-
1
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov, R., Preston-Hurlburt, P. & Janeway, C.A.J. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397 (1997).
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway, C.A.J.3
-
2
-
-
0033618562
-
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
-
Brightbill, H.D. et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285, 732-736 (1999).
-
(1999)
Science
, vol.285
, pp. 732-736
-
-
Brightbill, H.D.1
-
3
-
-
77951073629
-
NOD2 and Toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis
-
Ferwerda, G. et al. NOD2 and Toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog. 1, 279-285 (2005).
-
(2005)
PLoS Pathog.
, vol.1
, pp. 279-285
-
-
Ferwerda, G.1
-
4
-
-
0023039277
-
Learning from leprosy: A perspective on immunology and the third world
-
Bloom, B.R. Learning from leprosy: A perspective on immunology and the third world. J. Immunol. 137, i-x (1986).
-
(1986)
J. Immunol.
, vol.137
-
-
Bloom, B.R.1
-
5
-
-
0013931934
-
Classification of leprosy according to immunity. A five-group system
-
Ridley, D.S. & Jopling, W.H. Classification of leprosy according to immunity. A five-group system. Int. J. Lepr. Other Mycobact. Dis. 34, 255-273 (1966).
-
(1966)
Int. J. Lepr. Other Mycobact. Dis.
, vol.34
, pp. 255-273
-
-
Ridley, D.S.1
Jopling, W.H.2
-
6
-
-
0026095666
-
Defining protective responses to pathogens: Cytokine profiles in leprosy lesions
-
Yamamura, M. et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254, 277-279 (1991).
-
(1991)
Science
, vol.254
, pp. 277-279
-
-
Yamamura, M.1
-
7
-
-
0026012259
-
Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
-
Salgame, P. et al. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254, 279-282 (1991).
-
(1991)
Science
, vol.254
, pp. 279-282
-
-
Salgame, P.1
-
8
-
-
0033083397
-
CD1 expression by dendritic cells in human leprosy lesions: Correlation with effective host immunity
-
Sieling, P.A. et al. CD1 expression by dendritic cells in human leprosy lesions: Correlation with effective host immunity. J. Immunol. 162, 1851-1858 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 1851-1858
-
-
Sieling, P.A.1
-
9
-
-
0036644042
-
Role of TLR1 in mediating immune response to microbial lipoproteins
-
Takeuchi, O. et al. Role of TLR1 in mediating immune response to microbial lipoproteins. J. Immunol. 169, 10-14 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 10-14
-
-
Takeuchi, O.1
-
10
-
-
0038578610
-
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
-
Krutzik, S.R. et al. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat. Med. 9, 525-532 (2003).
-
(2003)
Nat. Med.
, vol.9
, pp. 525-532
-
-
Krutzik, S.R.1
-
11
-
-
0034891984
-
Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients
-
Kang, T.J. & Chae, G.T. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol. Med. Microbiol. 31, 53-58 (2001).
-
(2001)
FEMS Immunol. Med. Microbiol.
, vol.31
, pp. 53-58
-
-
Kang, T.J.1
Chae, G.T.2
-
12
-
-
0036436470
-
A polymorphism in the Toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy
-
Kang, T.J., Lee, S.B. & Chae, G.T. A polymorphism in the Toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy. Cytokine 20, 56-62 (2002).
-
(2002)
Cytokine
, vol.20
, pp. 56-62
-
-
Kang, T.J.1
Lee, S.B.2
Chae, G.T.3
-
13
-
-
0037378655
-
Cutting edge: A Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling
-
Bochud, P.Y., Hawn, T.R. & Aderem, A. Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J. Immunol. 170, 3451-3454 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 3451-3454
-
-
Bochud, P.Y.1
Hawn, T.R.2
Aderem, A.3
-
14
-
-
0038466165
-
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR
-
Schröder, N.W. et al. High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J. Mol. Med. 81, 368-372 (2003).
-
(2003)
J. Mol. Med.
, vol.81
, pp. 368-372
-
-
Schröder, N.W.1
-
15
-
-
4043156257
-
Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation
-
Kang, T.J., Yeum, C.E., Kim, B.C., You, E.Y. & Chae, G.T. Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation. Immunology 112, 674-680 (2004).
-
(2004)
Immunology
, vol.112
, pp. 674-680
-
-
Kang, T.J.1
Yeum, C.E.2
Kim, B.C.3
You, E.Y.4
Chae, G.T.5
-
16
-
-
17144400786
-
TLR2 Arg677Trp polymorphism in leprosy: Revisited
-
Malhotra, D., Relhan, V., Reddy, B.S. & Bamezai, R. TLR2 Arg677Trp polymorphism in leprosy: revisited. Hum. Genet. 116, 413-415 (2005).
