FoxO3a changes in pyramidal neurons and expresses in non-pyramidal neurons and astrocytes in the gerbil hippocampal CA1 region after transient cerebral ischemia

Neurochemical Research

Volumn 37, Issue 3, 2012, Pages 588-595

  Yoo, Ki Yeon ^a   Kwon, Seung Hae ^b   Lee, Choong Hyun ^c   Yan, Bingchun ^d   Park, Joon Ha ^d   Ahn, Ji Hyeon ^e   Choi, Jung Hoon ^d   Ohk, Taek Geun ^f   Cho, Jun Hwi ^d   Won, Moo Ho ^d  

^a Gangneung Wonju National University   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Dankook University   (South Korea)

^d Kangwon National University   (South Korea)

^e Daegu University   (South Korea)

^f Hallym University   (South Korea)

Author keywords

Astrocytes; Delayed neuronal death; Forkhead box O proteins; Hippocampus; Ischemic damage; Pyramidal neurons

Indexed keywords

TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN LEVEL; CONTROLLED STUDY; GABAERGIC SYSTEM; GERBIL; HIPPOCAMPAL CA1 REGION; IMMUNOREACTIVITY; INTERNEURON; MALE; MERIONES UNGUICULATUS; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PYRAMIDAL NERVE CELL; REPERFUSION INJURY; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; BRAIN ISCHEMIA; FORKHEAD TRANSCRIPTION FACTORS; GERBILLINAE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; PYRAMIDAL CELLS;

GERBILLINAE;

EID: 84862866747     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0648-2     Document Type: Article

References (36)

1. Kirino T (1982) Delayed neuronal death in the gerbil hippo-campus following ischemia. Brain Res 239:57-69 (Pubitemid 12101768)
2. Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11:491-498 (Pubitemid 12158810)
3. Hara A, Niwa M, Iwai T et al (1998) Transport of fragmented DNA in apical dendrites of gerbil CA1 pyramidal neurons following transient forebrain ischemia. Brain Res 806:274-277 (Pubitemid 29010503)
4. Northington FJ, Ferriero DM, Graham EM et al (2001) Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis. Neurobiol Dis 8:207-219 (Pubitemid 32382476)
5. Ohmura A, Nakajima W, Ishida A et al (2005) Prolonged hypothermia protects neonatal rat brain against hypoxic-ischemia by reducing both apoptosis and necrosis. Brain Dev 27:517-526 (Pubitemid 41383493)
6. Chong ZZ, Lin SH, Maiese K (2004) The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential. J Cereb Blood Flow Metab 24:728-743 (Pubitemid 38880218)
7. Chong ZZ, Li F, Maiese K (2005) Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 75:207-246 (Pubitemid 40693131)
8. Zaheer A, Sahu SK, Ryken TC et al (2007) Cis-parinaric acid effects, cytotoxicity, c-Jun N-terminal protein kinase, forkhead transcription factor and Mn-SOD differentially in malignant and normal astrocytes. Neurochem Res 32:115-124 (Pubitemid 46020937)
9. Wang Y, Liu Y, Chen Y et al (2009) Peripheral nerve injury induces down-regulation of Foxo3a and p27kip1 in rat dorsal root ganglia. Neurochem Res 34:891-898
10. Clark KL, Halay ED, Lai E et al (1993) Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364:412-420 (Pubitemid 23263212)
11. Jin C, Marsden I, Chen X et al (1998) Sequence specific collective motions in a winged helix DNA binding domain detected by 15N relaxation NMR. Biochemistry 37:6179-6187 (Pubitemid 28196775)
12. Tran H, Brunet A, Griffith EC et al (2003) The many forks in FOXO's road. Sci STKE 2003:RE5
13. Hoekman MF, Jacobs FM, Smidt MP et al (2006) Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr Patterns 6:134-140 (Pubitemid 43071907)
14. Furuyama T, Nakazawa T, Nakano I et al (2000) Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J 349:629-634 (Pubitemid 30465799)
15. Biggs WH 3rd, Meisenhelder J, Hunter T et al (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96:7421-7426 (Pubitemid 29299677)
16. Brunet A, Bonni A, Ziqmond MJ et al (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868 (Pubitemid 29165088)
17. Rena G, Guo S, Cichy SC et al (1999) Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274:17179-17183
18. Tang ED, Nuñez G, Barr FG et al (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 274:16741-16746
19. Taub J, Lau JF, Ma C et al (1999) A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature 399:162-166
20. Kops GJ, Dansen TB, Polderman PE et al (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316-321
21. Schmidt M, Fernandez de Mattos S, van der Horst A et al (2002) Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol 22:7842-7852 (Pubitemid 35217295)
22. Gilley J, Coffer PJ, Ham J (2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162:613-622 (Pubitemid 37022939)
23. Won CK, Ji HH, Koh PO (2006) Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation. Neurosci Lett 398:39-43
24. Shioda N, Ishigami T, Han F et al (2007) Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia. Neuroscience 148:221-229 (Pubitemid 47211622)
25. Li D, Qu Y, Zhang X et al (2009) Involvement of the PTENAKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia. J Cereb Blood Flow Metab 29:1903-1913
26. Miyawaki T, Ofengeim D, Noh KM et al (2009) The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nat Neurosci 12:618-626
27. Jover-Mengual T, Miyawaki T, Latuszek A et al (2010) Acute estradiol protects CA1 neurons from ischemia-induced apoptotic cell death via the PI3K/Akt pathway. Brain Res 1321:1-12
28. Beresewicz M, Kowalczyk JE, Zablocka B (2008) Kalirin-7, a protein enriched in postsynaptic density, is involved in ischemic signal transduction. Neurochem Res 33:1789-1794
29. Schmued LC, Hopkins KJ (2000) Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874:123-130
30. Lee CH, Moon SM, Yoo KY et al (2010) Long-term changes in neuronal degeneration and microglial activation in the hippocampal CA1 region after experimental transient cerebral ischemic damage. Brain Res 1342:138-149
31. Chong ZZ, Li F, Maiese K (2005) Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury. Histol Histopathol 20:299-315 (Pubitemid 40029007)
32. Pirianov G, Brywe KG, Mallard C et al (2007) Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury. J Cereb Blood Flow Metab 27:1022-1032 (Pubitemid 46659033)
33. Chong ZZ, Li F, Maiese K (2006) Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress. Curr Neurovasc Res 3:107-117 (Pubitemid 43764787)
34. Sugawara T, Lewén A, Noshita N et al (2002) Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma 19:85-98 (Pubitemid 34126348)
35. Fukuda T, Nakano S, Yoshiya I et al (1993) Persistent degenerative state of non-pyramidal neurons in the CA1 region of the gerbil hippocampus following transient forebrain ischemia. Neuroscience 53:23-38 (Pubitemid 23083304)
36. Tortosa A, Ferrer I (1993) Parvalbumin immunoreactivity in the hippocampus of the gerbil after transient forebrain ischaemia: A qualitative and quantitative sequential study. Neuroscience 55: 33-43 (Pubitemid 23194983)