A novel anti-platelet aggregation tripeptide from Agkistrodon acutus venom: Isolation and characterization

Toxicon

Volumn 54, Issue 2, 2009, Pages 103-109

  Kong, Yi ^a   Huo, Jian li ^a   Xu, Wen ^a   Xiong, Jin ^a   Li, Yun man ^a   Wu, Wu tong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Mass spectrometry; NMR; Platelet aggregation; Snake venom; Thrombosis; Tripeptides

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ASPARAGINE; COLLAGEN; FIBRINOGEN; FIBRINOGEN RECEPTOR; PEPTIDE ANTIBODY; PLATELET AGGREGATION TRIPEPTIDE ANTIBODY; PYROGLUTAMIC ACID; SNAKE VENOM; THROMBIN; TRIPEPTIDE DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG; UROKINASE;

AGKISTRODON; AGKISTRODON ACUTUS; AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ANALYSIS; DRUG EFFECT; DRUG ISOLATION; DRUG PROTEIN BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; THROMBOGENESIS; TOXICITY TESTING;

AGKISTRODON; ANIMALS; CHROMATOGRAPHY, ION EXCHANGE; CROTALID VENOMS; FEMALE; FIBRINOGEN; HUMANS; INTEGRIN BETA3; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; OLIGOPEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEIN IIB; RABBITS; THROMBOSIS;

DEINAGKISTRODON ACUTUS; MUS; ORYCTOLAGUS CUNICULUS;

EID: 67349109751     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.03.027     Document Type: Article

References (22)

1. Amininasab M., Elmi M.M., Endlich N., Endlich K., Parekh N., Naderi-Manesh H., Schaller J., Mostafavi H., Sattler M., Sarbolouki M.N., and Muhle-Goll C. Functional and structural characterization of a novel member of the natriuretic family of peptides from the venom of Pseudocerastes persicus. FEBS Letters 557 (2004) 104-108
2. Barbouche R., Marrakchi N., Mansuelle P., Krifi M., Fenouillet E., Rochat H., and el Ayeb M. Novel anti-platelet aggregation polypeptides from Vipera lebetina venom: isolation and characterization. FEBS Letters 392 (1996) 17381
3. Bengmark S., Elmer O., Goransson G., and Zoucas E. In vitro effect of ethanol on ADP and collagen-induced platelet aggregation. Thrombosis and Haemostasis 46 4 (1981) 673-675
4. Berry C.N., Girard D., Lochot S., and Lecoffre C. Antithrombotic actions of argatroban in rat models of venous, mixed and arterial thrombosis, and its effects on the tail transection bleeding time. British Journal of Pharmacology 113 (1994) 1209-1214
5. Cai Z.L., Chen S.M., and Feng W.F. Tris-Tricine-PAGE: a improved separation method of low molecular peptides. Academic Journal of Second Military Medical University 20 9 (1999) 669-670
6. Coelho A.L., de Freitas M.S., Oliveira-Carvalho A.L., Moura-Neto V., Zinqali R.B., and Barja-Fidalgo C. Effects of jarastatin, a novel snake venom disintegrin, on neutrophil migration and actin cytoskeleton dynamics. Experimental Cell Research 251 (1999) 379-387
7. Fitzgerald D.J., Roy L., Catella F., and Fitzgerald G.A. Platelet activation in unstable coronary disease. New England Journal of Medicine 315 (1986) 983
8. Gomes A., and De P. A novel fibrinolytic peptide from the Indian king cobra (Ophiophagus hannah) venom. Biochemical and Biophysical Research Communications 266 (1999) 488-491
9. Gomes V.M., Carvalho A.O., Da Cunha M., Keller M.N., Bloch C., Deolindo P., and Alves E.W. Purification and characterization of a novel peptide with antifungal activity from Bothrops jararaca venom. Toxicon 45 (2005) 817-827
10. Huang T.F. What have snakes taught us about integrins. Cellular and Molecular Life Sciences 54 (1998) 527-540
11. Kang I.C., Chung K.H., Lee S.J., Yun Y., Moon H.M., and Kim D.S. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon Halys Brevicaudus) venom. Thrombosis Research 91 (1998) 65-73
12. Li S.P., Ji H., Cheng X., Li B.X., and Ng T.B. Antithrombotic and thrombolytic activities of Agkisacutacin, a snake venom proteinase, in experimental models. General Pharmacology 35 (2002) 179-187
13. Matsui T., Fujimura Y., and Titani K. Snake venom proteases affecting hemostasis and thrombosis. Biochimica et Biophysica Acta 1477 (2000) 146-156
14. OuYang C., Teng C.M., and Huang T.F. Characterization of snake venom components acting on blood coagulation and platelet function. Toxicon 30 (1992) 945-966
15. Rand M.L., Packham M.A., Kinlough-Rathbone R.L., and Fraser Mustard J. Effects of ethanol on pathways of platelet aggregation in vitro. Thrombosis and Haemostasis 59 3 (1988) 383-387
16. Santosa J.C., Mesquita J.M., Belmiro C.L., da Silveira C.B., Viskov C., Mourier P.A., and Pavão M.S. Isolation and characterization of a heparin with low antithrombin activity from the body of Styela plicata (Chordata-Tunicata). Distinct effects in venous and arterial models of thrombosis. Thrombosis Research 121 2 (2007) 213-223
17. Takagi J. Structural basis for ligand recognition by integrins. Current Opinion in Cell Biology 19 (2007) 557-564
18. Tang Z.Y., Wang Y.Y., Xiao Y.L., Zhao M., and Peng S.Q. Anti-thrombotic activity of PDR, a newly synthesized l-Arg derivative, on three thrombosis models in rats. Thrombosis Research 110 (2003) 127-130
19. Vogel G.M., Meuleman D.G., Bourgondien F.G., and Hobbelen P.M. Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans. Thrombosis Research 54 (1989) 399-410
20. Xie M.L., Lu Q., and Gu Z.L. Effect of quercetin on platelet aggregation induced by oxyradicals. Acta Pharmacologica Sinica 17 4 (1996) 334-336
21. Xu W., Wu S.Y., Li Z.Q., Zhang J.J., and Wu S.G. Purification of a small peptide SV-PP-3 from the venom of Agkistrodon blomhoffii siniticus and its inhibition of platelet aggregation. Academic Journal of First Military Medical University 25 4 (2005) 476-478
22. Yeh C.H., Chang M.C., Peng H.C., and Huang T.F. Pharmacological characterization and antithrombotic effect of agkistin, a platelet glycoprotein Ib antagonist. British Journal of Pharmacology 132 (2001) 843-850