메뉴 건너뛰기




Volumn 95, Issue 4, 2012, Pages 371-379

Ex vivo expansion of umbilical cord blood: Where are we?

Author keywords

Expansion; Mechanisms; Stem cells; Umbilical cord blood

Indexed keywords

ALPHA4 INTEGRIN; ANGIOPOIETIN; CD34 ANTIGEN; CHAPERONE; CYTOKINE; GLUCOSE REGULATED PROTEIN 94; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; HOX PROTEIN; INTERLEUKIN 3; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; STAT PROTEIN; TELOMERASE; WNT PROTEIN;

EID: 84862860984     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-012-1053-6     Document Type: Review
Times cited : (10)

References (80)
  • 1
    • 0024396816 scopus 로고
    • Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling
    • Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med. 1989;321(17):1174-8.
    • (1989) N Engl J Med , vol.321 , Issue.17 , pp. 1174-1178
    • Gluckman, E.1    Broxmeyer, H.A.2    Auerbach, A.D.3
  • 2
    • 77953044213 scopus 로고    scopus 로고
    • New approaches for improving engraftment after cord blood transplantation
    • Rocha V, Broxmeyer HE. New approaches for improving engraftment after cord blood transplantation. Biol Blood Marrow Transplant. 2010;16(1 SUPPL.):S126-32.
    • (2010) Biol Blood Marrow Transplant , vol.16 , Issue.SUPPL.
    • Rocha, V.1    Broxmeyer, H.E.2
  • 3
    • 77952424786 scopus 로고    scopus 로고
    • Monitoring the international use of unrelated donors for transplantation: The WMDA annual reports
    • Foeken LM, Green A, Hurley CK, Marry E, Wiegand T, Oudshoorn M. Monitoring the international use of unrelated donors for transplantation: the WMDA annual reports. Bone Marrow Transplant. 2010;45(5):811-8.
    • (2010) Bone Marrow Transplant , vol.45 , Issue.5 , pp. 811-818
    • Foeken, L.M.1    Green, A.2    Hurley, C.K.3    Marry, E.4    Wiegand, T.5    Oudshoorn, M.6
  • 4
    • 77949619008 scopus 로고    scopus 로고
    • Both interleukin-3 and interleukin-6 are necessary for better ex vivo expansion of CD133? cells from umbilical cord blood
    • Bordeaux-Rego P, Luzo A, Costa FF, Olalla Saad ST, Crosara-Alberto DP. Both interleukin-3 and interleukin-6 are necessary for better ex vivo expansion of CD133? cells from umbilical cord blood. Stem Cells Dev. 2010;19(3):413-22.
    • (2010) Stem Cells Dev , vol.19 , Issue.3 , pp. 413-422
    • Bordeaux-Rego, P.1    Luzo, A.2    Costa, F.F.3    Olalla Saad, S.T.4    Crosara-Alberto, D.P.5
  • 5
    • 2942620004 scopus 로고    scopus 로고
    • Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication
    • Gammaitoni L, Weisel KC, Gunetti M, et al. Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication. Blood. 2004;103(12): 4440-8.
    • (2004) Blood , vol.103 , Issue.12 , pp. 4440-4448
    • Gammaitoni, L.1    Weisel, K.C.2    Gunetti, M.3
  • 6
    • 75149155592 scopus 로고    scopus 로고
    • History of cord blood transplantation
    • Gluckman E. History of cord blood transplantation. Bone Marrow Transplant. 2009;44(10):621-6.
    • (2009) Bone Marrow Transplant , vol.44 , Issue.10 , pp. 621-626
    • Gluckman, E.1
  • 7
    • 0035141378 scopus 로고    scopus 로고
    • Umbilical cord blood for allogeneic transplantation in children and adults
    • Laughlin MJ. Umbilical cord blood for allogeneic transplantation in children and adults. Bone Marrow Transplant. 2001;27(1):1-6.
    • (2001) Bone Marrow Transplant , vol.27 , Issue.1 , pp. 1-6
    • Laughlin, M.J.1
  • 8
    • 49749086464 scopus 로고    scopus 로고
    • Efforts of the United States' National Marrow Donor Program and Registry to improve utilization and representation of minority donors
    • Johansen KA, Schneider JF, Mccaffree MA, Woods GL. Efforts of the United States' National Marrow Donor Program and Registry to improve utilization and representation of minority donors. Transfus Med. 2008;18(4):250-9.
