In vitro conversion of model sulfenamide prodrugs in the presence of small molecule thiols

Journal of Pharmaceutical Sciences

Volumn 100, Issue 3, 2011, Pages 1001-1008

  Nti Addae, Kwame W ^a,b   Stella, Valentino J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

Author keywords

Chemical stability; Drug like properties; Kinetics; Prodrugs; Stability

Indexed keywords

CYSTEINE; DISULFIDE; GLUTATHIONE; LINEZOLID; OXAZOLIDINONE DERIVATIVE; PHTHALIMIDE; PRODRUG; SULFENAMIDE DERIVATIVE; THIOL DERIVATIVE;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; STOICHIOMETRY;

EID: 78650516225     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22347     Document Type: Article

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