The effects of tetramethylpyrazine on learning and memory abilities of mice with Alzheimer disease and its possible mechanism

Chinese Pharmacological Bulletin

Volumn 24, Issue 8, 2008, Pages 1088-1092

  Zhao, Lin ^a   Wei, Min Jie ^a   He, Miao ^a   Jin, Wan Bao ^a   Zhao, Hai Shan ^a   Yao, Wei Fan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer disease; Chemical drugs induction; Mouse model; Tetramethylpyrazine

Indexed keywords

ACETYLCHOLINESTERASE; ALUMINUM CHLORIDE; ALUMINUM TRICHLORIDE; AMYLOID BETA PROTEIN; GALACTOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; SODIUM NITRITE; SUPEROXIDE DISMUTASE; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; COLORIMETRY; DRUG MECHANISM; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; LEARNING; MAZE TEST; MEMORY; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

EID: 56249102483     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Shen Y X, Yang J, Wei W, et al. Induction of learning and memory dysfunction by β-amyloid peptide fragment 25 - 35 in rats[J]. Chin Pharmacol Bull, 2001,17(1):26-9.
2. Sun Q. Oxidative damages and Alzheimer's diseases[J]. Foreign Med Sci • Geriatrics, 2002,23(5):226-30.
3. Shu B, Zhou C J, Ma Y H, et al. Research progress on pharmacological activities of the available compositions in Chinese medicinal herb Ligusticum chuanxiong[J]. Chin Pharmacol Bull, 2006,22 (9):1043-7.
4. Gao Y, Liang S D. Animal model of neuropathic pain and its application to research on pain mediated by P2X receptors[J]. Chin Pharmacol Bull, 2006,22(11):1310-4.
5. Li Y H, Li J, Lü X W, et al. Effects of interaction between propofol and ligustrazin on hepatic ischemia-reperfusion injury in rat[J]. Chin Pharmacol Bull, 2006,22(4):452-6.
6. Chen G, Xu X Y, Ye L, et al. Effects of tetramethylpyrazine on the expression of vascular endothelial growth factor in synovium of collagen-induced arthritis in rats[J]. Chin Pharmacol Bull, 2006,22 (10):1199-202.
7. Zhang C, Wang S Z, Zuo P P, et al. Effect of tetramethylpyrazine on learning, memory and cholinergic system in D-galactose-lesioned mice[J]. Acta Acad Med Sin,2003,25(5):553-6. 26-9.
8. Luo H M, Chen Z S. A novel animal model of Alzheimer disease [J]. Chin J Gerontol, 2003,3(23):179-82.
9. Harkany T, Lengyel Z, Kasa P, Gluya K. Chronic aluminum treatment result in aluminum deposits and affects M1 muscarinic receptors in rat brain[J]. Neurobiology,1996,4(1-2):35-43.
10. Chen Y X, Zhou R L, Cui J C. Effect of YZS on Scopolamine induced alzheimer disease model mice[J]. Chin J Exp Trad Med Formul, 2004,3(10):41-2.
11. Belles M, Sanchez D J, Gomez M, et al. Sillicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease[J]. Alzheimer Dis Assoc Disord,1998,12(2): 83-7.
12. El-Sebae A H, Abdel-Ghany M E, Shalloway D, et al. Aluminum interaction with human brain tau protein phosphorylation by various kinases[J]. J Environ Sci Health B,1993,28(6):763-77.
13. Shang Y Z, Gong M Y, Zhou X X. Improving effects of SSF on memory deficits and pathological changes of neural and immunological systems in senescent mice[J]. Acta Pharmacol Sin, 2001, 22:1078-83.
14. Li X, Zhang X F, Qiao C L. Effect of Nao er kang on learning and memory disorders in model rats with Alzheimer diseases[J]. China J Trad Chin Med Pharm, 2001,16(5):24-7.
15. Feng G, Kelly R, Richard C, et al. NF-κB mediates L-induced synthesis/release of α-macroglobulin in a human glial cell line [J]. Mol Brain Res, 2002,105(122):108-14.
16. Hang C H, Shi J X, Li J S, et al. Expression of intestinal NF-kappaB, TNF-alpha, and IL-6 following traumatic brain injury in rats [J]. J Surg Res, 2005,123(2):188-93.