    • (2008) Transfus Med , vol.18 , Issue.4 , pp. 250-259
    • Johansen, K.A.1    Schneider, J.F.2    McCaffree, M.A.3    Woods, G.L.4
  • 9
    • 77957752908 scopus 로고    scopus 로고
    • Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities
    • Barker JN, Byam CE, Kernan NA, et al. Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities. Biol Blood Marrow Transplant. 2010;16(11):1541-8.
    • (2010) Biol Blood Marrow Transplant , vol.16 , Issue.11 , pp. 1541-1548
    • Barker, J.N.1    Byam, C.E.2    Kernan, N.A.3
  • 10
    • 0034667625 scopus 로고    scopus 로고
    • Cell dose and speed of engraftment in placental/ umbilical cord blood transplantation: Graft progenitor cell content is a better predictor than nucleated cell quantity
    • Migliaccio AR, Adamson JW, Stevens CE, Dobrila NL, Carrier CM, Rubinstein P. Cell dose and speed of engraftment in placental/ umbilical cord blood transplantation: graft progenitor cell content is a better predictor than nucleated cell quantity. Blood. 2000;96(8):2717-22.
    • (2000) Blood , vol.96 , Issue.8 , pp. 2717-2722
    • Migliaccio, A.R.1    Adamson, J.W.2    Stevens, C.E.3    Dobrila, N.L.4    Carrier, C.M.5    Rubinstein, P.6
  • 11
    • 58149165364 scopus 로고    scopus 로고
    • Results of the Cord Blood Transplantation Study (COBLT): Clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies
    • Kurtzberg J, Prasad VK, Carter SL, et al. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008;112(10): 4318-27.
    • (2008) Blood , vol.112 , Issue.10 , pp. 4318-4327
    • Kurtzberg, J.1    Prasad, V.K.2    Carter, S.L.3
  • 12
    • 79956052439 scopus 로고    scopus 로고
    • Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning
    • Kanda J, Rizzieri DA, Gasparetto C et al. Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning. Biol Blood Marrow Transplant. 2010;17(6):867-74.
    • (2010) Biol Blood Marrow Transplant , vol.17 , Issue.6 , pp. 867-874
    • Kanda, J.1    Rizzieri, D.A.2    Et Al., G.C.3
  • 13
    • 34047183776 scopus 로고    scopus 로고
    • Immune reconstitution after unrelated cord blood transplantation
    • Szabolcs P, Niedzwiecki D. Immune reconstitution after unrelated cord blood transplantation. Cytotherapy. 2007;9(2):111-22.
    • (2007) Cytotherapy , vol.9 , Issue.2 , pp. 111-122
    • Szabolcs, P.1    Niedzwiecki, D.2
  • 14
    • 15544364942 scopus 로고    scopus 로고
    • A modified cord blood collection method achieves sufficient cell levels for transplantation in most adult patients
    • Bornstein R, Flores AI, Montalban MA, Del Rey MJ, De La Serna J, Gilsanz F. A modified cord blood collection method achieves sufficient cell levels for transplantation in most adult patients. Stem Cells. 2005;23(3):324-34.
    • (2005) Stem Cells , vol.23 , Issue.3 , pp. 324-334
    • Bornstein, R.1    Flores, A.I.2    Montalban, M.A.3    Del Rey, M.J.4    De La Serna, J.5    Gilsanz, F.6
  • 15
    • 0028785797 scopus 로고
    • Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution
    • Rubinstein P, Dobrila L, Rosenfield RE, et al. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA. 1995; 92(22):10119-22.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.22 , pp. 10119-10122
    • Rubinstein, P.1    Dobrila, L.2    Rosenfield, R.E.3
  • 16
    • 8944228913 scopus 로고    scopus 로고
    • Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients
    • Kurtzberg J, Laughlin M, Graham ML, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med. 1996;335(3):157-66.
    • (1996) N Engl J Med , vol.335 , Issue.3 , pp. 157-166
    • Kurtzberg, J.1    Laughlin, M.2    Graham, M.L.3
  • 19
    • 14344258808 scopus 로고    scopus 로고
    • Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo
    • Levac K, Karanu F, Bhatia M. Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo. Haematologica. 2005;90(2):166-72.
    • (2005) Haematologica , vol.90 , Issue.2 , pp. 166-172
    • Levac, K.1    Karanu, F.2    Bhatia, M.3
  • 20
    • 38349121930 scopus 로고    scopus 로고
    • Signaling pathways governing stem-cell fate
    • Blank U, Karlsson G, Karlsson S. Signaling pathways governing stem-cell fate. Blood. 2008;111(2):492-503.
