Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways

Life Sciences

Volumn 90, Issue 9-10, 2012, Pages 373-380

  Moon, Eun Yi ^a   Lee, Geun Hee ^a   Lee, Myung Shik ^b   Kim, Hwan Mook ^c   Lee, Jae Wook ^a  

^a Sejong University   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Gachon University   (South Korea)

Author keywords

cAMP; Epac1; Glioblastoma; PDE; PKA; Rap1; Rolipram

Indexed keywords

8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; ADENYLATE CYCLASE ACTIVATOR; BUCLADESINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; ISOBUTYLMETHYLXANTHINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHODIESTERASE IV; RAP1 PROTEIN; ROLIPRAM; THEOPHYLLINE;

ARTICLE; CELL CYCLE; CELL DEATH; CELL DENSITY; CELL SURVIVAL; FLOW CYTOMETRY; GLIOBLASTOMA; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

1-METHYL-3-ISOBUTYLXANTHINE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BRAIN NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; GLIOBLASTOMA; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; ISOQUINOLINES; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; ROLIPRAM; SIGNAL TRANSDUCTION; SULFONAMIDES; TELOMERE-BINDING PROTEINS; THEOPHYLLINE;

EID: 84862808228     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.12.010     Document Type: Article

References (28)

1. F. Block, W. Schmidt, M. Nolden-Koch, and M. Schwarz Rolipram reduces excitotoxic neuronal damage Neuroreport 12 2001 1507 1511 (Pubitemid 32476156)
2. G. Bolger, T. Michaeli, T. Martins, T. St John, B. Steiner, and L. Rodgers A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs Mol Cell Biol 13 1993 6558 6571 (Pubitemid 23292650)
3. J.L. Bos Epac: a new cAMP target and new avenues in cAMP research Nat Rev Mol Cell Biol 4 2003 733 738 (Pubitemid 37082188)
4. J.A. Brown, S.M. Gianino, and D.H. Gutmann Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity J Neurosci 30 2010 5579 5589
5. A.O. Caggiano, and R.P. Kraig Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production J Neurochem 72 1999 565 575 (Pubitemid 29055218)
6. H.J. Cho, S.A. Choi, C.G. Kim, T.S. Jung, J.H. Hong, and M.H. Rhee Spinach saponin-enriched fraction inhibits platelet aggregation in cAMP- and cGMP-dependent manner by decreasing TXA2 production and blood coagulation Biomol Ther 19 2011 218 223
7. J. de Rooij, F.J. Zwartkruis, M.H. Verheijen, R.H. Cool, S.M. Nijman, and A. Wittinghofer Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP Nature 396 1998 474 477 (Pubitemid 28553318)
8. F. Denizot, and R. Lang Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability J Immunol Methods 89 1986 271 277 (Pubitemid 16080782)
9. J.M. Enserink, A.E. Christensen, J. de Rooij, M. van Triest, F. Schwede, and H.G. Genieser A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK Nat Cell Biol 4 2002 901 906 (Pubitemid 35331366)
10. P. Goldhoff, N.M. Warrington, D.D. Limbrick Jr., A. Hope, B.M. Woerner, and E. Jackson Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression Clin Cancer Res 14 2008 7717 7725
11. A. Hatzelmann, and C. Schudt Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro J Pharmacol Exp Ther 297 2001 267 279 (Pubitemid 32242587)
12. S. Kesari, N. Ramakrishna, C. Sauvageot, C.D. Stiles, and P.Y. Wen Targeted molecular therapy of malignant gliomas Curr Neurol Neurosci Rep 5 2005 186 197 (Pubitemid 40873034)
13. S. Kesari, N. Ramakrishna, C. Sauvageot, C.D. Stiles, and P.Y. Wen Targeted molecular therapy of malignant gliomas Curr Oncol Rep 8 2006 58 70 (Pubitemid 43154265)
14. D.H. Kim, and A. Lerner Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia Blood 92 1998 2484 2494 (Pubitemid 28452992)
15. E.C. Lee, Y.S. Lee, N. Park, K.S. So, Y.J. Chun, and M.Y. Kim Ceramide induces apoptosis and growth arrest of human glioblastoma cells by inhibiting Akt signaling pathways Biomol Ther 19 2011 21 26
16. R. Lee, S. Wolda, E. Moon, J. Esselstyn, C. Hertel, and A. Lerner PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP Cell Signal 14 2002 277 284 (Pubitemid 34102457)
17. T. Miki, M. Taira, S. Hockman, F. Shimada, J. Lieman, and M. Napolitano Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family Genomics 36 1996 476 485 (Pubitemid 26321970)
18. G. Minniti, R. Muni, G. Lanzetta, P. Marchetti, and R.M. Enrici Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents Anticancer Res 29 2009 5171 5184
19. E.Y. Moon, J.H. Lee, J.W. Lee, J.H. Song, and S. Pyo ROS/Epac1-mediated Rap1/NF-kappaB activation is required for the expression of BAFF in Raw264.7 murine macrophages Cell Signal 23 2011 1479 1488
20. E.Y. Moon, and A. Lerner PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A Blood 101 2003 4122 4130 (Pubitemid 36857894)
21. E.Y. Moon, S.Y. Oh, G.H. Han, C.S. Lee, and S.K. Park Epac1-mediated Rap1 activation is not required for the production of nitric oxide in BV2, murine microglial cells J Neurosci Res 81 2005 38 44
22. Y. Nakamura, Q.S. Si, and K. Kataoka Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide Neurosci Res 35 1999 95 100 (Pubitemid 29518400)
23. X.D. Ren, W.B. Kiosses, and M.A. Schwartz Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton EMBO J 18 1999 578 585 (Pubitemid 29057242)
24. W.A. Sands, and T.M. Palmer Regulating gene transcription in response to cyclic AMP elevation Cell Signal 20 2008 460 466
25. S. Tiwari, K. Felekkis, E.Y. Moon, A. Flies, D.H. Sherr, and A. Lerner Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis Blood 103 2004 2661 2667 (Pubitemid 38393022)
26. N.M. Warrington, S.M. Gianino, E. Jackson, P. Goldhoff, J.R. Garbow, and D. Piwnica-Worms Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1 Cancer Res 70 2010 5717 5727
27. L. Yang, E. Jackson, B.M. Woerner, A. Perry, D. Piwnica-Worms, and J.B. Rubin Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo Cancer Res 67 2007 651 658 (Pubitemid 46192204)
28. B. Zhang, L. Yang, Y. Konishi, N. Maeda, M. Sakanaka, and J. Tanaka Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: comparison with other types of cAMP-elevating agents Neuropharmacology 42 2002 262 269 (Pubitemid 34137030)