The CB 1 receptor-mediated endocannabinoid signaling and NGF: The novel targets of curcumin

Neurochemical Research

Volumn 37, Issue 5, 2012, Pages 1112-1120

  Hassanzadeh, Parichehr ^a   Hassanzadeh, Anna ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Amitriptyline; Brain; CB 1 receptors; CB 2 receptors; Curcumin; Endocannabinoid system; NGF; Rat

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; AMITRIPTYLINE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR ANTAGONIST; CURCUMIN; NERVE GROWTH FACTOR;

AMYGDALOID NUCLEUS; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; BRAIN TISSUE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EXTRACTION; FRONTAL CORTEX; HIPPOCAMPUS; MALE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

AMITRIPTYLINE; ANIMALS; BRAIN; CURCUMIN; ENDOCANNABINOIDS; MALE; NERVE GROWTH FACTOR; PYRAZOLES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84862840833     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0716-2     Document Type: Article

References (58)

1. Riolo SA, Nguyen TA, Greden JF, King CA (2005) Prevalence of depression by race/ethnicity: findings from the national health and nutrition examination survey III. Am J Public Health 95(6): 998-1000 (Pubitemid 40740711)
2. Ereshefsky L (2009) Drug-drug interactions with the use of psychotropic medications: questions and answers. CNS Spectr 14(8):1-8
3. Nemeroff CB (2007) The burden of severe depression: a review of diagnostic challenges and treatment alternatives. J Psychiatr Res 41:189-206 (Pubitemid 44854991)
4. van der Watt G, Laugharne J, Janca A (2008) Complementary and alternative medicine in the treatment of anxiety and depression. Curr Opin Psychiatry 21(1):37-42 (Pubitemid 351339806)
5. Zhou H, Beevers CS, Huang S (2011) The targets of curcumin. Curr Drug Targets 12:332-347
6. Chainani-Wu N (2003) Safety and anti-inflammatory activity of curcumin: a component of turmeric (curcuma longa). J Alternative Compl Med 9:161-168 (Pubitemid 36297021)
7. Maheshwari RK, Singh AK, Gaddipati J, Smiral RC (2006) Multiple biological activities of curcumin: a short review. Life Sci 78:2081-2087
8. Aggarwal BB, Harikumar KB (2009) Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41:40-59
9. Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH et al (2005) The effects of curcumin on depressive-like behaviors in mice. Eur J Pharmacol 518:40-46 (Pubitemid 40968146)
10. Xu Y, Ku BS, Yao HY, Lin YH, Ma X, Zhang YH et al (2005) Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem Behav 82:200-206 (Pubitemid 41423504)
11. Kulkarni SK, Bhutani MK, Bishnoi M (2008) Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl) 201:435-442
12. Berton O, Nestler EJ (2006) New approaches to antidepressant drug discovery: Beyond monoamines. Nat Rev Neurosci 7: 137-151 (Pubitemid 43151600)
13. Tanis KQ, Duman RS (2007) Intracellular signaling pathways pave roads to recovery for mood disorders. Ann Med 39:531-544 (Pubitemid 350035570)
14. Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Ann Rev Neurosci 24:677-736 (Pubitemid 32695243)
15. Castren E, Voikar V, Rantamaki T (2007) Role of neurotrophic factors in depression. Curr Opin Pharmacol 7(1):18-21 (Pubitemid 46238033)
16. Shaltiel G, Chen G, Manji HK (2007) Neurotrophic signalling cascades in the pathophysiology and treatment of bipolar disorder. Curr Opin Pharmacol 7:22-26 (Pubitemid 46238034)
17. Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM (2008) Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 63:642-649 (Pubitemid 351329281)
18. Xu Y, Ku B, Cui L, Li X, Barish PA, Foster TC et al (2007) Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain derived neurotrophic factor expression in chronically stressed rats. Brain Res 1162:9-18 (Pubitemid 47088372)
