New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 5, 2012, Pages 552-558

  Xiong, Jing ^a,b   Bai, Li ^b   Fang, Wei ^b   Fu, Jianyang ^b   Fang, Weirong ^b   Cen, Juan ^b   Kong, Yi ^b   Li, Yunman ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Akt phosphorylation; Antiplatelet; Snake venom

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; COLLAGEN; PADGEM PROTEIN; PENW PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; SEROTONIN; SNAKE VENOM; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTITHROMBOTIC ACTIVITY; ARTICLE; BLOOD CLOTTING DISORDER; CARDIOVASCULAR DISEASE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IN VITRO STUDY; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTHROMBIN TIME; RABBIT; RAT; SEROTONIN RELEASE; THROMBIN TIME; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOGENESIS; WESTERN BLOTTING;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD PLATELETS; COLLAGEN; FIBRINOLYTIC AGENTS; MALE; OLIGOPEPTIDES; P-SELECTIN; PHOSPHORYLATION; PLATELET ACTIVATING FACTOR; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDONECARBOXYLIC ACID; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; THROMBOSIS;

EID: 84862823456     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.12.001     Document Type: Article

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