Danazol as first-line therapy for aplastic anemia

Annals of Hematology

Volumn 90, Issue 5, 2011, Pages 523-527

  Jaime Pérez, José Carlos ^a   Colunga Pedraza, Perla R ^a   Gómez Ramírez, Cynthia D ^a   Gutiérrez Aguirre, César H ^a   Cantú Rodríguez, Olga G ^a   Tarín Arzaga, Luz C ^a   Gómez Almaguer, David ^a  

^a HOSPITAL UNIVERSITARIO DR JOSÉ ELEUTERIO GONZÁLEZ   (Mexico)

Author keywords

Androgens; Aplastic anemia; Danazol; HSCT

Indexed keywords

DANAZOL;

ADOLESCENT; ADULT; APLASTIC ANEMIA; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE INCREASE; ERYTHROCYTE TRANSFUSION; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEALTH CARE ACCESS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA MATCHING; HUMAN; INTERMETHOD COMPARISON; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MORTALITY; OBSERVATIONAL STUDY; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; REMISSION; RETROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT DURATION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANDROGENS; ANEMIA, APLASTIC; CHILD; DANAZOL; DEVELOPING COUNTRIES; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LONGITUDINAL STUDIES; MALE; MEXICO; MIDDLE AGED; REMISSION INDUCTION; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 79956134891     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-011-1163-x     Document Type: Article

References (23)

1. Young NS, Kaufman DW (2008) The epidemiology of acquired aplastic anemia. Haematologica 93(4):489-492 (Pubitemid 351536374)
2. Young NS, Calado RT, Scheinberg P (2006) Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 108 (8):2509-2519. doi:10.1182/blood-2006-03-010777
3. Young NS (2002) Acquired aplastic anemia. Ann Intern Med 136 (7):534-546
4. Young NS, Barrett AJ (1995) The treatment of severe acquired aplastic anemia. Blood 85(12):3367-3377
5. Frickhofen N, Rosenfeld SJ (2000) Immunosuppressive treatment of aplastic anemia with antithymocyte globulin and cyclosporine. Semin Hematol 37(1):56-68 (Pubitemid 30080247)
6. Bacigalupo A, Broccia G, Corda G, Arcese W, Carotenuto M, Gallamini A, Locatelli F, Mori PG, Saracco P, Todeschini G et al (1995) Antilymphocyte globulin, cyclosporin, and granulocyte colony-stimulating factor in patients with acquired severe aplastic anemia (SAA): a pilot study of the EBMT SAA Working Party. Blood 85(5):1348-1353
7. Atta EH, Dias DS, Marra VL, de Azevedo AM (2010) Comparison between horse and rabbit antithymocyte globulin as first-line treatment for patients with severe aplastic anemia: a single-center retrospective study. Ann Hematol 89(9):851-859
8. Shahidi NT, Diamond LK (1959) Testosterone-induced remission in aplastic anemia. AMA J Dis Child 98:293-302
9. Locasciulli A, Oneto R, Bacigalupo A, Socie G, Korthof E, Bekassy A, Schrezenmeier H, Passweg J, Fuhrer M (2007) Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 92(1):11-18 (Pubitemid 46232653)
10. Calado RT, Yewdell WT, Wilkerson KL, Regal JA, Kajigaya S, Stratakis CA, Young NS (2009) Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood 114(11):2236-2243
11. Li FP, Alter BP, Nathan DG (1972) The mortality of acquired aplastic anemia in children. Blood 40(2):153-162
12. Madanes AE, Farber M (1982) Danazol. Ann Intern Med 96 (5):625-630 (Pubitemid 12111124)
13. Mori H, Nakagawa M, Itoh N, Wada K, Tamaya T (1990) Danazol suppresses the production of interleukin-1 beta and tumor necrosis factor by human monocytes. Am J Reprod Immunol 24(2):45-50
14. Chuhjo T, Yamazaki H, Omine M, Nakao S (2008) Danazol therapy for aplastic anemia refractory to immunosuppressive therapy. Am J Hematol 83(5):387-389 (Pubitemid 351614752)
15. Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC, Keidan J, Laurie A, Martin A, Mercieca J, Killick SB, Stewart R, Yin JA (2009) Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol 147(1):43-70. doi:10.1111/j.1365-2141.2009.07842.x
16. Camitta BM, Storb R, Thomas ED (1982) Aplastic anemia (first of two parts): pathogenesis, diagnosis, treatment, and prognosis. N Engl J Med 306(11):645-652 (Pubitemid 12192881)
17. Bacigalupo A, Hows J, Gluckman E, Nissen C, Marsh J, Van Lint MT, Congiu M, De Planque MM, Ernst P, McCann S et al (1988) Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party. Br J Haematol 70 (2):177-182
18. Jaime-Perez JC, Ruiz-Arguelles GJ, Gomez-Almaguer D (2005) Haematopoietic stem cell transplantation to treat aplastic anaemia. Expert Opin Biol Ther 5(5):617-626 (Pubitemid 40780546)
19. Ferrer-Argote V R-PC, Hernández-Sánchez M, García-García J, Castellanos-Sinco H, León-González G, Montañó-Figueroa E. (2008) Androgen treatment for acquired aplastic anemia in Mexican adults. Paper presented at the 50th ASH Annual Meeting and Exposition, San Francisco, CA, 6-9 Dec 2008
20. Sanchez-Medal L, Gomez-Leal A, Duarte L, Guadalupe Rico M (1969) Anabolic androgenic steroids in the treatment of acquired aplastic anemia. Blood 34(3):283-300
21. Kojima S, Horibe K, Inaba J, Yoshimi A, Takahashi Y, Kudo K, Kato K, Matsuyama T (2000) Long-term outcome of acquired aplastic anaemia in children: comparison between immunosuppressive therapy and bone marrow transplantation. Br J Haematol 111(1):321-328
22. Gomez-Almaguer D, Jaime-Perez JC, Garza-Rodriguez V, Chapa-Rodriguez A, Tarin-Arzaga L, Herrera-Garza JL, Ruiz-Arguelles GJ, Lopez-Otero A, Gonzalez-Llano O, Rodriguez-Romo L (2009) Subcutaneous alemtuzumab plus cyclosporine for the treatment of aplastic anemia. Ann Hematol 89(3):299-303
23. Bacigalupo A, Chaple M, Hows J, Van Lint MT, McCann S, Milligan D, Chessells J, Goldstone AH, Ottolander J, Van't Veer ET et al (1993) Treatment of aplastic anaemia (AA) with antilymphocyte globulin (ALG) and methylprednisolone (MPred) with or without androgens: a randomized trial from the EBMT SAA working party. Br J Haematol 83(1):145-151