Design and in vitro and in vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: A technical note

AAPS PharmSciTech

Volumn 4, Issue 3, 2003, Pages

  Chowdary, K P R ^a   Rao, Y Srinivasa ^a  

^a ANDHRA UNIVERSITY   (India)

Author keywords

Controlled release; Glipizide; Mucoadhesive microcapsules

Indexed keywords

ALGINIC ACID; CARBOMER; GLIPIZIDE; GLUCOSE; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; POLYMER; ACRYLIC ACID DERIVATIVE; CARBOXYMETHYLCELLULOSE; GLUCURONIC ACID; HEXURONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG ADSORPTION; DRUG DESIGN; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; GASTROINTESTINAL ABSORPTION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MICROCAPSULE; MICROENCAPSULATION; NONHUMAN; ADHESION; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG FORMULATION; DRUG SCREENING; METABOLISM; METHODOLOGY; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; RABBIT;

ACRYLATES; ADHESIVENESS; ADMINISTRATION, ORAL; ALGINATES; ANIMALS; CAPSULES; CARBOXYMETHYLCELLULOSE; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GLIPIZIDE; GLUCURONIC ACID; HEXURONIC ACIDS; METHYLCELLULOSE; RABBITS; TECHNOLOGY, PHARMACEUTICAL;

EID: 23144449562     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt040339     Document Type: Article

References (19)

1. Kondo A, ed. Micro-capsule Processing and Technology. New York, NY: Marcel Dekker; 1979:18.
2. Gutcho MH, ed. Microcapsules and Microencapsulation Techniques. Park Ridge NJ: Noyes Data Corporation; 1976:236.
3. Ikeda K, Murata K, Kobayashi M, Noda K. Enhancement of bioavailability of dopamine via nasal route in beagle dogs. Chem Pharm Bull. 1992;40(8):2155-2158.
4. Nagai T, Nishimoto Y, Nambu N, Suzuki Y, Sekine K. Powder dosage forms of insulin for nasal administration. J Control Release. 1984;1:15-22.
5. Illum L, Farraj NF, Critcheley H, Davis SS. Nasal administration of gentamicin using a novel microsphere delivery system. Int J Pharm. 1988;46:261-265.
6. Gavini E, Sanna V, Juliano C, Bonferoni MS, Giunchedi P. Mucoadhesive vaginal tablets as veterinary delivery system for the controlled release of an antimicrobial drug, acriflavine. AAPS PharmSci Tech. 2002;3: article 20.
7. Chowdary KPR, Srinivas L. Mucoadhesive drug delivery systems: a status of current review. Indian Drugs. 2000;37:400-406.
8. Sakagami M, Kinoshita W, Sakon K, Sato JI, Makino Y. Mucoadhesive beclomethasone microspheres for powder inhalation: their pharmacokinetics and pharmacodynamics evaluation. J Control Release. 2002;80:207-218.
9. Takishima J, Onishi H, Machida Y. Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats. Biol Pharm Bull. 2002;25:1498-1502.
10. Lim ST, Forbes B, Berry DJ, Martin GP, Brown MB. In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits. Int J Pharm. 2002;231:73-82.
11. Cuna M, Alonso MJ, Torres D. Preparation and in vivo evaluation of mucoadhesive microparticles containing amoxicillin-resin complexes for drug delivery to the gastric mucosa. Eur J Pharm Biopharm. 2001;51:199-205.
12. Kahn CR, Shechter Y. Oral hypoglycemic agents and the pharmacology of the endocrine pancreas. In: Theodore WR, Alan SN, Taylor P, Gilman AG, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY: McGraw-Hill; 1991:1484.
13. Kim CK, Lee EJ. The controlled release of blue dextran from alginate beads. Int J Pharm. 1992;79:11-19.
14. Hari PC, Chandy T, Sharma CP. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. J Microencapsul. 1996;13:319-329.
15. The United States Pharmacopeia, XXIII. Rockville, MD: United States Pharmacopeial Convention, Inc; 1995:801.
16. Lehr CM, Bowstra JA, Tukker JJ, Junginer HE. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat. J Control Release. 1990;13:51-62.
17. Trinder P. Glucose oxidase-peroxidase method. Ann Clin Biochem. 1964;6:24.
18. Ch'ng HS, Park H, Kelly P, Robinson JR. For oral controlled delivery, II: synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J Pharm Sci. 1985;74:399-405.
19. Kahn CR, Shechter Y. In: Theodore WR, Alan SN, Taylor P, Gilman AG, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY: McGraw-Hill; 1991:1712.