Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF

Brain Research

Volumn 1449, Issue , 2012, Pages 69-82

  Wang, Linhui ^a   Lin, Fang ^a   Wang, Jin ^a   Wu, Junchao ^a   Han, Rong ^a   Zhu, Lujia ^a   Difiglia, Marian ^b   Qin, Zhenghong ^a  

^a SOOCHOW UNIVERSITY   (China)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Astrocytes; Brain derived neurotrophic factor; Huntingtin; Huntington's disease; Secretion

Indexed keywords

ADENOVIRUS VECTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CLATHRIN; HUNTINGTIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GOLGI COMPLEX; HUNTINGTON CHOREA; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; WILD TYPE;

ANIMALS; ASTROCYTES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; CLATHRIN; NERVE TISSUE PROTEINS; NEURITES; NEURONS; NUCLEAR PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84862808094     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.01.077     Document Type: Article

References (65)

1. C.A. Altar, N. Cai, T. Bliven, M. Juhasz, J.M. Conner, A.L. Acheson, R.M. Lindsay, and S.J. Wiegand Anterograde transport of brain-derived neurotrophic factor and its role in the brain Nature 389 1997 856 860
2. S.J. Baloyannis, V. Costa, and D. Michmizos Mitochondrial alterations in Alzheimer's disease Am. J. Alzheimers Dis. Other Demen. 19 2004 89 93
3. P.E. Batchelor, G.T. Liberatore, J.Y. Wong, M.J. Porritt, F. Frerichs, G.A. Donnan, and D.W. Howells Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor J. Neurosci. 19 1999 1708 1716
4. M. Bergami, S. Santi, E. Formaggio, C. Cagnoli, C. Verderio, R. Blum, B. Berninger, M. Matteoli, and M. Canossa Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes J. Cell Biol. 183 2008 213 221
5. D.K. Binder, and H.E. Scharfman Brain-derived neurotrophic factor Growth Factors 22 2004 123 131
6. J. Block-Galarza, K.O. Chase, E. Sapp, K.T. Vaughn, R.B. Vallee, M. DiFiglia, and N. Aronin Fast transport and retrograde movement of huntingtin and HAP 1 in axons Neuroreport 8 1997 2247 2251
7. M. Borrell-Pages, J.M. Canals, F.P. Cordelieres, J.A. Parker, J.R. Pineda, G. Grange, E.A. Bryson, M. Guillermier, E. Hirsch, P. Hantraye, M.E. Cheetham, C. Neri, J. Alberch, E. Brouillet, F. Saudou, and S. Humbert Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase J. Clin. Invest. 116 2006 1410 1424
8. J. Bradford, J.Y. Shin, M. Roberts, C.E. Wang, X.J. Li, and S. Li Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms Proc. Natl. Acad. Sci. U. S. A. 106 2009 22480 22485
9. G.J. Brewer, J.R. Torricelli, E.K. Evege, and P.J. Price Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination J. Neurosci. Res. 35 1993 567 576
10. J.M. Canals, J.R. Pineda, J.F. Torres-Peraza, M. Bosch, R. Martin-Ibanez, M.T. Munoz, G. Mengod, P. Ernfors, and J. Alberch Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease J. Neurosci. 24 2004 7727 7739
11. S. Carreno, A.E. Engqvist-Goldstein, C.X. Zhang, K.L. McDonald, and D.G. Drubin Actin dynamics coupled to clathrin-coated vesicle formation at the trans-Golgi network J. Cell Biol. 165 2004 781 788
12. J.P. Caviston, J.L. Ross, S.M. Antony, M. Tokito, and E.L. Holzbaur Huntingtin facilitates dynein/dynactin-mediated vesicle transport Proc. Natl. Acad. Sci. U. S. A. 104 2007 10045 10050
