Immunomodulatory and physical effects of phospholipid composition in vaccine adjuvant emulsions

AAPS PharmSciTech

Volumn 13, Issue 2, 2012, Pages 498-506

  Fox, Christopher B ^a   Baldwin, Susan L ^a   Duthie, Malcolm S ^a,b   Reed, Steven G ^a,c   Vedvick, Thomas S ^a  

^a INFECTIOUS DISEASE RESEARCH INSTITUTE   (United States)

^b Protein Advances Inc   (United States)

^c Immune Design Corp   (United States)

Author keywords

oil in water emulsion; phosphatidylcholine; squalene; vaccine adjuvant

Indexed keywords

1,2 DILAUROYL SN GLYCERO 3 PHOSPHOCHOLINE; ADJUVANT; EMULSIFYING AGENT; INFLUENZA VACCINE; MALARIA VACCINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; RECOMBINANT ANTIGEN; SQUALENE 1 PALMITOYL 2 OLEOYL SN GLYCERO 3 PHOSPHOCHOLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; EGG; EMULSION; FEMALE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOMODULATION; LIPID COMPOSITION; MALARIA; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; STORAGE TEMPERATURE; VISCOSITY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES; CHEMISTRY, PHARMACEUTICAL; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DRUG STABILITY; EMULSIFYING AGENTS; EMULSIONS; FEMALE; HUMANS; IMMUNIZATION; INFLUENZA VACCINES; INJECTIONS, INTRAMUSCULAR; MALARIA VACCINES; MICE; MICE, INBRED BALB C; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; SQUALENE; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 84862889354     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9771-x     Document Type: Article

References (32)

