Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles

Heart Rhythm

Volumn 9, Issue 7, 2012, Pages 1125-1132

  Lee, Young Soo ^a   Maruyama, Mitsunori ^a   Chang, Po Cheng ^a   Park, Hyung Wook ^a   Rhee, Kyoung Suk ^a   Hsieh, Yu Cheng ^a   Hsueh, Chia Hsiang ^a   Shen, Changyu ^b   Lin, Shien Fong ^a   Hwang, Hyun Seok ^c   Yin, Huiyong ^c   Knollmann, Björn C ^c   Chen, Peng Sheng ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Action potentials; Antiarrhythmic agents; Calcium; Depolarization

Indexed keywords

CALCIUM; ISOPRENALINE; LIDOCAINE; PROPAFENONE; RYANODINE RECEPTOR;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEPOLARIZATION; FEMALE; HUMAN; INHIBITION KINETICS; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; TACHYCARDIA; VELOCITY;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CARDIAC PACING, ARTIFICIAL; DRUG SYNERGISM; HEART VENTRICLES; LIDOCAINE; RABBITS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 84862887984     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2012.02.031     Document Type: Article

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