In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin

Journal of Pharmaceutical Sciences

Volumn 101, Issue 8, 2012, Pages 2854-2860

  Huttunen, Kristiina M ^a   Leppänen, Jukka ^a   Vepsäläinen, Jouko ^a   Sirviö, Jouni ^b   Laine, Krista ^a   Rautio, Jarkko ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b Oy Sauloner Ltd   (Finland)

Author keywords

Bioavailability; Caco 2 cells; In vitro in vivo correlations (IVIVC); Log P; Oral absorption; Permeability; Prodrugs

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CYSTEINE; GLUTATHIONE; LINEZOLID; MACROGOL STEARATE; METFORMIN; PRODRUG; SOLUTOL; SULFENAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG TOLERABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; WISTAR RAT;

EID: 84862862002     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23221     Document Type: Article

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