MDCK cell permeability characteristics of a sulfenamide prodrug: Strategic implications in considering sulfenamide prodrugs for oral delivery of NH-acids

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 172-175

  Guarino, Victor R ^a,b   Nti Addae, Kwame ^a,c   Stella, Valentino J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

NH acid; Oral delivery; Prodrug Strategy; Sulfenamide prodrug; Supersaturation

Indexed keywords

LINEZOLID; PRODRUG; SULFENAMIDE DERIVATIVE;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN; DRUG DELIVERY SYSTEM; DRUG METABOLISM; INTESTINE CELL; INTRACELLULAR TRANSPORT; NONHUMAN;

ACIDS; ADMINISTRATION, ORAL; ANIMALS; CELL LINE; CELL MEMBRANE PERMEABILITY; DOGS; PRODRUGS; SULFAMERAZINE;

EID: 78650514132     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.043     Document Type: Article

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