    • (2008) Blood , vol.111 , Issue.2 , pp. 492-503
    • Blank, U.1    Karlsson, G.2    Karlsson, S.3
  • 21
    • 0035383802 scopus 로고    scopus 로고
    • Umbilical cord blood cells capable of engrafting in primary, secondary, and tertiary xenogeneic hosts are preserved after ex vivo culture in a noncontact system
    • Lewis ID, Almeida-Porada G, Du J, et al. Umbilical cord blood cells capable of engrafting in primary, secondary, and tertiary xenogeneic hosts are preserved after ex vivo culture in a noncontact system. Blood. 2001;97(11):3441-9.
    • (2001) Blood , vol.97 , Issue.11 , pp. 3441-3449
    • Lewis, I.D.1    Almeida-Porada, G.2    Du, J.3
  • 22
    • 33845522237 scopus 로고    scopus 로고
    • Ex vivo expansion of umbilical cord blood stem cells for transplantation: Growing knowledge from the hematopoietic niche
    • Hofmeister CC, Zhang J, Knight KL, Le P, Stiff PJ. Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche. Bone Marrow Transplant. 2007;39(1):11-23.
    • (2007) Bone Marrow Transplant , vol.39 , Issue.1 , pp. 11-23
    • Hofmeister, C.C.1    Zhang, J.2    Knight, K.L.3    Le, P.4    Stiff, P.J.5
  • 23
    • 59449108838 scopus 로고    scopus 로고
    • Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin-and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice
    • Foguenne J, Di Stefano I, Giet O, Beguin Y, Gothot A. Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin-and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice. Haematologica. 2009;94(2):185-94.
    • (2009) Haematologica , vol.94 , Issue.2 , pp. 185-194
    • Foguenne, J.1    Di Stefano, I.2    Giet, O.3    Beguin, Y.4    Gothot, A.5
  • 24
    • 0034672254 scopus 로고    scopus 로고
    • Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G(2)/M transit and do not reenter G(0)
    • Glimm H, Oh IH, Eaves CJ. Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G(2)/M transit and do not reenter G(0). Blood. 2000;96(13):4185-93.
    • (2000) Blood , vol.96 , Issue.13 , pp. 4185-4193
    • Glimm, H.1    Oh, I.H.2    Eaves, C.J.3
  • 25
    • 0027233837 scopus 로고
    • Ex vivo expansion of hematopoietic stem and progenitor cells-robbing Peter to pay Paul?
    • Williams DA. Ex vivo expansion of hematopoietic stem and progenitor cells-robbing Peter to pay Paul? Blood. 1993; 81(12):3169-72.
    • (1993) Blood , vol.81 , Issue.12 , pp. 3169-3172
    • Williams, D.A.1
  • 26
    • 0035874515 scopus 로고    scopus 로고
    • The relative quiescence of hematopoietic stem cells in nonhuman primates
    • Mahmud N, Devine SM, Weller KP, et al. The relative quiescence of hematopoietic stem cells in nonhuman primates. Blood. 2001;97(10):3061-8.
    • (2001) Blood , vol.97 , Issue.10 , pp. 3061-3068
    • Mahmud, N.1    Devine, S.M.2    Weller, K.P.3
  • 27
    • 76349113345 scopus 로고    scopus 로고
    • Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution
    • Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med. 2010;16(2):232-6.
    • (2010) Nat Med , vol.16 , Issue.2 , pp. 232-236
    • Delaney, C.1    Heimfeld, S.2    Brashem-Stein, C.3    Voorhies, H.4    Manger, R.L.5    Bernstein, I.D.6
  • 28
    • 17944364269 scopus 로고    scopus 로고
    • A phase II trial evaluating the safety and effectiveness of the AastromReplicell system for augmentation of low-dose blood stem cell transplantation
    • Pecora AL, Stiff P, Lemaistre CF, et al. A phase II trial evaluating the safety and effectiveness of the AastromReplicell system for augmentation of low-dose blood stem cell transplantation. Bone Marrow Transplant. 2001;28(3):295-303.
