    Waldman, S.A.5
  • 91
    • 19944380505 scopus 로고    scopus 로고
    • Colorectal cancer and race: Understanding the differences in outcomes between African Americans and whites
    • Polite BN, Dignam JJ, Olopade OI. Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites. Med. Clin. North Am. 89(4), 771-793 (2005).
    • (2005) Med. Clin. North Am. , vol.89 , Issue.4 , pp. 771-793
    • Polite, B.N.1    Dignam, J.J.2    Olopade, O.I.3
  • 92
    • 33646598051 scopus 로고    scopus 로고
    • Colorectal cancer model of health disparities: Understanding mortality differences in minority populations
    • Polite BN, Dignam JJ, Olopade OI. Colorectal cancer model of health disparities: understanding mortality differences in minority populations. J. Clin. Oncol. 24(14), 2179-2187 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.14 , pp. 2179-2187
    • Polite, B.N.1    Dignam, J.J.2    Olopade, O.I.3
  • 93
    • 77956575301 scopus 로고    scopus 로고
    • Racial disparities in stage-specific colorectal cancer mortality: 1960-2005
    • Soneji S, Iyer SS, Armstrong K, Asch DA. Racial disparities in stage-specific colorectal cancer mortality: 1960-2005. Am. J. Public Health 100(10), 1912-1916 (2010).
    • (2010) Am. J. Public Health , vol.100 , Issue.10 , pp. 1912-1916
    • Soneji, S.1    Iyer, S.S.2    Armstrong, K.3    Asch, D.A.4
  • 94
    • 54049152885 scopus 로고    scopus 로고
    • Effects of socioeconomic status and treatment disparities in colorectal cancer survival
    • Le H, Ziogas A, Lipkin SM, Zell JA. Effects of socioeconomic status and treatment disparities in colorectal cancer survival. Cancer Epidemiol. Biomarkers Prev. 17(8), 1950-1962 (2008).
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , Issue.8 , pp. 1950-1962
    • Le, H.1    Ziogas, A.2    Lipkin, S.M.3    Zell, J.A.4
  • 95
    • 22544487188 scopus 로고    scopus 로고
    • Differences in colorectal carcinoma stage and survival by race and ethnicity
    • Chien C, Morimoto LM, Tom J, Li CI. Differences in colorectal carcinoma stage and survival by race and ethnicity. Cancer 104(3), 629-639 (2005).
    • (2005) Cancer , vol.104 , Issue.3 , pp. 629-639
    • Chien, C.1    Morimoto, L.M.2    Tom, J.3    Li, C.I.4
  • 96
    • 77951639959 scopus 로고    scopus 로고
    • Race and colorectal cancer disparities: Health-care utilization vs different cancer susceptibilities
    • Laiyemo AO, Doubeni C, Pinsky PF et al. Race and colorectal cancer disparities: health-care utilization vs different cancer susceptibilities. J. Natl Cancer Inst. 102(8), 538-546 (2010).
    • (2010) J. Natl Cancer Inst. , vol.102 , Issue.8 , pp. 538-546
    • Laiyemo, A.O.1    Doubeni, C.2    Pinsky, P.F.3
  • 97
    • 0035049008 scopus 로고    scopus 로고
    • Racial differences in colorectal cancer mortality. The importance of stage and socioeconomic status
    • Marcella S, Miller JE. Racial differences in colorectal cancer mortality. The importance of stage and socioeconomic status. J. Clin. Epidemiol. 54(4), 359-366 (2001).
    • (2001) J. Clin. Epidemiol. , vol.54 , Issue.4 , pp. 359-366
    • Marcella, S.1    Miller, J.E.2
  • 98
    • 0028856382 scopus 로고
    • Determinants of black/white differences in colon cancer survival
    • Mayberry RM, Coates RJ, Hill HA et al. Determinants of black/white differences in colon cancer survival. J. Natl Cancer Inst. 87(22), 1686-1693 (1995).
    • (1995) J. Natl Cancer Inst. , vol.87 , Issue.22 , pp. 1686-1693
    • Mayberry, R.M.1    Coates, R.J.2    Hill, H.A.3
  • 99
    • 77957567369 scopus 로고    scopus 로고
    • Racial disparities in colorectal cancer survival: To what extent are racial disparities explained by differences in treatment, tumor characteristics, or hospital characteristics?
    • White A, Vernon SW, Franzini L, Du XL. Racial disparities in colorectal cancer survival: to what extent are racial disparities explained by differences in treatment, tumor characteristics, or hospital characteristics? Cancer 116(19), 4622-4631 (2010).
