MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema

American Journal of Pathology

Volumn 176, Issue 1, 2010, Pages 34-39

  Manner, Johanna ^a   Radlwimmer, Bernhard ^c   Hohenberger, Peter ^b   Mössinger, Katharina ^a   Küffer, Stefan ^a   Sauer, Christian ^a   Belharazem, Djeda ^a   Zettl, Andreas ^d   Coindre, Jean Michel ^e   Hallermann, Christian ^f   Hartmann, Jörg Thomas ^g   Katenkamp, Detlef ^h   Katenkamp, Kathrin ^h   Schöffski, Patrick ⁱ   Sciot, Raf ^j   Wozniak, Agnieszka ⁱ   Lichter, Peter ^c   Marx, Alexander ^a   Ströbel, Philipp ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d Pathology Viollier   (Switzerland)

^e INSERM   (France)

^f Fachklinik Hornheide   (Germany)

^g UNIVERSITY OF TÜBINGEN   (Germany)

^h FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

ⁱ UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^j Department of Intensive Care University Hospital   (Belgium)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN;

ADULT; AGED; ANGIOSARCOMA; ARTICLE; BREAST CARCINOMA; CANCER RADIOTHERAPY; CELL STRUCTURE; CHROMOSOME 10P; CHROMOSOME 5Q; CHROMOSOME 8Q; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE MUTATION; HUMAN; LYMPHEDEMA; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; TURNOVER TIME;

EID: 73949155854     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090637     Document Type: Article

References (49)