    • (2001) Bone Marrow Transplant , vol.28 , Issue.3 , pp. 295-303
    • Pecora, A.L.1    Stiff, P.2    Lemaistre, C.F.3
  • 29
    • 0030932323 scopus 로고    scopus 로고
    • Long-term engraftment failure after marrow ablation and autologous hematopoietic reconstitution: Differences between peripheral blood stem cell and bone marrow recipients
    • Bentley SA, Brecher ME, Powell E, Serody JS, Wiley JM, Shea TC. Long-term engraftment failure after marrow ablation and autologous hematopoietic reconstitution: differences between peripheral blood stem cell and bone marrow recipients. Bone Marrow Transplant. 1997;19(6):557-63.
    • (1997) Bone Marrow Transplant , vol.19 , Issue.6 , pp. 557-563
    • Bentley, S.A.1    Brecher, M.E.2    Powell, E.3    Serody, J.S.4    Wiley, J.M.5    Shea, T.C.6
  • 30
    • 75149195195 scopus 로고    scopus 로고
    • Reduced-intensity conditioning and umbilical cord blood transplantation in adults
    • Cutler C, Ballen K. Reduced-intensity conditioning and umbilical cord blood transplantation in adults. Bone Marrow Transplant. 2009;44(10):667-71.
    • (2009) Bone Marrow Transplant , vol.44 , Issue.10 , pp. 667-671
    • Cutler, C.1    Ballen, K.2
  • 31
    • 0018102359 scopus 로고
    • The relationship between the spleen colony-forming cell and the haemopoietic stem cell
    • Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978; 4(1-2):7-25.
    • (1978) Blood Cells , vol.4 , Issue.1-2 , pp. 7-25
    • Schofield, R.1
  • 32
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003; 425(6960):836-41.
    • (2003) Nature , vol.425 , Issue.6960 , pp. 836-841
    • Zhang, J.1    Niu, C.2    Ye, L.3
  • 33
    • 77952660440 scopus 로고    scopus 로고
    • Effective ex vivo expansion of hematopoietic stem cells using osteoblast-differentiated mesenchymal stem cells is CXCL12 dependent
    • Mishima S, Nagai A, Abdullah S, et al. Effective ex vivo expansion of hematopoietic stem cells using osteoblast-differentiated mesenchymal stem cells is CXCL12 dependent. Eur J Haematol. 2010;84(6):538-46.
    • (2010) Eur J Haematol , vol.84 , Issue.6 , pp. 538-546
    • Mishima, S.1    Nagai, A.2    Abdullah, S.3
  • 34
    • 77449121923 scopus 로고    scopus 로고
    • Endothelial cells are essential for the self-renewal and repopulation of notch-dependent hematopoietic stem cells
    • Butler JM, Nolan DJ, Vertes EL, et al. Endothelial cells are essential for the self-renewal and repopulation of notch-dependent hematopoietic stem cells. Cell Stem Cell. 2010;6(3):251-64.
    • (2010) Cell Stem Cell , vol.6 , Issue.3 , pp. 251-264
    • Butler, J.M.1    Nolan, D.J.2    Vertes, E.L.3
  • 35
    • 77953573202 scopus 로고    scopus 로고
    • Systematic delineation of optimal cytokine concentrations to expand hematopoietic stem/progenitor cells in co-culture with mesenchymal stem cells
    • Andrade PZ, Dos Santos F, Almeida-Porada G, Da Silva CL, Jm SC. Systematic delineation of optimal cytokine concentrations to expand hematopoietic stem/progenitor cells in co-culture with mesenchymal stem cells. Mol Biosyst. 2010;6(7):1207-15.
    • (2010) Mol Biosyst , vol.6 , Issue.7 , pp. 1207-1215
    • Andrade, P.Z.1    Dos Santos, F.2    Almeida-Porada, G.3    Da Silva, C.L.4    Jm, S.C.5
  • 36
    • 18744376021 scopus 로고    scopus 로고
    • Stromal cellderived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro
    • Broxmeyer HE, Cooper S, Hangoc G, Kim CH. Stromal cellderived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. Stem Cells Dev. 2005;14(2):199-203.
    • (2005) Stem Cells Dev , vol.14 , Issue.2 , pp. 199-203
    • Broxmeyer, H.E.1    Cooper, S.2    Hangoc, G.3    Kim, C.H.4
  • 37
    • 4544271598 scopus 로고    scopus 로고
    • Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells
    • Mcniece I, Harrington J, Turney J, Kellner J, Shpall EJ. Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy. 2004;6(4):311-7.
