Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process

International Journal of Pharmaceutics

Volumn 427, Issue 2, 2012, Pages 385-392

  Tan, Yinhe ^a   Yang, Zhiwen ^a   Pan, Xin ^a   Chen, Meiwan ^a,b   Feng, Min ^a   Wang, Lili ^c   Liu, Hu ^c   Shan, Ziyun ^a   Wu, Chuanbin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b University of Macau   (Macao)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Aerosolization; Fine particle fraction; Nanoparticle; Pressurized metered dose inhaler; Stability; Thymopentin

Indexed keywords

CINEOLE; FLUORINATED HYDROCARBON; HEPTANE; NANOPARTICLE; PHOSPHATIDYLCHOLINE; THYMOPENTIN; WATER;

AEROSOL; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG FORMULATION; DRUG STABILITY; ENVIRONMENTAL TEMPERATURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METERED DOSE INHALER; NANOFABRICATION; PARTICLE SIZE; PRESSURE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; WATER CONTENT;

ADJUVANTS, IMMUNOLOGIC; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; CHLOROFLUOROCARBONS, METHANE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXANOLS; DRUG STABILITY; DRUG STORAGE; HEPTANES; HYDROCARBONS, FLUORINATED; LECITHINS; METERED DOSE INHALERS; MICROSCOPY, ELECTRON, TRANSMISSION; MONOTERPENES; NANOPARTICLES; PARTICLE SIZE; THYMOPENTIN;

EID: 84862805742     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.02.002     Document Type: Article

References (38)