13. S. Ceccatelli, P. Ernfors, M.J. Villar, H. Persson, and T. Hokfelt Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment Proc. Natl. Acad. Sci. U. S. A. 88 1991 10352 10356
14. M.E. Cheetham, B.H. Anderton, and A.P. Jackson Inhibition of hsc70-catalysed clathrin uncoating by HSJ1 proteins Biochem. J. 319 1996 103 108
15. S.Y. Chou, J.Y. Weng, H.L. Lai, F. Liao, S.H. Sun, P.H. Tu, D.W. Dickson, and Y. Chern Expanded polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes J. Neurosci. 28 2008 3277 3290
16. D. del Toro, J.M. Canals, S. Ginés, M. Kojima, G. Egea, and J. Alberch Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism J. Neurosci. 26 2006 12748 12757
17. D. del Toro, J. Alberch, F. Lázaro-Diéguez, R. Martín-Ibáñez, X. Xifró, G. Egea, and J.M. Canals Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus Mol. Biol. Cell 20 2009 1478 1492
18. M. DiFiglia, E. Sapp, K. Chase, C. Schwarz, A. Meloni, C. Young, E. Martin, J.P. Vonsattel, R. Carraway, S.A. Reeves, F.M. Boyce, and N. Aronin Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons Neuron 14 1995 1075 1081
19. M. DiFiglia, E. Sapp, K.O. Chase, S.W. Davies, G.P. Bates, J.P. Vonsattel, and N. Aronin Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain Science 277 1997 1990 1993
20. G. Egea, F. Lazaro-Dieguez, and M. Vilella Actin dynamics at the Golgi complex in mammalian cells Curr. Opin. Cell Biol. 18 2006 168 178
21. I. Ferrer, E. Goutan, C. Marin, M.J. Rey, and T. Ritalta Brain-derived neurotrophic factor in Huntington disease Brain Res. 866 2000 257 261
22. J. Frisen, V.M. Verge, K. Fried, M. Risling, H. Persson, J. Trotter, T. Hokfelt, and D. Lindholm Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems Proc. Natl. Acad. Sci. U. S. A. 90 1993 4971 4975
23. Y. Fujita, E. Ohama, M. Takatama, S. Al-Sarraj, and K. Okamoto Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease Acta Neuropathol. 112 2006 261 265
24. L.R. Gauthier, B.C. Charrin, M. Borrell-Pages, J.P. Dompierre, H. Rangone, F.P. Cordelieres, J. De Mey, M.E. MacDonald, V. Lessmann, S. Humbert, and F. Saudou Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules Cell 118 2004 127 138
25. P.A. Gleeson, J.G. Lock, M.R. Luke, and J.L. Stow Domains of the TGN: coats, tethers and G proteins Traffic 5 2004 315 326
26. S. Gunawardena, and L.S. Goldstein Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease J. Neurobiol. 58 2004 258 271
27. W. Haubensak, F. Narz, R. Heumann, and V. Lessmann BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons J. Cell Sci. 111 1998 1483 1493
28. P. Hilditch-Maguire, F. Trettel, L.A. Passani, A. Auerbach, F. Persichetti, and M.E. MacDonald Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles Hum. Mol. Genet. 9 2000 2789 2797
29. F. Kepes, A. Rambourg, and B. Satiat-Jeunemaitre Morphodynamics of the secretory pathway Int. Rev. Cytol. 242 2005 55 120
30. M. Kojima, N. Takei, T. Numakawa, Y. Ishikawa, S. Suzuki, T. Matsumoto, R. Katoh-Semba, H. Nawa, and H. Hatanaka Biological characterization and optical imaging of brain-derived neurotrophic factor-green fluorescent protein suggest an activity-dependent local release of brain-derived neurotrophic factor in neurites of cultured hippocampal neurons J. Neurosci. Res. 64 2001 1 10
31. X.J. Li, and S.H. Li HAP1 and intracellular trafficking Trends Pharmacol. Sci. 26 2005 1 3