    • (2004) Cytotherapy , vol.6 , Issue.4 , pp. 311-317
    • McNiece, I.1    Harrington, J.2    Turney, J.3    Kellner, J.4    Shpall, E.J.5
  • 38
    • 77954862944 scopus 로고    scopus 로고
    • CD3(?) and/or C 14(?) depletion from cord blood mononuclear cells before ex vivo expansion culture improves total nucleated cell and CD34(?) cell yields
    • Yang H, Robinson SN, Lu J et al. CD3(?) and/or CD14(?) depletion from cord blood mononuclear cells before ex vivo expansion culture improves total nucleated cell and CD34(?) cell yields. Bone Marrow Transplant. 2009;45:1000-7.
    • (2009) Bone Marrow Transplant , vol.45 , pp. 1000-1007
    • Yang, H.1    Robinson, S.N.2    Et Al., L.J.3
  • 39
    • 10744222172 scopus 로고    scopus 로고
    • Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: Results of a phase 1 trial using the AastromReplicell System
    • Jaroscak J, Goltry K, Smith A, et al. Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the AastromReplicell System. Blood. 2003;101(12):5061-7.
    • (2003) Blood , vol.101 , Issue.12 , pp. 5061-5067
    • Jaroscak, J.1    Goltry, K.2    Smith, A.3
  • 40
    • 0017694555 scopus 로고
    • Conditions controlling the proliferation of haemopoietic stem cells in vitro
    • Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol. 1977;91(3):335-44.
    • (1977) J Cell Physiol , vol.91 , Issue.3 , pp. 335-344
    • Dexter, T.M.1    Allen, T.D.2    Lajtha, L.G.3
  • 41
    • 0029131059 scopus 로고
    • Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects
    • Koller MR, Palsson MA, Manchel I, Palsson BO. Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects. Blood. 1995;86(5):1784-93.
    • (1995) Blood , vol.86 , Issue.5 , pp. 1784-1793
    • Koller, M.R.1    Palsson, M.A.2    Manchel, I.3    Palsson, B.O.4
  • 42
    • 0025782921 scopus 로고
    • Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells
    • Caldwell J, Palsson BO, Locey B, Emerson SG. Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells. J Cell Physiol. 1991;147(2):344-53.
    • (1991) J Cell Physiol , vol.147 , Issue.2 , pp. 344-353
    • Caldwell, J.1    Palsson, B.O.2    Locey, B.3    Emerson, S.G.4
  • 43
    • 18744415188 scopus 로고
    • Expansion of primitive human hematopoietic progenitors in a perfusion bioreactor system with IL-3, IL-6, and stem cell factor
    • Koller MR, Bender JG, Miller WM, Papoutsakis ET. Expansion of primitive human hematopoietic progenitors in a perfusion bioreactor system with IL-3, IL-6, and stem cell factor. Biotechnology (N Y). 1993;11(3):358-63.
    • (1993) Biotechnology (N Y) , vol.11 , Issue.3 , pp. 358-363
    • Koller, M.R.1    Bender, J.G.2    Miller, W.M.3    Papoutsakis, E.T.4
  • 44
  • 45
    • 0028212430 scopus 로고
    • Ahuman homologue of the Drosophila developmental gene, Notch, is expressed in CD34? hematopoietic precursors
    • Milner LA,Kopan R, Martin DI, Bernstein ID.Ahuman homologue of the Drosophila developmental gene, Notch, is expressed in CD34? hematopoietic precursors. Blood. 1994;83(8):2057-62.
    • (1994) Blood , vol.83 , Issue.8 , pp. 2057-2062
    • Milner, L.A.1    Kopan, R.2    Martin, D.I.3    Bernstein, I.D.4
  • 46
    • 0034613734 scopus 로고    scopus 로고
    • The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
    • Karanu FN, Murdoch B, Gallacher L, et al. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J Exp Med. 2000;192(9):1365-72.
    • (2000) J Exp Med , vol.192 , Issue.9 , pp. 1365-1372
    • Karanu, F.N.1    Murdoch, B.2    Gallacher, L.3
  • 47
    • 0035313174 scopus 로고    scopus 로고
    • Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells
    • Karanu FN, Murdoch B, Miyabayashi T, et al. Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells. Blood. 2001;97(7):1960-7.
    • (2001) Blood , vol.97 , Issue.7 , pp. 1960-1967
    • Karanu, F.N.1    Murdoch, B.2    Miyabayashi, T.3
  • 48
    • 0036802174 scopus 로고    scopus 로고
    • Delta-1 enhances marrow and thymus repopulating ability of human CD34(?)C 38(-) cord blood cells
    • Ohishi K, Varnum-Finney B, Bernstein ID. Delta-1 enhances marrow and thymus repopulating ability of human CD34(?)CD38(-) cord blood cells. J Clin Invest. 2002;110(8):1165-74.
