Corallopyronin a specifically targets and depletes essential obligate wolbachia endobacteria from filarial nematodes in vivo

Journal of Infectious Diseases

Volumn 206, Issue 2, 2012, Pages 249-257

  Schiefer, Andrea ^a   Schmitz, Alexander ^b   Schäberle, Till F ^b   Specht, Sabine ^a   Lämmer, Christine ^a   Johnston, Kelly L ^c   Vassylyev, Dmitry G ^d   König, Gabriele M ^b   Hoerauf, Achim ^a   Pfarr, Kenneth ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CORALLOPYRONIN A; DOXYCYCLINE HYCLATE; MYXOPYRONIN A; RIFAMPICIN; RNA POLYMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHELMINTIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORALLOCOCCUS CORALLOIDES; CROSS RESISTANCE; DRUG DETERMINATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TREATMENT FAILURE; ENZYME INHIBITION; FEMALE; FILARIA; FILARIASIS; IN VITRO STUDY; IN VIVO STUDY; INSECT CELL; INTRACELLULAR BACTERIUM; LARVAL DEVELOPMENT; MOUSE; MYCOBACTERIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PRIORITY JOURNAL; TARGET ORGANISM; TREATMENT DURATION; WOLBACHIA;

AEDES; ANIMALS; CELL LINE; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; FEMALE; FILARIASIS; FILARICIDES; FILARIOIDEA; LACTONES; MICE; MICE, INBRED BALB C; MOLECULAR CONFORMATION; RIFAMPIN; SYMBIOSIS; WOLBACHIA;

EID: 84862855021     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis341     Document Type: Article

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