32. J.C. Liévens, B. Woodman, A. Mahal, O. Spasic-Boscovic, D. Samuel, L. Kerkerian-Le Goff, and G.P. Bates Impaired glutamate uptake in the R6 Huntington's disease transgenic mice Neurobiol. Dis. 8 2001 807 821
33. J.C. Liévens, T. Rival, M. Iche, H. Chneiweiss, and S. Birman Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila Hum. Mol. Genet. 14 2005 713 724
34. R.B. Maccioni, J.P. Munoz, and L. Barbeito The molecular bases of Alzheimer's disease and other neurodegenerative disorders Arch. Med. Res. 32 2001 367 381
35. J.R. McGuire, J. Rong, S.H. Li, and X.J. Li Interaction of Huntingtin associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons J. Biol. Chem. 281 2005 3552 3559
36. K. Nakajima, Y. Kikuchi, E. Ikoma, S. Honda, M. Ishikawa, Y. Liu, and S. Kohsaka Neurotrophins regulate the function of cultured microglia Glia 24 1998 272 289
37. J.M. Oliveira, and J. Goncalves In situ mitochondrial Ca2 + buffering differences of intact neurons and astrocytes from cortex and striatum J. Biol. Chem. 284 2009 5010 5020
38. E. Perez-Navarro, J. Alberch, I. Neveu, and E. Arenas Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivo Neuroscience 91 1999 1257 1264
39. E. Perez-Navarro, A.M. Canudas, P. Akerund, J. Alberch, and E. Arenas Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease J. Neurochem. 75 2000 2190 2199
40. Z.H. Qin, Y. Wang, E. Sapp, B. Cuiffo, E. Wanker, M.R. Hayden, K.B. Kegel, N. Aronin, and M. DiFiglia Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction J. Neurosci. 24 2004 269 281
41. A. Reiner, R.L. Albin, K.D. Anderson, C.J. D'Amato, J.B. Penney, and A.B. Young Differential loss of striatal projection neurons in Huntington disease Proc. Natl. Acad. Sci. U. S. A. 85 1988 5733 5737
42. J.L. Ridet, S.K. Malhotra, A. Privat, and F.H. Gage Reactive astrocytes: cellular and molecular cues to biological function Trends Neurosci. 20 1997 570 577
43. J.D. Roback, H.N. Marsh, M. Downen, H.C. Palfrey, and B.H. Wainer BDNF-activated signal transduction in rat cortical glial cells Eur. J. Neurosci. 7 1995 849 862
44. H.D. Rosas, W.J. Koroshetz, Y.I. Chen, C. Skeuse, M. Vangel, M.E. Cudkowicz, K. Caplan, K. Marek, L.J. Seidman, N. Makris, B.G. Jenkins, and J.M. Goldstein Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis Neurology 60 2003 1615 1620
45. H.D. Rosas, N.D. Hevelone, A.K. Zaleta, D.N. Greve, D.H. Salat, and B. Fischl Regional cortical thinning in preclinical Huntington disease and its relationship to cognition Neurology 65 2005 745 747
46. H.D. Rosas, D.H. Salat, S.Y. Lee, A.K. Zaleta, V. Pappu, B. Fischl, D. Greve, N. Hevelone, and S.M. Hersch Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity Brain 131 2008 1057 1068
47. J.S. Rudge, Y. Li, E.M. Pasnikowski, K. Mattsson, L. Pan, G.D. Yancopoulos, S.J. Wiegand, R.M. Lindsay, and N.Y. Ip Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes Eur. J. Neurosci. 6 1994 693 705
48. J.K. Ryu, S.U. Kim, and J.G. McLarnon Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease Exp. Neurol. 187 2004 150 159
49. J.Y. Shin, Z.H. Fang, Z.X. Yu, C.E. Wang, S.H. Li, and X.J. Li Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity J. Cell Biol. 171 2005 1001 1012
50. K.A. Sieradzan, A.O. Mechan, L. Jones, E.E. Wanker, N. Nukina, and D.M. Mann Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein Exp. Neurol. 156 1999 92 99
