Expression of HES and HEY genes in infantile hemangiomas

Vascular Cell

Volumn 3, Issue , 2011, Pages

  Adepoju, Omotinuwe ^a   Wong, Alvin ^a   Kitajewski, Alex ^a   Tong, Karen ^a   Boscolo, Elisa ^b   Bischoff, Joyce ^b   Kitajewski, Jan ^a   Wu, June K ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

hemangioma; hemangioma stem cells; HES HEY transcription factors; Notch receptors; Notch signaling

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CD31 ANTIGEN; GAMMA SECRETASE INHIBITOR; NOTCH RECEPTOR; NOTCH3 RECEPTOR; THY 1 ANTIGEN; TRANSCRIPTION FACTOR HES; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HEY; TRANSCRIPTION FACTOR HEY 1; TRANSCRIPTION FACTOR HEYL; UNCLASSIFIED DRUG;

ARTICLE; CANCER STEM CELL; CAPILLARY HEMANGIOMA; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NOTCH SIGNALING; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84863229873     PISSN: None     EISSN: 2045824X     Source Type: Journal    
DOI: 10.1186/2045-824X-3-19     Document Type: Article

References (35)

1. Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas, April 7-9, 2005, Bethesda, Maryland, USA. Frieden IJ, Haggstrom AN, Drolet BA, Mancini AJ, Friedlander SF, Boon L, Chamlin SL, Baselga E, Garzon MC, Nopper AJ, et al. Pediatr Dermatol 2005 22 5 383 406 10.1111/j.1525-1470.2005.00102.x 16190987 (Pubitemid 43960991)
2. Vascular anomalies. Mulliken JB, Fishman SJ, Burrows PE, Curr Probl Surg 2000 37 8 517 584 10.1016/S0011-3840(00)80013-1 10955029
3. Notch signaling: cell fate control and signal integration in development. Artavanis-Tsakonas S, Rand MD, Lake RJ, Science 1999 284 5415 770 776 10.1126/science.284.5415.770 10221902 (Pubitemid 29291335)
4. Notch signaling in vascular morphogenesis. Alva JA, Iruela-Arispe ML, Curr Opin Hematol 2004 11 4 278 283 10.1097/01.moh.0000130309.44976.ad 15314528 (Pubitemid 39120957)
5. Notch signaling in vascular development. Iso T, Hamamori Y, Kedes L, Arterioscler Thromb Vasc Biol 2003 23 4 543 553 10.1161/01.ATV.0000060892.81529. 8F 12615665 (Pubitemid 36438065)
6. The role of notch in modeling and maintaining the vasculature. Karsan A, Can J Physiol Pharmacol 2005 83 1 14 23 10.1139/y04-125 15759046 (Pubitemid 40754771)
7. Arterial-venous endothelial cell fate is related to vascular endothelial growth factor and Notch status during human bone mesenchymal stem cell differentiation. Zhang G, Zhou J, Fan Q, Zheng Z, Zhang F, Liu X, Hu S, FEBS Lett 2008 582 19 2957 2964 10.1016/j.febslet.2008.07.031 18671974
8. Notch function in the vasculature: insights from zebrafish, mouse and man. Shawber CJ, Kitajewski J, Bioessays 2004 26 3 225 234 10.1002/bies.20004 14988924 (Pubitemid 38325664)
9. A homolog of Drosophila Notch expressed during mammalian development. Weinmaster G, Roberts VJ, Lemke G, Development 1991 113 1 199 205 1764995
10. Notch2: a second mammalian Notch gene. Weinmaster G, Roberts VJ, Lemke G, Development 1992 116 4 931 941 1295745 (Pubitemid 23042434)
11. The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Lardelli M, Dahlstrand J, Lendahl U, Mech Dev 1994 46 2 123 136 10.1016/0925-4773(94)90081-7 7918097 (Pubitemid 24179069)
12. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Uyttendaele H, Marazzi G, Wu G, Yan Q, Sassoon D, Kitajewski J, Development 1996 122 7 2251 2259 8681805 (Pubitemid 26235824)
13. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Gallahan D, Callahan R, Oncogene 1997 14 16 1883 1890 10.1038/sj.onc.1201035 9150355 (Pubitemid 27217801)
14. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Bettenhausen B, Hrabe de Angelis M, Simon D, Guenet JL, Gossler A, Development 1995 121 8 2407 2418 7671806
15. Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Dunwoodie SL, Henrique D, Harrison SM, Beddington RS, Development 1997 124 16 3065 3076 9272948 (Pubitemid 27387084)