1. Weiss SW, Goldblum JR: Malignant vascular tumors. Soft tissue tumors. Edited by SW Weiss, and JR Goldblum. Mosby Elsevier, 2008, pp 703-750
2. Naka N, Ohsawa M, Tomita Y, Kanno H, Uchida A, Myoui A, Aozasa K: Prognostic factors in angiosarcoma: a multivariate analysis of 55 cases. J Surg Oncol 1996, 61:170-176
3. Meis-Kindblom JM, Kindblom LG: Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg Pathol 1998, 22:683-697
4. Fayette J, Martin E, Piperno-Neumann S, Le Cesne A, Robert C, Bonvalot S, Ranchere D, Pouillart P, Coindre JM, Blay JY: Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol 2007, 18:2030-2036
5. Deyrup AT, McKenney JK, Tighiouart M, Folpe AL, Weiss SW: Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases. Am J Surg Pathol 2008, 32:72-77
6. Stewart NJ, Pritchard DJ, Nascimento AG, Kang YK: Lymphangiosarcoma following mastectomy. Clin Orthop Relat Res 1995:135-141
7. Sordillo EM, Sordillo PP, Hajdu SI, Good RA: Lymphangiosarcoma after filarial infection. J Dermatol Surg Oncol 1981, 7:235-239
8. Nanus DM, Kelsen D, Clark DG: Radiation-induced angiosarcoma. Cancer 1987, 60:777-779
9. Huang J, Mackillop WJ: Increased risk of soft tissue sarcoma after radiotherapy in women with breast carcinoma. Cancer 2001, 92:172-180
10. Strobbe LJ, Peterse HL, van Tinteren H, Wijnmaalen A, Rutgers EJ: Angiosarcoma of the breast after conservation therapy for invasive cancer, the incidence and outcome. An unforseen sequela. Breast Cancer Res Treat 1998, 47:101-109
11. Hodgson NC, Bowen-Wells C, Moffat F, Franceschi D, Avisar E: Angiosarcomas of the breast: a review of 70 cases. Am J Clin Oncol 2007, 30:570-573
12. Vorburger SA, Xing Y, Hunt KK, Lakin GE, Benjamin RS, Feig BW, Pisters PW, Ballo MT, Chen L, Trent J 3rd, Burgess M, Patel S, Pollock RE, Cormier JN: Angiosarcoma of the breast. Cancer 2005, 104:2682-2688
13. Adhikari D, Hajdu SI, Levine D: Post-radiation angiosarcoma and bilateral mastectomy. Ann Clin Lab Sci 2002, 32:428-433
14. Monroe AT, Feigenberg SJ, Mendenhall NP: Angiosarcoma after breast-conserving therapy. Cancer 2003, 97:1832-1840
15. Tarkkanen M, Wiklund TA, Virolainen MJ, Larramendy ML, Mandahl N, Mertens F, Blomqvist CP, Tukiainen EJ, Miettinen MM, Elomaa AI, Knuutila YS: Comparative genomic hybridization of postirradiation sarcomas. Cancer 2001, 92:1992-1998
16. Mertens F, Larramendy M, Gustavsson A, Gisselsson D, Rydholm A, Brosjo O, Mitelman F, Knuutila S, Mandahl N: Radiation-associated sarcomas are characterized by complex karyotypes with frequent rearrangements of chromosome arm 3p. Cancer Genet Cytogenet 2000, 116:89-96
17. Nakanishi H, Tomita Y, Myoui A, Yoshikawa H, Sakai K, Kato Y, Ochi T, Aozasa K: Mutation of the p53 gene in postradiation sarcoma. Lab Invest 1998, 78:727-733
18. Brachman DG, Hallahan DE, Beckett MA, Yandell DW, Weichselbaum RR: p53 gene mutations and abnormal retinoblastoma protein in radiation-induced human sarcomas. Cancer Res 1991, 51:6393-6396
19. Gil-Benso R, Lopez-Gines C, Soriano P, Almenar S, Vazquez C, Llombart-Bosch A: Cytogenetic study of angiosarcoma of the breast. Genes Chromosomes Cancer 1994, 10:210-212
20. Naka N, Tomita Y, Nakanishi H, Araki N, Hongyo T, Ochi T, Aozasa K: Mutations of p53 tumor-suppressor gene in angiosarcoma. Int J Cancer 1997, 71:952-955
21. Baumhoer D, Gunawan B, Becker H, Fuzesi L: Comparative genomic hybridization in four angiosarcomas of the female breast. Gynecol Oncol 2005, 97:348-352
22. Cerilli LA, Huffman HT, Anand A: Primary renal angiosarcoma: a case report with immunohistochemical, ultrastructural, and cytogenetic features and review of the literature. Arch Pathol Lab Med 1998, 122:929-935
23. Schuborg C, Mertens F, Rydholm A, Brosjo O, Dictor M, Mitelman F, Mandahl N: Cytogenetic analysis of four angiosarcomas from deep and superficial soft tissue. Cancer Genet Cytogenet 1998, 100:52-56
24. Wong KF, So CC, Wong N, Siu LL, Kwong YL, Chan JK: Sinonasal angiosarcoma with marrow involvement at presentation mimicking malignant lymphoma: cytogenetic analysis using multiple techniques. Cancer Genet Cytogenet 2001, 129:64-68
25. Zu Y, Perle MA, Yan Z, Liu J, Kumar A, Waisman J: Chromosomal abnormalities and p53 gene mutation in a cardiac angiosarcoma. Appl Immunohistochem Mol Morphol 2001, 9:24-28
26. Mandahl N, Jin YS, Heim S, Willen H, Wennerberg J, Biorklund A, Mitelman F: Trisomy 5 and loss of the Y chromosome as the sole cytogenetic anomalies in a cavernous hemangioma/angiosarcoma. Genes Chromosomes Cancer 1990, 1:315-316