    • (2002) J Clin Invest , vol.110 , Issue.8 , pp. 1165-1174
    • Ohishi, K.1    Varnum-Finney, B.2    Bernstein, I.D.3
  • 49
    • 27144518462 scopus 로고    scopus 로고
    • Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells
    • Delaney C, Varnum-Finney B, Aoyama K, Brashem-Stein C, Bernstein ID. Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood. 2005;106(8):2693-9.
    • (2005) Blood , vol.106 , Issue.8 , pp. 2693-2699
    • Delaney, C.1    Varnum-Finney, B.2    Aoyama, K.3    Brashem-Stein, C.4    Bernstein, I.D.5
  • 50
    • 0242268524 scopus 로고    scopus 로고
    • Osteoblastic cells regulate the haematopoietic stem cell niche
    • Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841-6.
    • (2003) Nature , vol.425 , Issue.6960 , pp. 841-846
    • Calvi, L.M.1    Adams, G.B.2    Weibrecht, K.W.3
  • 51
    • 0032212190 scopus 로고    scopus 로고
    • Role of members of the Wnt gene family in human hematopoiesis
    • Van Den Berg DJ, Sharma AK, Bruno E, Hoffman R. Role of members of the Wnt gene family in human hematopoiesis. Blood. 1998;92(9):3189-202.
    • (1998) Blood , vol.92 , Issue.9 , pp. 3189-3202
    • Van Den Berg, D.J.1    Sharma, A.K.2    Bruno, E.3    Hoffman, R.4
  • 52
    • 79955608017 scopus 로고    scopus 로고
    • Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway
    • Heinonen KM, Vanegas JR, Lew D, Krosl J, Perreault C. Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS One. 2011;6(4):e19279.
    • (2011) PLoS One , vol.6 , Issue.4
    • Heinonen, K.M.1    Vanegas, J.R.2    Lew, D.3    Krosl, J.4    Perreault, C.5
  • 53
    • 20144370145 scopus 로고    scopus 로고
    • Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
    • Duncan AW, Rattis FM, Dimascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6(3):314-22.
    • (2005) Nat Immunol , vol.6 , Issue.3 , pp. 314-322
    • Duncan, A.W.1    Rattis, F.M.2    Dimascio, L.N.3
  • 54
    • 79959356519 scopus 로고    scopus 로고
    • Future perspectives: Therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies
    • Ersvaer E, Hatfield K, Reikvam H, Bruserud O. Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies. Bone marrow research. 2011;2011:570796.
    • (2011) Bone Marrow Research , vol.2011 , pp. 570796
    • Ersvaer, E.1    Hatfield, K.2    Reikvam, H.3    Bruserud, O.4
  • 55
    • 38149050613 scopus 로고    scopus 로고
    • The role of angiopoietin-like proteins in angiogenesis and metabolism
    • Hato T, Tabata M, Oike Y. The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc Med. 2008;18(1):6-14.
    • (2008) Trends Cardiovasc Med , vol.18 , Issue.1 , pp. 6-14
    • Hato, T.1    Tabata, M.2    Oike, Y.3
  • 56
    • 1642371165 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells
    • Zhang CC, Lodish HF. Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood. 2004;103(7):2513-21.
    • (2004) Blood , vol.103 , Issue.7 , pp. 2513-2521
    • Zhang, C.C.1    Lodish, H.F.2
  • 57
    • 77952400247 scopus 로고    scopus 로고
    • Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells
    • Chou S, Lodish HF. Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. Proc Natl Acad Sci USA. 2010;107(17):7799-804.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.17 , pp. 7799-7804
    • Chou, S.1    Lodish, H.F.2
  • 58
    • 32244436673 scopus 로고    scopus 로고
    • Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells
    • Zhang CC, Kaba M, Ge G, et al. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med. 2006;12(2):240-5.
    • (2006) Nat Med , vol.12 , Issue.2 , pp. 240-245
    • Zhang, C.C.1    Kaba, M.2    Ge, G.3
  • 59
    • 43549113659 scopus 로고    scopus 로고
    • Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation
    • Zhang CC, Kaba M, Iizuka S, Huynh H, Lodish HF. Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood. 2008;111(7):3415-23.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3415-3423
    • Zhang, C.C.1    Kaba, M.2    Iizuka, S.3    Huynh, H.4    Lodish, H.F.5
  • 60
    • 0034892945 scopus 로고    scopus 로고
    • HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation
    • Antonchuk J, Sauvageau G, Humphries RK. HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp Hematol. 2001;29(9):1125-34.
