Design of Potent, Non-Toxic Antimicrobial Agents Based upon the Structure of the Frog Skin Peptide, Temporin-1CEb from Chinese Brown Frog, Rana chensinensis

Chemical Biology and Drug Design

Volumn 79, Issue 5, 2012, Pages 653-662

  Shang, Dejing ^a,b   Li, Xiaofan ^a   Sun, Yue ^a   Wang, Che ^b   Sun, Li ^a   Wei, Shi ^a   Gou, Meng ^a,b  

^a LIAONING NORMAL UNIVERSITY   (China)

^b Liaoning Provincial Key Lab of Biotechnology and Drug Discovery   (China)

Author keywords

Cationicity; Depolarization; Haemolytic activity; Hydrophobicity; Membrane integrity

Indexed keywords

DEXTRO K5 PEPTIDE; DEXTRO K5V2 PEPTIDE; DEXTRO K6V2 PEPTIDE; LEVO K5 PEPTIDE; LEVO K5V1 PEPTIDE; LEVO K6 PEPTIDE; LEVO K6V1 PEPTIDE; LEVO K6V2 PEPTIDE; LYSINE; POLYPEPTIDE ANTIBIOTIC AGENT; TEMPORIN 1CEB; TRIFLUOROETHANOL; UNCLASSIFIED DRUG; WATER;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; BACTERIAL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENTEROBACTER AEROGENES; ENTEROBACTER CLOACAE; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; FROG; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HYDROPHILICITY; HYDROPHOBICITY; KLEBSIELLA PNEUMONIAE; LACTOCOCCUS LACTIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; RANA CHENSINENSIS; SKIN; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; AMPHIBIAN PROTEINS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BACTERIAL INFECTIONS; HEMOLYSIS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RANIDAE; SKIN;

ANURA; NEGIBACTERIA; POSIBACTERIA; RANA CHENSINENSIS; STAPHYLOCOCCUS AUREUS;

EID: 84862805298     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2012.01363.x     Document Type: Article

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