    • (2010) Cancer , vol.116 , Issue.19 , pp. 4622-4631
    • White, A.1    Vernon, S.W.2    Franzini, L.3    Du, X.L.4
  • 100
    • 17344366045 scopus 로고    scopus 로고
    • Aggressiveness of colon carcinoma in blacks and whites. National Cancer Institute black/white cancer survival study group
    • Chen VW, Fenoglio-Preiser CM, Wu XC et al. Aggressiveness of colon carcinoma in blacks and whites. National Cancer Institute black/white cancer survival study group. Cancer Epidemiol. Biomarkers Prev. 6(12), 1087-1093 (1997).
    • (1997) Cancer Epidemiol. Biomarkers Prev. , vol.6 , Issue.12 , pp. 1087-1093
    • Chen, V.W.1    Fenoglio-Preiser, C.M.2    Wu, X.C.3
  • 101
    • 84860224916 scopus 로고    scopus 로고
    • Occult tumor burden contributes to racial disparities in stage-specific colorectal cancer outcomes
    • Hyslop T, Weinberg DS, Schulz S, Barkun A, Waldman SA. Occult tumor burden contributes to racial disparities in stage-specific colorectal cancer outcomes. Cancer 118(9), 2532-2540 (2011).
    • (2011) Cancer , vol.118 , Issue.9 , pp. 2532-2540
    • Hyslop, T.1    Weinberg, D.S.2    Schulz, S.3    Barkun, A.4    Waldman, S.A.5
  • 102
    • 0029896286 scopus 로고    scopus 로고
    • Looking forward in diagnostic pathology: The molecular superhighway
    • Abati A, Liotta LA. Looking forward in diagnostic pathology: the molecular superhighway. Cancer 78(1), 1-3 (1996).
    • (1996) Cancer , vol.78 , Issue.1 , pp. 1-3
    • Abati, A.1    Liotta, L.A.2
  • 103
    • 53849137996 scopus 로고    scopus 로고
    • Accelerating drug development using biomarkers: A case study with sitagliptin, a novel DPP4 inhibitor for Type 2 diabetes
    • Krishna R, Herman G, Wagner JA. Accelerating drug development using biomarkers: a case study with sitagliptin, a novel DPP4 inhibitor for Type 2 diabetes. AAPS J. 10(2), 401-409 (2008).
    • (2008) AAPS J. , vol.10 , Issue.2 , pp. 401-409
    • Krishna, R.1    Herman, G.2    Wagner, J.A.3
  • 104
    • 32544451155 scopus 로고    scopus 로고
    • Fit-for-purpose method development and validation for successful biomarker measurement
    • Lee JW, Devanarayan V, Barrett YC et al. Fit-for-purpose method development and validation for successful biomarker measurement. Pharm. Res. 23(2), 312-328 (2006).
    • (2006) Pharm. Res. , vol.23 , Issue.2 , pp. 312-328
    • Lee, J.W.1    Devanarayan, V.2    Barrett, Y.C.3
  • 105
    • 20944433395 scopus 로고    scopus 로고
    • Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: A conference report
    • Lee JW, Weiner RS, Sailstad JM et al. Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report. Pharm. Res. 22(4), 499-511 (2005).
    • (2005) Pharm. Res. , vol.22 , Issue.4 , pp. 499-511
    • Lee, J.W.1    Weiner, R.S.2    Sailstad, J.M.3
  • 106
    • 0036399255 scopus 로고    scopus 로고
    • Overview of biomarkers and surrogate endpoints in drug development
    • Wagner JA. Overview of biomarkers and surrogate endpoints in drug development. Dis. Markers 18(2), 41-46 (2002).
    • (2002) Dis. Markers , vol.18 , Issue.2 , pp. 41-46
    • Wagner, J.A.1
  • 107
    • 38349141917 scopus 로고    scopus 로고
    • Back to the future: Driving innovation in drug development
    • Wagner JA. Back to the future: driving innovation in drug development. Clin. Pharmacol. Ther. 83(2), 199-202 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.83 , Issue.2 , pp. 199-202
    • Wagner, J.A.1
  • 108
    • 41149108215 scopus 로고    scopus 로고
    • Strategic approach to fit-for-purpose biomarkers in drug development
    • Wagner JA. Strategic approach to fit-for-purpose biomarkers in drug development. Annu. Rev. Pharmacol. Toxicol. 48, 631-651 (2008).
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 631-651
    • Wagner, J.A.1
  • 109
    • 33845974419 scopus 로고    scopus 로고
    • Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugs
    • Wagner JA, Williams SA, Webster CJ. Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugs. Clin. Pharmacol. Ther. 81(1), 104-107 (2007).
