The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification

Genes Chromosomes and Cancer

Volumn 51, Issue 6, 2012, Pages 569-578

  Italiano, Antoine ^a,b   Thomas, Rachael ^c   Breen, Matthew ^c,d   Zhang, Lei ^a   Crago, Aimee M ^a   Singer, Samuel ^a   Khanin, Raya ^a   Maki, Robert G ^e   Mihailovic, Aleksandra ^f   Hafner, Markus ^f   Tuschl, Tom ^f   Antonescu, Cristina R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b INSTITUT BERGONIÉ   (France)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MIR 17 92; MYC PROTEIN; SMALL NUCLEAR RNA; THROMBOSPONDIN 1; UNCLASSIFIED DRUG;

ADULT; AGED; ANGIOSARCOMA; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE SEQUENCE; HUMAN; MALE; METASTASIS; MICROARRAY ANALYSIS; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOMA; UPREGULATION; VASCULAR TUMOR; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; COMPARATIVE GENOMIC HYBRIDIZATION; DNA-BINDING PROTEINS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HEMANGIOSARCOMA; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICRORNAS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-MYC; SEQUENCE ANALYSIS, RNA; THROMBOSPONDIN 1; TRANSCRIPTION FACTORS; VASCULAR NEOPLASMS;

EID: 84862805832     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.21943     Document Type: Article

References (31)

1. Adepoju O, Wong A, Kitajewski A, Tong K, Boscolo E, Bischoff J, Kitajewski J, Wu JK. 2011. Expression of HES and HEY genes in infantile hemangiomas. Vasc Cell 3: 19.
2. Adhikary S, Eilers M. 2005. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 6: 635-645.
3. Albihn A, Johnsen JI, Henriksson MA. 2010. MYC in oncogenesis and as a target for cancer therapies. Adv Cancer Res 107: 163-224.
4. Anders S, Huber W. 2010. Differential expression analysis for sequence count data. Genome Biol 11: R106.
5. Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Edelman M, Rosenberg AE, Nielsen GP, Dal Cin P, Fletcher CD. 2010. EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer 49: 1114-1124.
6. Baker LH, Rowinsky EK, Mendelson D, Humerickhouse RA, Knight RA, Qian J, Carr RA, Gordon GB, Demetri GD. 2008. Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma. J Clin Oncol 26: 5583-5588.
7. Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, White EL, Davis AC, Ihle JN, Cleveland JL. 2002. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev 16: 2530-2543.
8. Bradham DM, Igarashi A, Potter RL, Grotendorst GR. 1991. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 114: 1285-1294.
9. Calicchio ML, Collins T, Kozakewich HP. 2009. Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling. Am J Pathol 174: 1638-1649.
10. Dang CV, Kim JW, Gao P, Yustein J. 2008. The interplay between MYC and HIF in cancer. Nat Rev Cancer 8: 51-56.
11. Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, Thomas-Tikhonenko A. 2006. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 38: 1060-1065.
12. Dews M, Fox JL, Hultine S, Sundaram P, Wang W, Liu YY, Furth E, Enders GH, El-Deiry W, Schelter JM, Cleary MA, Thomas-Tikhonenko A. 2010. The myc-miR-17-92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res 70: 8233-8246.
13. Fayette J, Martin E, Piperno-Neumann S, Le Cesne A, Robert C, Bonvalot S, Ranchere D, Pouillart P, Coindre JM, Blay JY. 2007. Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol 18: 2030-2036.
14. Fletcher CD, Unni K, Mertens F. 2002. World Health Organization Classification of Tumours Pathology and Genetics of Tumours of Soft Tissue and Bone, Lyon: IARC Press.
15. Gordan JD, Thompson CB, Simon MC. 2007. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 12: 108-113.
16. Guo T, Chang NE, Singer S, Maki RG, Antonescu CR. 2011. Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. Genes Chromosomes Cancer 50: 25-33.
17. Hadj-Hamou NS, Ugolin N, Ory C, Britzen-Laurent N, Sastre-Garau X, Chevillard S, Malfoy B. 2011. A transcriptome signature distinguished sporadic from postradiotherapy radiation-induced sarcomas. Carcinogenesis 32: 929-934.
18. Hafner M, Renwick N, Pena J, Mihailovic A, Tuschl T. 2010. Barcoded cDNA libraries for miRNA profiling by next-generation sequencing. In: Hartmann RK, Bindereif A, Schon A, Weshof A, editors. Handbook of RNA Biochemistry, 2nd ed. Wennheim, Germany: Wiley-VCHVerlag GmH.
19. Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, Takata S, Kobayashi K, Okada Y. 2002. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J 16: 219-221.
20. Kretzner L, Blackwood EM, Eisenman RN. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature 359: 426-429.
21. Manner J, Radlwimmer B, Hohenberger P, Mossinger K, Kuffer S, Sauer C, Belharazem D, Zettl A, Coindre JM, Hallermann C, Hartmann JT, Katenkamp D, Katenkamp K, Schoffski P, Sciot R, Wozniak A, Lichter P, Marx A, Strobel P. 2010. MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol 176: 34-39.
22. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. 2005. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435: 839-843.
23. Potikyan G, Savene RO, Gaulden JM, France KA, Zhou Z, Kleinerman ES, Lessnick SL, Denny CT. 2007. EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins. Cancer Res 67: 6675-6684.
24. Ranganathan P, Weaver KL, Capobianco AJ. 2011. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 11: 338-351.
25. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P. 2007. An E2F/miR-20a autoregulatory feedback loop. J Biol Chem 282: 2135-2143.
26. Taraboletti G, Benelli R, Borsotti P, Rusnati M, Presta M, Giavazzi R, Ruco L, Albini A. 1999. Thrombospondin-1 inhibits Kaposi's sarcoma (KS) cell and HIV-1 Tat-induced angiogenesis and is poorly expressed in KS lesions. J Pathol 188: 76-81.
27. Thomas R, Seiser EL, Motsinger-Reif A, Borst L, Valli VE, Kelley K, Suter SE, Argyle D, Burgess K, Bell J, Lindblad-Toh K, Modiano JF, Breen M. 2011. Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas. Leuk Lymphoma 52: 1321-1335.
28. Ugras S, Brill E, Jacobsen A, Hafner M, Socci ND, Decarolis PL, Khanin R, O'Connor R, Mihailovic A, Taylor BS, Sheridan R, Gimble JM, Viale A, Crago A, Antonescu CR, Sander C, Tuschl T, Singer S. 2011. Small RNA sequencing and functional characterization reveals microRNA-143 tumor suppressor activity in liposarcoma. Cancer Res 71: 5659-5669.
29. Woods K, Thomson JM, Hammond SM. 2007. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem 282: 2130-2134.
30. Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. 2000. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 26: 484-489.
31. Wu JK, Adepoju O, De Silva D, Baribault K, Boscolo E, Bischoff J, Kitajewski J. 2010. A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma. Angiogenesis 13: 15-23.