Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza bunge

Archives of Pharmacal Research

Volumn 35, Issue 3, 2012, Pages 481-486

  Jang, Tae Su ^a   Zhang, Hai Yan ^b   Kim, Geum Jin ^b   Kim, Dong Woo ^c   Min, Byung Sun ^d   Kang, Wonku ^b   Son, Kun Ho ^e   Na, Min Kyun ^b   Lee, Seung Ho ^b  

^a CHA University   (South Korea)

^b Yeungnam University   (South Korea)

^c National Forensic Service   (South Korea)

^d Catholic University of Daegu   (South Korea)

^e Andong National University   (South Korea)

Author keywords

Abietane diterpenoids; Bioassay guided isolation; Fatty acid synthase; Salvia miltiorrhiza Bunge

Indexed keywords

15,16 DIHYDROTANSHINONE I; CERULENIN; CRYPTOTANSHINONE; CYTOTOXIC AGENT; DANSENSPIROKETALLACTONE; DITERPENOID; DOXORUBICIN; EPIGALLOCATECHIN GALLATE; FATTY ACID SYNTHASE INHIBITOR; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE I; TANSHINONE IIA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PLANT ROOT; PROTON NUCLEAR MAGNETIC RESONANCE; SALVIA MILTIORRHIZA; THIN LAYER CHROMATOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL ASSAY; CELL PROLIFERATION; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACID SYNTHESIS INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; HEXANES; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOTS; RATS; SALVIA MILTIORRHIZA; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84862835703     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0311-8     Document Type: Article

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