27. Kindblom LG, Stenman G, Angervall L: Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome. Virchows Arch A Pathol Anat Histopathol 1991, 419:439-445
28. Van den Berg E, Van Oven MW, de Jong B, Dam A, Wiersema J, Dijkhuizen T, Hoekstra HJ, Molenaar WM: Comparison of cytogenetic abnormalities and deoxyribonucleic acid ploidy of benign, borderline malignant, and different grades of malignant soft tissue tumors. Lab Invest 1994, 70:307-313
29. Guillou L, Coindre JM, Bonichon F, Nguyen BB, Terrier P, Collin F, Vilain MO, Mandard AM, Le Doussal V, Leroux A, Jacquemier J, Duplay H, Sastre-Garau X, Costa J: Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol 1997, 15:350-362
30. Yoneda S, Marx A, Muller-Hermelink HK: Low-grade metaplastic carcinomas of the thymus: biphasic thymic epithelial tumors with mesenchymal metaplasia-an update. Pathol Res Pract 1999, 195:555-563
31. Zielinski B, Gratias S, Toedt G, Mendrzyk F, Stange DE, Radlwimmer B, Lohmann DR, Lichter P: Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization. Genes Chromosomes Cancer 2005, 43:294-301
32. Hoischen A, Landwehr C, Kabisch S, Ding XQ, Trost D, Stropahl G, Wigger M, Radlwimmer B, Weber RG, Haffner D: Array-CGH in unclear syndromic nephropathies identifies a microdeletion in Xq22.3-q23. Pediatr Nephrol 2009
33. Fensterer H, Radlwimmer B, Strater J, Buchholz M, Aust DE, Julie C, Radvanyi F, Nordlinger B, Belluco C, Van Cutsem E, Kohne CH, Kestler HA, Schwaenen C, Nessling M, Lutz MP, Lichter P, Gress TM: Matrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks. BMC Cancer 2007, 7:58
34. Hildenbrand R, Niedergethmann M, Marx A, Belharazem D, Allgayer H, Schleger C, Strobel P: Amplification of the urokinase-type-plasminogen activator-receptor (uPAR) gene in ductal pancreatic carcinomas identifies a clinical high risk group. Am J Pathol 2009, 174:2246-2253
35. Liu J, Martin HJ, Liao G, Hayward SD: The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc. J Virol 2007, 81:10451-10459
36. Tarkkanen M, Larramendy ML, Bohling T, Serra M, Hattinger CM, Kivioja A, Elomaa I, Picci P, Knuutila S: Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry. Eur J Cancer 2006, 42:1172-1180
37. Morrison C, Radmacher M, Mohammed N, Suster D, Auer H, Jones S, Riggenbach J, Kelbick N, Bos G, Mayerson J: MYC amplification and polysomy 8 in chondrosarcoma: array comparative genomic hybridization, fluorescent in situ hybridization, and association with outcome. J Clin Oncol 2005, 23:9369-9376
38. Lualdi E, Modena P, Debiec-Rychter M, Pedeutour F, Teixeira MR, Facchinetti F, Dagrada GP, Pilotti S, Sozzi G: Molecular cytogenetic characterization of proximal-type epithelioid sarcoma. Genes Chromosomes Cancer 2004, 41:283-290
39. Schneider-Stock R, Boltze C, Jager V, Epplen J, Landt O, Peters B, Rys J, Roessner A: Elevated telomerase activity, c-MYC-, and hTERT mRNA expression: association with tumour progression in malignant lipomatous tumours. J Pathol 2003, 199:517-525
40. Squire JA, Pei J, Marrano P, Beheshti B, Bayani J, Lim G, Moldovan L, Zielenska M: High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. Genes Chromosomes Cancer 2003, 38:215-225
41. Scionti I, Michelacci F, Pasello M, Hattinger CM, Alberghini M, Manara MC, Bacci G, Ferrari S, Scotlandi K, Picci P, Serra M: Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma. Ann Oncol 2008, 19:1500-1508
42. Marampon F, Ciccarelli C, Zani BM: Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors. Mol Cancer 2006, 5:31
43. Jain M, Arvanitis C, Chu K, Dewey W, Leonhardt E, Trinh M, Sundberg CD, Bishop JM, Felsher DW: Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science 2002, 297:102-104
44. Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D: Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. Genomics 1992, 13:475-478
45. Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, Breitman M, Alitalo K: Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 1998, 282:946-949
46. Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Yla-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K: Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008, 454:656-660
47. Evans AL, Brice G, Sotirova V, Mortimer P, Beninson J, Burnand K, Rosbotham J, Child A, Sarfarazi M: Mapping of primary congenital lymphedema to the 5q35.3 region. Am J Hum Genet 1999, 64:547-555
48. Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, McTigue MA, Alitalo K, Finegold DN: Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema. Nat Genet 2000, 25:153-159
49. Partanen TA, Alitalo K, Miettinen M: Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors. Cancer 1999, 86:2406-2412