The kindlins at a glance

Journal of Cell Science

Volumn 123, Issue 14, 2010, Pages 2353-2356

  Karaköse, Esra ^a   Schiller, Herbert B ^a   Fässler, Reinhard ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; KINDLIN 1; KINDLIN 2; KINDLIN 3; UNCLASSIFIED DRUG;

HUMAN; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; ANIMALS; CONGENITAL ABNORMALITIES; CYTOSKELETON; FOCAL ADHESIONS; HUMANS; INTEGRINS; MEMBRANE PROTEINS; MUTATION; NEOPLASM PROTEINS; ORGAN SPECIFICITY; PROTEIN BINDING; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 77954896824     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.064600     Document Type: Short Survey

References (47)

1. Akazawa, H., Kudoh, S., Mochizuki, N., Takekoshi, N., Takano, H., Nagai, T. and Komuro, I. (2004). A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. J. Cell Biol. 164, 395-405. (Pubitemid 38174767)
2. Bai, J., Binari, R., Ni, J. Q., Vijayakanthan, M., Li, H. S. and Perrimon, N. (2008). RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development 135, 1439-1449. (Pubitemid 351753634)
3. Bialkowska, K., Ma, Y. Q., Bledzka, K., Sossey-Alaoui, K., Izem, L., Zhang, X., Malinin, N., Qin, J., Byzova, T. and Plow, E. F. (2010). The integrin co-activator kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell. J Biol. Chem. Epub ahead of print.
4. Bottcher, R. T., Lange, A. and Fassler, R. (2009). How ILK and kindlins cooperate to orchestrate integrin signaling. Curr. Opin. Cell Biol. 21, 670-675.
5. Bouaouina, M., Lad, Y. and Calderwood, D. A. (2008). The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins. J. Biol. Chem. 283, 6118-6125.
6. Dowling, J. J., Gibbs, E., Russell, M., Goldman, D., Minarcik, J., Golden, J. A. and Feldman, E. L. (2008a). Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function. Circ. Res. 102, 423-431.
7. Dowling, J. J., Vreede, A. P., Kim, S., Golden, J. and Feldman, E. L. (2008b). Kindlin-2 is required for myocyte elongation and is essential for myogenesis. BMC Cell Biol. 9, 36.
8. Etzioni, A. (2009). Genetic etiologies of leukocyte adhesion defects. Curr. Opin. Immunol. 21, 481-486.
9. Goult, B. T., Bouaouina, M., Harburger, D. S., Bate, N., Patel, B., Anthis, N. J., Campbell, I. D., Calderwood, D. A., Barsukov, I. L., Roberts, G. C. et al. (2009a). The structure of the N-terminus of kindlin-1: a domain important for alphaIIbbeta3 integrin activation. J. Mol. Biol. 394, 944-956.
10. Goult, B. T., Bouaouina, M., Harburger, D. S., Bate, N., Patel, B., Anthis, N. J., Campbell, I. D., Calderwood, D. A., Barsukov, I. L., Roberts, G. C. et al. (2009b). The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation. J. Mol. Biol. 394, 944-956.
11. Harburger, D. S., Bouaouina, M. and Calderwood, D. A. (2009). Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J. Biol. Chem. 284, 11485-11497.
12. Has, C., Herz, C., Zimina, E., Qu, H. Y., He, Y., Zhang, Z. G., Wen, T. T., Gache, Y., Aumailley, M. and Bruckner-Tuderman, L. (2009). Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes. Am. J. Pathol. 175, 1442-1452.
13. Hruz, T., Laule, O., Szabo, G., Wessendorp, F., Bleuler, S., Oertle, L., Widmayer, P., Gruissem, W. and Zimmermann, P. (2008). Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes. Adv. Bioinformatics 2008, 420747.
14. Hynes, R. O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
15. Jobard, F., Bouadjar, B., Caux, F., Hadj-Rabia, S., Has, C., Matsuda, F., Weissenbach, J., Lathrop, M., Prud'homme, J. F. and Fischer, J. (2003). Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome. Hum. Mol. Gen. 12, 925-935.
16. Kato, K., Shiozawa, T., Mitsushita, J., Toda, A., Horiuchi, A., Nikaido, T., Fujii, S. and Konishi, I. (2004). Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas. Hum. Pathol. 35, 55-60.
17. Kern, J. S., Herz, C., Haan, E., Moore, D., Nottelmann, S., von Lilien, T., Greiner, P., Schmitt-Graeff, A., Opitz, O. G., Bruckner-Tuderman, L. et al. (2007). Chronic colitis due to an epithelial barrier defect: the role of kindlin-1 isoforms. J. Pathol. 213, 462-470.
18. Kilic, S. S. and Etzioni, A. (2009). The clinical spectrum of leukocyte adhesion deficiency (LAD) III due to defective CalDAG-GEF1. J. Clin. Immunol. 29, 117-122.
19. Kruger, M., Moser, M., Ussar, S., Thievessen, I., Luber, C. A., Forner, F., Schmidt, S., Zanivan, S., Fassler, R. and Mann, M. (2008). SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell 134, 353-364.
20. Kuijpers, T. W., van de Vijver, E., Weterman, M. A., de Boer, M., Tool, A. T., van den Berg, T. K., Moser, M., Jakobs, M. E., Seeger, K., Sanal, O. et al. (2009). LAD-1/variant syndrome is caused by mutations in FERMT3. Blood 113, 4740-4746.
21. Lai-Cheong, J. E., Ussar, S., Arita, K., Hart, I. R. and McGrath, J. A. (2008). Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. J. Invest. Dermatol. 128, 2156-2165.