    • (2001) Exp Hematol , vol.29 , Issue.9 , pp. 1125-1134
    • Antonchuk, J.1    Sauvageau, G.2    Humphries, R.K.3
  • 61
    • 77952926824 scopus 로고    scopus 로고
    • Purified recombinant TATHOXB4 expands CD34? umbilical cord blood and peripheral blood progenitor cells ex vivo
    • Huang CH, Chen PM, Lu TC et al. Purified recombinant TATHOXB4 expands CD34? umbilical cord blood and peripheral blood progenitor cells ex vivo. Tissue Eng Part C Methods. 2009;16(3):487-96.
    • (2009) Tissue Eng Part C Methods , vol.16 , Issue.3 , pp. 487-496
    • Huang, C.H.1    Chen, P.M.2    Lu, T.C.3
  • 62
    • 77956269498 scopus 로고    scopus 로고
    • Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells
    • Lee HM, Zhang H, Schulz V, Tuck DP, Forget BG. Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells. Blood. 2010;116(5):720-30.
    • (2010) Blood , vol.116 , Issue.5 , pp. 720-730
    • Lee, H.M.1    Zhang, H.2    Schulz, V.3    Tuck, D.P.4    Forget, B.G.5
  • 63
    • 33746508365 scopus 로고    scopus 로고
    • Megakaryocyte development and platelet production
    • Deutsch VR, Tomer A. Megakaryocyte development and platelet production. Br J Haematol. 2006;134(5):453-66.
    • (2006) Br J Haematol , vol.134 , Issue.5 , pp. 453-466
    • Deutsch, V.R.1    Tomer, A.2
  • 64
    • 0028827190 scopus 로고
    • Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro
    • Ezumi Y, Takayama H, Okuma M. Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro. FEBS Lett. 1995;374(1):48-52.
    • (1995) FEBS Lett , vol.374 , Issue.1 , pp. 48-52
    • Ezumi, Y.1    Takayama, H.2    Okuma, M.3
  • 65
    • 0033566712 scopus 로고    scopus 로고
    • Thrombopoietininduced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: Role in endomitosis
    • Rojnuckarin P, Drachman JG, Kaushansky K. Thrombopoietininduced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. Blood. 1999;94(4):1273-82.
    • (1999) Blood , vol.94 , Issue.4 , pp. 1273-1282
    • Rojnuckarin, P.1    Drachman, J.G.2    Kaushansky, K.3
  • 66
    • 0038468754 scopus 로고    scopus 로고
    • Thrombopoietin: Accumulating evidence for an important biological effect on the hematopoietic stem cell
    • Kaushansky K. Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell. Ann N Y Acad Sci. 2003;996:39-43.
    • (2003) Ann N y Acad Sci , vol.996 , pp. 39-43
    • Kaushansky, K.1
  • 67
    • 67749147173 scopus 로고    scopus 로고
    • Common features of megakaryocytes and hematopoietic stem cells: What's the connection?
    • Huang H, Cantor AB. Common features of megakaryocytes and hematopoietic stem cells: what's the connection? J Cell Biochem. 2009;107(5):857-64.
    • (2009) J Cell Biochem , vol.107 , Issue.5 , pp. 857-864
    • Huang, H.1    Cantor, A.B.2
  • 68
    • 36749001043 scopus 로고    scopus 로고
    • Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
    • Qian H, Buza-Vidas N, Hyland CD, et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell. 2007;1(6):671-84.
    • (2007) Cell Stem Cell , vol.1 , Issue.6 , pp. 671-684
    • Qian, H.1    Buza-Vidas, N.2    Hyland, C.D.3
  • 69
    • 70349836514 scopus 로고    scopus 로고
    • Niche regulation of hematopoietic stem cells in the endosteum
    • Arai F, Yoshihara H, Hosokawa K, et al. Niche regulation of hematopoietic stem cells in the endosteum. Ann N Y Acad Sci. 2009;1176:36-46.
    • (2009) Ann N y Acad Sci , vol.1176 , pp. 36-46
    • Arai, F.1    Yoshihara, H.2    Hosokawa, K.3
  • 70
    • 0030014681 scopus 로고    scopus 로고
    • The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells
    • Sitnicka E, Lin N, Priestley GV, et al. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood. 1996;87(12):4998-5005.