19. Wang R, Li YB, Li YH, Xu Y, Wu H, Li XJ (2008) Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res 1210:84-91
20. Ebendal T (1992) Function and evolution in the NGF family and its receptors. J Neurosci Res 32:461-470
21. Lad SP, Neet KE, Mufson EJ (2003) Nerve growth factor: structure, function and therapeutic implications for Alzheimer's disease. Curr Drug Targets CNS Neurol Disord 2:315-334
22. Alleva E, Petruzzi S, Cirulli F, Aloe L (1996) NGF regulatory role in stress and coping of rodents and humans. Pharmacol Biochem Behav 54(1):65-72 (Pubitemid 26143092)
23. Jang SW, Liu X, Chan CB, Weinshenker D, Hall RA, Xiao G et al (2009) The antidepressant amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol 16:644-656
24. Chadwick W, Mitchell N, Caroll J, Zhou Y, Park SS, Wang L et al (2011) Amitriptyline-mediated cognitive enhancement in aged 3 × Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. Plos One 6:e21660
25. Viveros MP, Marco EM, File SE (2005) Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav 81(2):331-342 (Pubitemid 40807131)
26. Viveros MP, Marco EM, Liorente R, Lopez-Gallardo M (2007) Endocannabinoid system and synaptic plasticity: implication for emotional response. Neural Plast 2007:52908
27. Bambico FR, Duranti A, Tontini A, Tarzia G, Gobbi G (2009) Endocannabinoids in the treatment of mood disorders: evidence from animal models. Curr Pharm Des 15(14):1623-1646
28. Rodríguez-Gaztelumendi A, Rojo ML, Pazos A, Díaz A (2009) Altered CB1 receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine. J Neurochem 108(6):1423-1433
29. Williams EJ, Walsh FS, Doherty P (2003) The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response. J Cell Biol 160:481-486 (Pubitemid 36254386)
30. Khaspekov LG, Brenz Verca MS, Frumkina LE, Hermann H, Marsicano G, Lutz B (2004) Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity. Eur J Neurosci 19:1691-1698 (Pubitemid 38482557)
31. Ghoneim AI, Abdel-Naim AB, Khalifa AE, El-Denshary ES (2002) Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Pharmacol Res 46:273-279 (Pubitemid 35300767)
32. Li Yu-Cheng, Wang Fu-Meng, Pan Ying, Qiang Li-Qin, Cheng Guang, Zhang Wei-Yun et al (2009) Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry 33(3):435-449
33. di Matteo V, di Mascio M, di Giovanni G, Esposito E (2000) Acute administration of amitriptyline and mianserin increases dopamine release in the rat nucleus accumbens: possible involvement of serotonin 2C receptors. Psychopharmacology (Berl) 150:45-51 (Pubitemid 30350812)
34. Järbe TU, LeMay BJ, Olszewska T, Vemuri VK, Wood JT, Makriyannis A (2008) Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviours in rats. Pharmacol Biochem Behav 91(1):84-90
35. Sink KS, McLaughlin PJ, Wood JA, Brown C, Fan P, Vemuri VK et al (2008) The novel cannabinoid CB (1) receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology 33:946-955 (Pubitemid 351252707)
36. Abalo R, Cabezos PA, Vera G, Fernandez-pujol R, Martin MI (2010). The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212-2 on gastrointestinal motility in the rat. Neurogastroenterol Motil 22(6): 694-e206
37. Gwinn RP, Kondratyev A, Gale K (2002) Time-dependent increase in basic fibroblast growth factor protein in limbic regions following electroshock seizures. Neuroscience 114:403-409 (Pubitemid 35245419)
38. Vinay P, KhanMohammad M, Alvin T, Sahebarao PM (2004) Differential effects of typical and atypical antipsychotics on nerve growth factor and choline acetyltransferase expression in the cortex and nucleus basalis of rats. J Psychiat Res 38(5):521-529
39. Paxinos G, Watson C (1997) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego
40. Hoener MC, Hewitt E, Conner JM, Costello JW, Varon S (1996) Nerve growth factor (NGF) content in adult rat brain tissues is several-fold higher than generally reported and is largely associated with sedimentable fractions. Brain Res 728:47-56 (Pubitemid 26254955)
41. Hellweg R, Hock C, Hartung HD (1989) An improved rapid and highly sensitive enzyme immunoassay for nerve growth factor. Technique J Meth Cell Mol Biol 1:43-49
42. Hellweg R, Thomas H, Arnswald A, von Richthofen S, Kay S, Fink H et al (2001) Serotonergic lesion of median raphe nucleus alters nerve growth factor content and vulnerability of cholinergic septohippocampal neurons in rat. Brain Res 907:100-108 (Pubitemid 32595516)
43. Hellweg R, Lang UE, Nagel M, Baumgartner A (2002) Subchronic treatment with lithium increases nerve growth factor content in distinct brain regions of adult rats. Mol Psychiatry 7:604-608
44. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
45. de Lago E, Petrosino S, Valenti M, Morera E, Ortega-Gutierrez S, Fernandez-Ruiz J et al (2005) Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels. Biochem Pharmacol 70:446-452 (Pubitemid 40905116)
46. Koga D, Santa T, Fukushima T, Homma H, Imai K (1997) Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric determination of anandamide and its analogues in rat brain and peripheral tissues. J Chromatogr B Biomed Sci Appl 690:7-13 (Pubitemid 27136450)
47. Patel S, Rademacher DJ, Hillard CJ (2003) Differential regulation of the endocannabinoids anandamide and 2-Arachidonylglycerol within the limbic forebrain by dopamine receptor activity. J Pharmacol Exp Ther 306:880-888 (Pubitemid 37025293)
48. Hassanzadeh P, Hassanzadeh A (2010) Effects of different psychotropic agents on the central nerve growth factor protein. Iran J Basic Med Sci 13(1):202-209
49. Yanpallewar SU, Fernandes K, Marathe SV, Vadodaria KC, Jhaveri D, Rommelfanger K et al (2010) α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. J Neurosci 30(3):1096-1109
50. Cheng S, Ma M, Ma Y, Wang Z, Xu G, Liu X (2009) Combination therapy with intranasal NGF and electroacupuncture enhanced cell proliferation and survival in rats after stroke. Neurol Res 31(7):753-758
51. Banasr M, Valentine GW, Li XY, Gourley SL, Taylor JR, Duman RS (2007) Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat. Biol Psychiatry 62(5):496-504 (Pubitemid 47284039)
52. Conner JM, Franks KM, Titterness AK, Russell K, Merrill DA, Christie BR et al (2009) NGF is essential for hippocampal plasticity and learning. J Neurosci 29(35):10883-10889
53. Winkler J, Ramirez GA, Thal LJ, Waite JJ (2000) Nerve growth factor (NGF) augments cortical and hippocampal cholinergic functioning after p75NGF receptor-mediated deafferentation but impairs inhibitory avoidance and induces fear-related behaviors. J Neurosci 20(2):834-844 (Pubitemid 30225586)
54. Moises HC, Womble MD, Washburn MS, Williams LR (1995) Nerve growth factor facilitates cholinergic neurotransmission between nucleus basalis and the amygdala in rat: an electrophysiological analysis. J Neurosci 15(12):8131-8142 (Pubitemid 26006917)
55. Miwa T, Moriizumi T, Horikawa I, Uramoto N, Ishimaru T, Nishimura T et al (2002) Role of nerve growth factor in the olfactory system. Microsc Res Tech 58(3):197-203 (Pubitemid 34832825)
56. Marsicano G, Lutz B (2006) Neuromodulatory functions of the endocannabinoid system. J Endocrinol Investig 29(3):27-46
57. Hankoff LD, Peress NS (1981) Neuropathology of the brain stem in psychiatric disorders. Biol Psychiatry 16(10):945-952 (Pubitemid 12233786)
58. Teiten MH, Eifes S, Dicato M, Diederich M (2010) Curcumin - The paradigm of a multi-target natural compound with applications in cancer prevention and treatment. Toxins 2:128-162