1. CB Fox 2009 Squalene emulsions for parenteral vaccine and drug delivery Molecules 14 3286 3312 19783926 10.3390/molecules14093286 1:CAS:528: DC%2BD1MXhtVyltrjN
2. LH Reddy P Couvreur 2009 Squalene: a natural triterpene for use in disease management and therapy Adv Drug Del Rev 61 1412 1426 10.1016/j.addr.2009.09.005 1:CAS:528:DC%2BD1MXhsVWlsrrM
3. LA Brito M Chan B Baudner S Gallorini G Santos DT O'Hagan, et al. 2011 An alternative renewable source of squalene for use in emulsion adjuvants Vaccine 29 6262 6268 21723355 10.1016/j.vaccine.2011.06.067 1:CAS:528:DC%2BC3MXhtValtLjL
4. YW Yang CA Wu WJW Morrow 2004 Cell death induced by vaccine adjuvants containing surfactants Vaccine 22 1524 1536 15063578 10.1016/j.vaccine.2003.08. 048 1:CAS:528:DC%2BD2cXivVCqu7w%3D (Pubitemid 38446931)
5. ML Forchielli G Bersani S Tala G Grossi C Puggioli M Masi 2010 The spectrum of plant and animal sterols in different oil-derived intravenous emulsions Lipids 45 63 71 20049583 10.1007/s11745-009-3371-x 1:CAS:528:DC%2BC3cXis1anug%3D%3D
6. EAAM Vernooij JJ Kettens-van den Bosch DJA Crommelin 1998 Rapid determination of acyl chain position in egg phosphatidylcholine by high-performance liquid chromatography/electrospray mass spectrometry Rapid Comm Mass Spec 12 83 86 10.1002/(SICI)1097-0231(19980131)12:2<83::AID- RCM120>3.0.CO;2-M 1:CAS:528:DyaK1cXnsVOqtA%3D%3D (Pubitemid 28050424)
7. de Man JM. Chemical and physical properties of fatty acids. In: Chow CK, editor. Fatty acids in foods and their health implications. Boca Raton: CRC Press; 2008. p. 17-46.
8. CB Fox SL Baldwin MS Duthie SG Reed TS Vedvick 2011 Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions Vaccine 29 9563 9572 21906648 10.1016/j.vaccine.2011.08.089 1:CAS:528:DC%2BC3MXhsFGjtrfM
9. CB Fox S Lin SJ Sivananthan TS Dutill KT Forseth SG Reed, et al. 2011 Effects of emulsifier concentration, composition, and order of addition in squalene-phosphatidylcholine oil-in-water emulsions Pharm Dev Technol 16 511 519 20550484 10.3109/10837450.2010.495397 1:CAS:528:DC%2BC3MXhtFOmtr%2FN
10. MR Hilleman 1999 Personal historical chronicle of six decades of basic and applied research in virology, immunology, and vaccinology Immunol Rev 170 7 27 10566138 10.1111/j.1600-065X.1999.tb01325.x 1:STN:280: DC%2BD3c%2Fjt1GksA%3D%3D (Pubitemid 29490741)
11. SA Rosenberg JC Yang US Kammula MS Hughes NP Restifo SL Schwarz, et al. 2010 Different adjuvanticity of incomplete Freund's adjuvant derived from beef or vegetable components in melanoma patients immunized with a peptide vaccine J Immunother 33 626 629 20551834 10.1097/CJI.0b013e3181dac9de 1:CAS:528: DC%2BC3cXnvFymu78%3D
12. TK Bock BW Muller 1994 A novel assay to determine the hemolytic activity of drugs incorporated in colloidal carrier systems Pharm Res 11 589 591 8058621 10.1023/A:1018987120738 1:CAS:528:DyaK2cXivVSisLw%3D (Pubitemid 24144456)
13. SL Baldwin N Shaverdian Y Goto MS Duthie VS Raman T Evers, et al. 2009 Enhanced humoral and Type 1 cellular immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsion Vaccine 27 5956 5963 19679214 10.1016/j.vaccine.2009.07.081 1:CAS:528:DC%2BD1MXhtFyjs7rP
14. Amselem S, Zawoznik E, Yogev A, Friedman D. Emulsomes, a new type of lipid assembly. In: Barenholz Y, Lasic DD, editors. Handbook of Nonmedical Applications of Liposomes: From design to microreactors. New York: CRC Press. 1995;209-23.
15. EAAM Vernooij JFHM Brouwers JJ Kettenes-van den Bosch DJA Crommelin 2002 RP-HPLC/ESI MS determination of acyl chain positions in phospholipids J Sep Sci 25 285 289 10.1002/1615-9314(20020401)25:5/6<285::AID-JSSC285>3.0.CO;2-U 1:CAS:528:DC%2BD38XjtlWmtrk%3D (Pubitemid 34467060)
16. CB Fox RH Uibel JM Harris 2007 Detecting phase transitions in phosphatidylcholine vesicles by Raman microscopy and self-modeling curve resolution J Phys Chem B 111 39 11428 11436 17850068 10.1021/jp0735886 1:CAS:528:DC%2BD2sXhtVWrsLfP (Pubitemid 47598324)
17. AR Falsey 2008 Half-dose influenza vaccine Arch Intern Med 168 2402 2403 19064820 10.1001/archinte.168.22.2402
18. T Yasuda GF Dancey SC Kinsky 1977 Immunogenicity of liposomal model membranes in mice: dependence on phospholipid composition Proc Natl Acad Sci 74 1234 1236 265565 10.1073/pnas.74.3.1234 1:CAS:528:DyaE2sXhsFersb4%3D (Pubitemid 8065640)
19. BC Baudner V Ronconi D Casini M Tortoli J Kazzaz M Singh, et al. 2009 MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020) Pharm Res 26 1477 1485 19255727 10.1007/s11095-009-9859-5 1:CAS:528:DC%2BD1MXisFWns7g%3D
20. Mikrut B. Case study: formulation of an intravenous fat emulsion. In: Burgess DJ, editor. Injectable dispersed systems: formulation, processing, and performance. Boca Raton: Taylor and Francis; 2005. p. 415-25.
21. JK Yoon DJ Burgess 1996 Interfacial properties as stability predictors of lecithin-stabilized perfluorocarbon emulsions Pharm Dev Tech 1 333 341 10.3109/10837459609031428 1:CAS:528:DyaK2sXhsVShsw%3D%3D (Pubitemid 28257336)
22. A Kabalnov T Tarara R Arlauskas J Weers 1996 Phospholipids as emulsion stabilizers: phase behavior versus emulsion stability J Coll Inter Sci 184 227 235 1:CAS:528:DyaK28XntFOhtLo%3D (Pubitemid 26413182)
23. Mollet H, Grubenmann A. Formulation technology: emulsions, suspensions, solid forms. New York: Wiley; 2001.
24. T Nii F Ishii 2004 Properties of various phosphatidylcholines as emulsifiers or dispersing agents in microparticle preparations for drug carriers Colloids Surf B: Biointerfaces 39 1-2 57 63 10.1016/j.colsurfb.2004.08.017 1:CAS:528:DC%2BD2cXpslOqsbk%3D (Pubitemid 39473354)
25. CB Fox RC Anderson TS Dutill Y Goto SG Reed T Vedvick 2008 Monitoring the effects of component structure and source and formulation stability and adjuvant activity of oil-in-water emulsions Colloids Surf B: Biointerfaces 65 98 105 10.1016/j.colsurfb.2008.03.003 1:CAS:528:DC%2BD1cXntlSnt7s%3D
26. J Bibette DC Morse TA Witten DA Weitz 1992 Stability criteria for emulsions Phys Rev Lett 69 16 2439 10046485 10.1103/PhysRevLett.69.2439 1:CAS:528:DyaK3sXht1Snsw%3D%3D
27. I Capek 2004 Degradation of kinetically-stable o/w emulsions Adv Coll Inter Sci 107 2-3 125 155 10.1016/S0001-8686(03)00115-5 1:CAS:528: DC%2BD2cXitVKhtb4%3D
28. DG Dalgleish 1997 Adsorption of protein and the stability of emulsions Trends Food Sci Technol 8 1 1 6 10.1016/S0924-2244(97)01001-7 1:CAS:528:DyaK2sXhtFaiu70%3D (Pubitemid 27100932)
29. DJ McClements 2007 Critical review of techniques and methodologies for characterization of emulsion stability Crit Rev Food Sci Nutr 47 611 649 17943495 10.1080/10408390701289292 1:CAS:528:DC%2BD2sXhtFOju7vE (Pubitemid 47613322)
30. SA Tatulian 1987 Binding of alkaline-earth metal cations and some anions to phosphatidylcholine liposomes Eur J Biochem 170 413 420 3691530 10.1111/j.1432-1033.1987.tb13715.x 1:CAS:528:DyaL1cXisVWh
31. SA Tatulian 1983 Effect of lipid phase transition on the binding of anions to dimyristoylphosphatidylcholine liposomes Biochim Biophys Acta 736 189 195 6652082 10.1016/0005-2736(83)90283-3 1:STN:280:DyaL2c%2FotVCntw%3D%3D
32. Y Tanaka K Mashino K Inoue S Nojima 1983 Mechanism of human erythrocyte hemolysis induced by short-chain phosphatidylcholines and lysophosphatidylcholine J Biochem 94 833 840 6643425 1:CAS:528: DyaL2cXitV2nug%3D%3D (Pubitemid 13017422)