    • (1996) Blood , vol.87 , Issue.12 , pp. 4998-5005
    • Sitnicka, E.1    Lin, N.2    Priestley, G.V.3
  • 71
    • 70349832417 scopus 로고    scopus 로고
    • Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL
    • e1364
    • Nishino T, Miyaji K, Ishiwata N et al. Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL. Exp Hematol. 2009;37(11):1364-77 e1364.
    • (2009) Exp Hematol , vol.37 , Issue.11 , pp. 1364-1377
    • Nishino, T.1    Miyaji, K.2    Et Al., I.N.3
  • 72
    • 28844498633 scopus 로고    scopus 로고
    • Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain
    • Bakshi A, Keck CA, Koshkin VS, et al. Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain. Brain Res. 2005;1065(1-2):8-19.
    • (2005) Brain Res , vol.1065 , Issue.1-2 , pp. 8-19
    • Bakshi, A.1    Keck, C.A.2    Koshkin, V.S.3
  • 73
    • 77957887644 scopus 로고    scopus 로고
    • Expansion of cord blood CD34? cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse
    • Sangeetha VM, Kale VP, Limaye LS. Expansion of cord blood CD34? cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse. PLoS One. 2010;5(8):e12221.
    • (2010) PLoS One , vol.5 , Issue.8
    • Sangeetha, V.M.1    Kale, V.P.2    Limaye, L.S.3
  • 74
    • 79956352798 scopus 로고    scopus 로고
    • The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche
    • Luo B, Lam BS, Lee SH, et al. The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLoS One. 2011;6(5):e20364.
    • (2011) PLoS One , vol.6 , Issue.5
    • Luo, B.1    Lam, B.S.2    Lee, S.H.3
  • 75
    • 79953885122 scopus 로고    scopus 로고
    • Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models
    • Goessling W, Allen RS, Guan X, et al. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell. 2011;8(4):445-58.
    • (2011) Cell Stem Cell , vol.8 , Issue.4 , pp. 445-458
    • Goessling, W.1    Allen, R.S.2    Guan, X.3
  • 76
    • 77956519710 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
    • Boitano AE, Wang J, Romeo R, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010;329(5997):1345-8.
    • (2010) Science , vol.329 , Issue.5997 , pp. 1345-1348
    • Boitano, A.E.1    Wang, J.2    Romeo, R.3
  • 77
    • 31844449339 scopus 로고    scopus 로고
    • Expansion of human umbilical cord blood SCID-repopulating cells using chromatinmodifying agents
    • Araki H, Mahmud N, Milhem M, et al. Expansion of human umbilical cord blood SCID-repopulating cells using chromatinmodifying agents. Exp Hematol. 2006;34(2):140-9.
    • (2006) Exp Hematol , vol.34 , Issue.2 , pp. 140-149
    • Araki, H.1    Mahmud, N.2    Milhem, M.3
  • 78
    • 77953365022 scopus 로고    scopus 로고
    • Decitabine maintains hematopoietic precursor self-renewal by preventing repression of stem cell genes by a differentiation-inducing stimulus
    • Hu Z, Negrotto S, Gu X, et al. Decitabine maintains hematopoietic precursor self-renewal by preventing repression of stem cell genes by a differentiation-inducing stimulus. Mol Cancer Ther. 2010;9(6):1536-43.
    • (2010) Mol Cancer Ther , vol.9 , Issue.6 , pp. 1536-1543
    • Hu, Z.1    Negrotto, S.2    Gu, X.3
  • 79
    • 58149387546 scopus 로고    scopus 로고
    • Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serum-free conditions
    • Seet LF, Teng E, Lai YS, et al. Valproic acid enhances the engraftability of human umbilical cord blood hematopoietic stem cells expanded under serum-free conditions. Eur J Haematol. 2009;82(2):124-32.
    • (2009) Eur J Haematol , vol.82 , Issue.2 , pp. 124-132
    • Seet, L.F.1    Teng, E.2    Lai, Y.S.3
  • 80
    • 80052632061 scopus 로고    scopus 로고
    • Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase
    • Nishino T, Wang C, Mochizuki-Kashio M, Osawa M, Nakauchi H, Iwama A. Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One. 2011;6(9):e24298.
    • (2011) PLoS One , vol.6 , Issue.9
    • Nishino, T.1    Wang, C.2    Mochizuki-Kashio, M.3    Osawa, M.4    Nakauchi, H.5    Iwama, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.