1. T.B. Adams, S.M. Cohen, J. Doull, V.J. Feron, J.I. Goodman, L.J. Marnett, I.C. Munro, and P.S. Portoghese The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients Food Chem. Toxicol. 42 2004 157 185
2. P.J. Anderson Delivery options and devices for aerosolized therapeutics Chest 120 2001 89 93
3. G. Brambilla, T. Church, D. Lewis, and B. Meakin Plume temperature emitted from metered dose inhalers Int. J. Pharm. 405 2011 9 15
4. G. Brambilla, D. Ganderton, R. Garzia, D. Lewis, B. Meakin, and P. Ventura Modulation of aerosol clouds produced by pressurised inhalation aerosols Int. J. Pharm. 186 1999 53 61
5. A. Brindley The chlorofluorocarbon to hydrofluoroalkane transition: the effect on pressurized metered dose inhaler suspension stability J. Allergy Clin. Immunol. 104 1999 221 226
6. P. Byron Towards the rational formulation of metered dose inhalers J. Biopharm. Sci. 3 1992 1 9
7. U. Chokshi, P. Selvam, L. Porcar, and S.R. da Rocha Reverse aqueous emulsions and microemulsions in HFA227 propellant stabilized by non-ionic ethoxylated amphiphiles Int. J. Pharm. 369 2009 176 184
8. R.O. Cook, R.K. Pannu, and I.W. Kellaway Novel sustained release microspheres for pulmonary drug delivery J. Control. Release 104 2005 79 90
9. P.A. Dickinson, S.W. Howells, and I.W. Kellaway Novel nanoparticles for pulmonary drug administration J. Drug Targ. 9 2001 295 302
10. B.M. Eckhardt, J.Q. Oeswein, and T.A. Bewley Effect of freezing on aggregation of human growth hormone Pharm. Res. 8 1991 1360 1364
11. J.D. Engstrom, J.M. Tam, M.A. Miller, R.O. Williams 3rd, and K.P. Johnston Templated open flocs of nanorods for enhanced pulmonary delivery with pressurized metered dose inhalers Pharm. Res. 26 2009 101 117
12. G. Goldstein, M.P. Scheid, E.A. Boyse, D.H. Schlesinger, and J. Van Wauwe A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin Science 204 1979 1309
13. T. Koseki, N. Kitabatake, and E. Doi Freezing denaturation of ovalbumin at acid pH J. Biochem. 107 1990 389
14. H.Y. Li, and P.C. Seville Novel pMDI formulations for pulmonary delivery of proteins Int. J. Pharm. 385 2010 73 78
15. Y.Z. Li, X. Sun, T. Gong, J. Liu, J. Zuo, and Z.R. Zhang Inhalable microparticles as carriers for pulmonary delivery of thymopentin-loaded solid lipid nanoparticles Pharm. Res. 27 2010 1977 1986
16. A. Meziani, D. Touraud, A. Zradba, M. Clausse, and W. Kunz Co-surfactant properties of ketones J. Mol. Liq. 84 2000 301 311
17. A. Meziani, A. Zradba, D. Touraud, M. Clausse, and W. Kunz Can aldehydes participate in the nanostructuration of liquids containing charged micelles? J. Mol. Liq. 73 1997 107 118
18. B.K. Nyambura, I.W. Kellaway, and K.M.G. Taylor Insulin nanoparticles: stability and aerosolization from pressurized metered dose inhalers Int. J. Pharm. 375 2009 114 122
19. B.K. Nyambura, I.W. Kellaway, and K.M.G. Taylor The processing of nanoparticles containing protein for suspension in hydrofluoroalkane propellants Int. J. Pharm. 372 2009 140 146
20. F. Qian, N. Ni, J.W. Chen, S. Desikan, V. Naringrekar, M.A. Hussain, N.P. Barbour, and R.L. Smith Formation of zinc-peptide spherical microparticles during lyophilization from tert-butyl alcohol/water co-solvent system Pharm. Res. 25 2008 2799 2806
21. B.E. Rabinow Nanosuspensions in drug delivery Nat. Rev. Drug Discov. 3 2004 785 796
22. H.D.C. Smyth The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers Adv. Drug Deliv. Rev. 55 2003 807 828
23. Y. Takeuchi, Y. Ono, N. Hisanaga, J. Kitoh, and Y. Sugiura A comparative study on the neurotoxicity of n-pentane, n-hexane, and n-heptane in the rat Brit. J. Ind. Med. 37 1980 241
24. Y. Takeuchi, Y. Ono, N. Hisanaga, J. Kitoh, and Y. Sugiura A comparative study of the toxicity of n-pentane, n-hexane, and n-heptane to the peripheral nerve of the rat Clin. Toxicol. 18 1981 1395
25. J.M. Tam, J.D. Engstrom, D. Ferrer, R.O. Williams, and K.P. Johnston Templated open flocs of anisotropic particles for pulmonary delivery with pressurized metered dose inhalers J. Pharm. Sci. 99 2010 3150 3165
26. Y. Tan, Z. Yang, X. Peng, F. Xin, Y. Xu, M. Feng, C. Zhao, H. Hu, and C. Wu A novel bottom-up process to produce nanoparticles containing protein and peptide for suspension in hydrofluoroalkane propellants Int. J. Pharm. 413 2011 167 173
27. C. Telang, and R. Suryanarayanan Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol-water cosolvent system Pharm. Res. 22 2005 153 160
28. N. Tsapis, D. Bennett, B. Jackson, D.A. Weitz, and D.A. Edwards Trojan particles: large porous carriers of nanoparticles for drug delivery Proc. Natl. Acad. Sci. U.S.A. 99 2002 12001 12005
29. S. Verma, B.D. Huey, and D.J. Burgess Scanning probe microscopy method for nanosuspension stabilizer selection Langmuir 25 2009 12481 12487
30. C. Vervaet, and P.R. Byron Drug-surfactant-propellant interactions in HFA-formulations Int. J. Pharm. 186 1999 13 30
31. L. Wang, Y. Zhang, and X. Tang Characterization of a new inhalable thymopentin formulation Int. J. Pharm. 375 2009 1 7
32. R.O. Williams 3rd, M. Repka, and J. Liu Influence of propellant composition on drug delivery from a pressurized metered-dose inhaler Drug Dev. Ind. Pharm. 24 1998 763 770
33. L. Wu, M. Al-Haydari, and S.R.P. da Rocha Novel propellant-driven inhalation formulations: engineering polar drug particles with surface-trapped hydrofluoroalkane-philes Eur. J. Pharm. Sci. 33 2008 146 158
34. L. Wu, B. Bharatwaj, J. Panyam, and S.R.P. da Rocha Core-shell particles for the dispersion of small polar drugs and biomolecules in hydrofluoroalkane propellants Pharm. Res. 25 2008 289 301
35. L. Wu, and S.R.P. da Rocha Biocompatible and biodegradable copolymer stabilizers for hydrofluoroalkane dispersions: a colloidal probe microscopy investigation Langmuir 23 2007 12104 12110
36. L. Wu, J. Zhang, and W. Watanabe Physical and chemical stability of drug nanoparticles Adv. Drug. Deliv. Rev. 63 2011 456 469
37. L.B. Wu, R.P.S. Peguin, and S.R.P. Da Rocha Understanding solvation in hydrofluoroalkanes: ab initio calculations and chemical force microscopy J. Phys. Chem. B 111 2007 8096 8104
38. J. Zhang, L. Wu, H.-K. Chan, and W. Watanabe Formation, characterization, and fate of inhaled drug nanoparticles Adv. Drug Deliv. Rev. 63 2011 441 455