51. R.R. Singaraja, S. Hadano, M. Metzler, S. Givan, C.L. Wellington, S. Warby, A. Yanai, C.A. Gutekunst, B.R. Leavitt, H. Yi, K. Fichter, L. Gan, K. McCutcheon, V. Chopra, J. Michel, S.M. Hersch, J.E. Ikeda, and M.R. Hayden HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis Hum. Mol. Genet. 11 2002 2815 2828
52. A. Stieber, Y. Chen, S. Weil, Z. Mourelatos, J.O. Gonatas, K. Okamoto, and N.K. Gonatas The fragmented neuronal Golgi apparatus in amyotrophic lateral sclerosis includes the trans-Golgi-network: functional implications Acta Neuropathol. 95 1998 245 253
53. The Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell 72 1993 971 983
54. Y. Tokita, H. Keino, F. Matsui, S. Aono, H. Ishiguro, S. Higashiyama, and A. Oohira Regulation of neuregulin expression in the injured rat brain and cultured astrocytes J. Neurosci. 21 2001 1257 1264
55. M. Valenza, V. Leoni, J.M. Karasinska, L. Petricca, J. Fan, J. Carroll, M.A. Pouladi, E. Fossale, H.P. Nguyen, O. Riess, M. MacDonald, C. Wellington, S. DiDonato, M. Hayden, and E. Cattaneo Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes J. Neurosci. 30 2010 10844 10850
56. M. Vila, V. Jackson-Lewis, C. Guegan, D.C. Wu, P. Teismann, D.K. Choi, K. Tieu, and S. Przedborski The role of glial cells in Parkinson's disease Curr. Opin. Neurol. 14 2001 483 489
57. A. Walker, C. Ward, T.A. Sheldrake, I. Dransfield, A.G. Rossi, J.G. Pryde, and C. Haslett Golgi fragmentation during Fas-mediated apoptosis is associated with the rapid loss of GM130 Biochem. Biophys. Res. Commun. 316 2004 6 11
58. L.H. Wang, F. Lin, J.C. Wu, and Z.H. Qin High efficiency adenovirus-mediated expression of truncated N-terminal huntingtin fragment (htt552) in primary rat astrocytes Acta Biochim. Biophys. Sin. 41 2009 325 334
59. C.L. Wellington, L.M. Ellerby, A.S. Hackam, R.L. Margolis, M.A. Trifiro, R. Singaraja, K. McCutcheon, G.S. Salvesen, S.S. Propp, M. Bromm, K.J. Rowland, T. Zhang, D. Rasper, S. Roy, N. Thornberry, L. Pinsky, A. Kakizuka, C.A. Ross, D.W. Nicholson, D.E. Bredesen, and M.R. Hayden Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract J. Biol. Chem. 273 1998 9158 9167
60. C.L. Wellington, L.M. Ellerby, C.A. Gutekunst, D. Rogers, S. Warby, R.K. Graham, O. Loubser, J. van Raamsdonk, R. Singaraja, Y.Z. Yang, J. Gafni, D. Bredesen, S.M. Hersch, B.R. Leavitt, S. Roy, D.W. Nicholson, and M.R. Hayden Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease J. Neurosci. 22 2002 7862 7872
61. L.L. Wu, Y. Fan, S. Li, X.J. Li, and X.F. Zhou Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release J. Biol. Chem. 285 2010 5614 5623
62. Z. Zhang, and M. Chopp Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia Trends Cardiovasc. Med. 12 2002 62 66
63. C. Zuccato, and E. Cattaneo Role of brain-derived neurotrophic factor in Huntington's disease Prog. Neurobiol. 81 2007 294 330
64. C. Zuccato, A. Ciammola, D. Rigamonti, B.R. Leavitt, D. Goffredo, L. Conti, M.E. MacDonald, R.M. Friedlander, V. Silani, M.R. Hayden, T. Timmusk, S. Sipione, and E. Cattaneo Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease Science 293 2001 493 498
65. C. Zuccato, M. Marullo, P. Conforti, M.E. MacDonald, M. Tartari, and E. Cattaneo Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease Brain Pathol. 182 2008 225 238