16. Dll4, a novel Notch ligand expressed in arterial endothelium. Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL, Genes Dev 2000 14 11 1313 1318 10837024 (Pubitemid 30397075)
17. Jagged: a mammalian ligand that activates Notch1. Lindsell CE, Shawber CJ, Boulter J, Weinmaster G, Cell 1995 80 6 909 917 10.1016/0092-8674(95)90294-5 7697721
18. Jagged2: a serrate-like gene expressed during rat embryogenesis. Shawber C, Boulter J, Lindsell CE, Weinmaster G, Dev Biol 1996 180 1 370 376 10.1006/dbio.1996.0310 8948600 (Pubitemid 26426184)
19. A Potential Role for Notch Signaling in the Pathogenesis and Regulation of Hemangiomas. Wu JK, Kitajewski JK, J Craniofac Surg 2009
20. A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma. Wu JK, Adepoju O, De Silva D, Baribault K, Boscolo E, Bischoff J, Kitajewski J, Angiogenesis 2010 13 1 15 23 10.1007/s10456-009-9161-5 20069356
21. Delta-Notch - and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Fischer A, Gessler M, Nucleic Acids Res 2007 35 14 4583 4596 10.1093/nar/gkm477 17586813 (Pubitemid 47250333)
22. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. Khan ZA, Boscolo E, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J, J Clin Invest 2008 118 2592 2599 18535669 (Pubitemid 351949786)
23. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. Katoh M, Int J Oncol 2007 31 2 461 466 17611704
24. Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Leimeister C, Externbrink A, Klamt B, Gessler M, Mech Dev 1999 85 1-2 173 177 10.1016/S0925-4773(99)00080-5 10415358 (Pubitemid 29343761)
25. HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Nakagawa O, Nakagawa M, Richardson JA, Olson EN, Srivastava D, Dev Biol 1999 216 1 72 84 10.1006/dbio.1999.9454 10588864
26. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Real PJ, Tosello V, Palomero T, Castillo M, Hernando E, de Stanchina E, Sulis ML, Barnes K, Sawai C, Homminga I, et al. Nat Med 2009 15 1 50 58 10.1038/nm.1900 19098907
27. Notch signaling in the vasculature. Gridley T, Curr Top Dev Biol 2010 92 277 309 20816399
28. HES and HERP families: multiple effectors of the Notch signaling pathway. Iso T, Kedes L, Hamamori Y, J Cell Physiol 2003 194 3 237 255 10.1002/jcp.10208 12548545 (Pubitemid 36176887)
29. Hey bHLH factors in cardiovascular development. Wiese C, Heisig J, Gessler M, Pediatr Cardiol 2009 31 3 363 370 20033145
30. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, et al. Nature 2007 445 7129 776 780 10.1038/nature05571 17259973 (Pubitemid 46279716)
31. Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Takeshita K, Satoh M, Ii M, Silver M, Limbourg FP, Mukai Y, Rikitake Y, Radtke F, Gridley T, Losordo DW, Liao JK, Circ Res 2007 100 1 70 78 10.1161/01.RES.0000254788.47304.6e 17158336 (Pubitemid 46066775)
32. Notch pathway modulation on bone marrow-derived vascular precursor cells regulates their angiogenic and wound healing potential. Caiado F, Real C, Carvalho T, Dias S, PLoS ONE 2008 3 11 3752 10.1371/journal.pone.0003752 19015735
33. Involvement of notch signaling in wound healing. Chigurupati S, Arumugam TV, Son TG, Lathia JD, Jameel S, Mughal MR, Tang SC, Jo DG, Camandola S, Giunta M, et al. PLoS ONE 2007 2 11 1167 10.1371/journal.pone.0001167 18000539 (Pubitemid 351637963)
34. Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H, Delmas V, Kageyama R, Beermann F, Larue L, Nishikawa S, J Cell Biol 2006 173 3 333 339 10.1083/jcb.200509084 16651378
35. JAGGED1 Signaling Regulates Hemangioma Stem Cell-to-Pericyte/Vascular Smooth Muscle Cell Differentiation. Boscolo E, Stewart CL, Greenberger S, Wu JK, Durham JT, Herman IM, Mulliken JB, Kitajewski J, Bischoff J, Arterioscler Thromb Vasc Biol 2011