22. Lai-Cheong, J. E., Parsons, M. and McGrath, J. A. (2009). The role of kindlins in cell biology and relevance to human disease. Int. J. Biochem. Cell Biol. 42, 595-603.
23. Lange, A., Wickstrom, S. A., Jakobson, M., Zent, R., Sainio, K. and Fassler, R. (2009). Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461, 1002-1006.
24. Legate, K. R., Wickstrom, S. A. and Fassler, R. (2009). Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev. 23, 397-418.
25. Ma, Y. Q., Qin, J., Wu, C. and Plow, E. F. (2008). Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J. Cell Biol. 181, 439-446.
26. Mackinnon, A. C., Qadota, H., Norman, K. R., Moerman, D. G. and Williams, B. D. (2002). C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. Curr. Biol. 12, 787-797.
27. Malinin, N. L., Zhang, L., Choi, J., Ciocea, A., Razorenova, O., Ma, Y. Q., Podrez, E. A., Tosi, M., Lennon, D. P., Caplan, A. I. et al. (2009). A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat. Med. 15, 313-318.
28. Manevich-Mendelson, E., Feigelson, S. W., Pasvolsky, R., Aker, M., Grabovsky, V., Shulman, Z., Kilic, S. S., Rosenthal-Allieri, M. A., Ben-Dor, S., Mory, A. et al. (2009). Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions. Blood 114, 2344-2353.
29. McDowall, A., Svensson, L., Stanley, P., Patzak, I., Chakravarty, P., Howarth, K., Sabnis, H., Briones, M. and Hogg, N. (2010). Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency-III patient reveal distinct effects on leukocyte function in vitro. Blood Epub ahead of print.
30. Meves, A., Stremmel, C., Gottschalk, K. and Fassler, R. (2009). The Kindlin protein family: new members to the club of focal adhesion proteins. Trends Cell Biol. 19, 504-513.
31. Montanez, E., Ussar, S., Schifferer, M., Bosl, M., Zent, R., Moser, M. and Fassler, R. (2008). Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 22, 1325-1330. (Pubitemid 351717522)
32. Moser, M., Nieswandt, B., Ussar, S., Pozgajova, M. and Fassler, R. (2008). Kindlin-3 is essential for integrin activation and platelet aggregation. Nat. Med. 14, 325-330.
33. Moser, M., Bauer, M., Schmid, S., Ruppert, R., Schmidt, S., Sixt, M., Wang, H. V., Sperandio, M. and Fassler, R. (2009a). Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat. Med. 15, 300-305.
34. Moser, M., Legate, K. R., Zent, R. and Fassler, R. (2009b). The tail of integrins, talin, and kindlins. Science 324, 895-899.
35. Pasini, E. M., Kirkegaard, M., Mortensen, P., Lutz, H. U., Thomas, A. W. and Mann, M. (2006). In-depth analysis of the membrane and cytosolic proteome of red blood cells. Blood 108, 791-801. (Pubitemid 44154609)
36. Plow, E. F., Qin, J. and Byzova, T. (2009). Kindling the flame of integrin activation and function with kindlins. Curr. Opin. Hematol. 16, 323-328.
37. Rogalski, T. M., Mullen, G. P., Gilbert, M. M., Williams, B. D. and Moerman, D. G. (2000). The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane. J. Cell Biol. 150, 253-264.
38. Sakai, T., Li, S., Docheva, D., Grashoff, C., Sakai, K., Kostka, G., Braun, A., Pfeifer, A., Yurchenco, P. D. and Fassler, R. (2003). Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 17, 926-940. (Pubitemid 36397379)
39. Siegel, D. H., Ashton, G. H., Penagos, H. G., Lee, J. V., Feiler, H. S., Wilhelmsen, K. C., South, A. P., Smith, F. J., Prescott, A. R., Wessagowit, V. et al. (2003). Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am. J. Hum. Genet. 73, 174-187.
40. Svensson, L., Howarth, K., McDowall, A., Patzak, I., Evans, R., Ussar, S., Moser, M., Metin, A., Fried, M., Tomlinson, I. et al. (2009). Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat. Med. 15, 306-312.
41. Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R. C., de Pereda, J. M., Ginsberg, M. H. and Calderwood, D. A. (2003). Talin binding to integrin beta tails: a final common step in integrin activation. Science 302, 103-106. (Pubitemid 37210697)
42. Tu, Y., Wu, S., Shi, X., Chen, K. and Wu, C. (2003). Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 113, 37-47. (Pubitemid 36411958)
43. Uhrin, P., Zaujec, J., Breuss, J. M., Olcaydu, D., Chrenek, P., Stockinger, H., Fuertbauer, E., Moser, M., Haiko, P., Fassler, R. et al. (2010). Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood 115, 3997-4005.
44. Ussar, S., Wang, H. V., Linder, S., Fassler, R. and Moser, M. (2006). The Kindlins: subcellular localization and expression during murine development. Exp. Cell Res. 312, 3142-3151.
45. Ussar, S., Moser, M., Widmaier, M., Rognoni, E., Harrer, C., Genzel-Boroviczeny, O. and Fassler, R. (2008). Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet 4, e1000289.
46. Wegener, K. L., Partridge, A. W., Han, J., Pickford, A. R., Liddington, R. C., Ginsberg, M. H. and Campbell, I. D. (2007). Structural basis of integrin activation by talin. Cell 128, 171-182. (Pubitemid 46048890)
47. Zhang, Y., Tu, Y., Gkretsi, V. and Wu, C. (2006). Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration. J. Biol. Chem. 281, 12397-12407.