    • (2007) Clin. Pharmacol. Ther. , vol.81 , Issue.1 , pp. 104-107
    • Wagner, J.A.1    Williams, S.A.2    Webster, C.J.3
  • 110
    • 33750515034 scopus 로고    scopus 로고
    • A cost-effectiveness approach to the qualification and acceptance of biomarkers
    • Williams SA, Slavin DE, Wagner JA, Webster CJ. A cost-effectiveness approach to the qualification and acceptance of biomarkers. Nat. Rev. Drug Discov. 5(11), 897-902 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.11 , pp. 897-902
    • Williams, S.A.1    Slavin, D.E.2    Wagner, J.A.3    Webster, C.J.4
  • 111
    • 0036327632 scopus 로고    scopus 로고
    • Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach
    • Park J, Schulz S, Haaf J, Kairys JC, Waldman SA. Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach. Cancer Epidemiol. Biomarkers Prev. 11(8), 739-744 (2002).
    • (2002) Cancer Epidemiol. Biomarkers Prev. , vol.11 , Issue.8 , pp. 739-744
    • Park, J.1    Schulz, S.2    Haaf, J.3    Kairys, J.C.4    Waldman, S.A.5
  • 112
    • 22244441099 scopus 로고    scopus 로고
    • Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma
    • Croner RS, Peters A, Brueckl WM et al. Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma. Cancer 104(2), 395-404 (2005).
    • (2005) Cancer , vol.104 , Issue.2 , pp. 395-404
    • Croner, R.S.1    Peters, A.2    Brueckl, W.M.3
  • 113
    • 33646369393 scopus 로고    scopus 로고
    • Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band
    • Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA, Clark SJ. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat. Genet. 38(5), 540-549 (2006).
    • (2006) Nat. Genet. , vol.38 , Issue.5 , pp. 540-549
    • Frigola, J.1    Song, J.2    Stirzaker, C.3    Hinshelwood, R.A.4    Peinado, M.A.5    Clark, S.J.6
  • 114
    • 0028321495 scopus 로고
    • Allelic loss of chromosome 18q and prognosis in colorectal cancer
    • Jen J, Kim H, Piantadosi S et al. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N. Engl. J. Med. 331(4), 213-221 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , Issue.4 , pp. 213-221
    • Jen, J.1    Kim, H.2    Piantadosi, S.3
  • 115
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351(27), 2817-2826 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , Issue.27 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 116
    • 2442684455 scopus 로고    scopus 로고
    • Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer
    • Wang Y, Jatkoe T, Zhang Y et al. Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J. Clin. Oncol. 22(9), 1564-1571 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , Issue.9 , pp. 1564-1571
    • Wang, Y.1    Jatkoe, T.2    Zhang, Y.3
  • 117
    • 80053238941 scopus 로고    scopus 로고
    • Delivering affordable cancer care in high-income countries
    • Sullivan R, Peppercorn J, Sikora K et al. Delivering affordable cancer care in high-income countries. Lancet Oncol. 12(10), 933-980 (2011).
    • (2011) Lancet Oncol. , vol.12 , Issue.10 , pp. 933-980
    • Sullivan, R.1    Peppercorn, J.2    Sikora, K.3
  • 118
    • 77957995461 scopus 로고    scopus 로고
    • Cost effectiveness of pharmacogenomics: A critical and systematic review
    • Wong WB, Carlson JJ, Thariani R, Veenstra DL. Cost effectiveness of pharmacogenomics: a critical and systematic review. Pharmacoeconomics 28(11), 1001-1013.
    • Pharmacoeconomics , vol.28 , Issue.11 , pp. 1001-1013
    • Wong, W.B.1    Carlson, J.J.2    Thariani, R.3    Veenstra, D.L.4
  • 119
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Allegra CJ, Jessup JM, Somerfield MR et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 27(12), 2091-2096 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.12 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3
  • 120
    • 77956989641 scopus 로고    scopus 로고
    • Cancer biomarkers: Where medicine, business, and public policy intersect
    • Wilson C, Schulz S, Waldman S. Cancer biomarkers: where medicine, business, and public policy intersect. Biotechnology Healthcare February, 33-42 (2007).
    • (2007) Biotechnology Healthcare February , pp. 33-42
    • Wilson, C.1    Schulz, S.2    Waldman, S.3
  • 121
    • 34247247181 scopus 로고    scopus 로고
    • Biomarker development, commercialization, and regulation: Individualization of medicine lost in translation
    • Wilson C, Schulz S, Waldman SA. Biomarker development, commercialization, and regulation: individualization of medicine lost in translation. Clin. Pharmacol. Ther. 81(2), 153-155 (2007).
    • (2007) Clin. Pharmacol. Ther. , vol.81 , Issue.2 , pp. 153-155
    • Wilson, C.1    Schulz, S.2    Waldman, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.