-
(2005)
Hum. Genet.
, vol.116
, pp. 413-415
-
-
Malhotra, D.1
Relhan, V.2
Reddy, B.S.3
Bamezai, R.4
-
17
-
-
34250205895
-
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy
-
Johnson, C.M. et al. Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J. Immunol. 178, 7520-7524 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 7520-7524
-
-
Johnson, C.M.1
-
18
-
-
48949118047
-
Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction
-
Misch, E.A. et al. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl. Trop. Dis. 2, e231 (2008).
-
(2008)
PLoS Negl. Trop. Dis.
, vol.2
-
-
Misch, E.A.1
-
19
-
-
67650486394
-
Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions
-
Schuring, R.P. et al. Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. J. Infect. Dis. 199, 1816-1819 (2009).
-
(2009)
J. Infect. Dis.
, vol.199
, pp. 1816-1819
-
-
Schuring, R.P.1
-
20
-
-
37548999003
-
NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2
-
Yang, Y. et al. NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2. J. Biol. Chem. 282, 36223-36229 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 36223-36229
-
-
Yang, Y.1
-
21
-
-
0012722659
-
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
-
Girardin, S.E. et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869-8872 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8869-8872
-
-
Girardin, S.E.1
-
22
-
-
74049127960
-
Genomewide association study of leprosy
-
Zhang, F.R. et al. Genomewide association study of leprosy. N. Engl. J. Med. 361, 2609-2618 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2609-2618
-
-
Zhang, F.R.1
-
23
-
-
77950954449
-
Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states
-
Berrington, W.R. et al. Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. J. Infect. Dis. 201, 1422-1435 (2010).
-
(2010)
J. Infect. Dis.
, vol.201
, pp. 1422-1435
-
-
Berrington, W.R.1
-
24
-
-
20944442160
-
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
-
Krutzik, S.R. et al. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat. Med. 11, 653-660 (2005).
-
(2005)
Nat. Med.
, vol.11
, pp. 653-660
-
-
Krutzik, S.R.1
-
25
-
-
35948999345
-
+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences
-
+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences. Immunology 122, 522-531 (2007).
-
(2007)
Immunology
, vol.122
, pp. 522-531
-
-
Niazi, K.R.1
-
26
-
-
42149144651
-
Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
-
Netea, M.G. et al. Interleukin-32 induces the differentiation of monocytes into macrophage-like cells. Proc. Natl. Acad. Sci. USA 105, 3515-3520 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 3515-3520
-
-
Netea, M.G.1
-
27
-
-
33748369134
-
Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism
-
Netea, M.G. et al. Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism. PLoS Med. 3, e277 (2006).
-
(2006)
PLoS Med.
, vol.3
-
-
Netea, M.G.1
-
28
-
-
77951629953
-
IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages
-
Bai, X. et al. IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J. Immunol. 184, 3830-3840 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 3830-3840
-
-
Bai, X.1
-
29
-
-
47949093903
-
Endogenous IL-32 controls cytokine and HIV-1 production
-
Nold, M.F. et al. Endogenous IL-32 controls cytokine and HIV-1 production. J. Immunol. 181, 557-565 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 557-565
-
-
Nold, M.F.1
-
30
-
-
44849104379
-
Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection
-
Li, W. et al. Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection. PLoS ONE 3, e1985 (2008).
-
(2008)
PLoS ONE
, vol.3
-
-
Li, W.1
-
31
-
-
33644765841
-
IL-32, a proinflammatory cytokine in rheumatoid arthritis
-
Joosten, L.A. et al. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 103, 3298-3303 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 3298-3303
-
-
Joosten, L.A.1
-
32
-
-
34547887644
-
Epithelial overexpression of interleukin-32α in inflammatory bowel disease
-
Shioya, M. et al. Epithelial overexpression of interleukin-32α in inflammatory bowel disease. Clin. Exp. Immunol. 149, 480-486 (2007).
-
(2007)
Clin. Exp. Immunol.
, vol.149
, pp. 480-486
-
-
Shioya, M.1
-
33
-
-
42949095542
-
Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function
-
Marcondes, A.M. et al. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Proc. Natl. Acad. Sci. USA 105, 2865-2870 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 2865-2870
-
-
Marcondes, A.M.1
-
34
-
-
40049098041
-
LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells
-
Lee, D.J. et al. LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J. Immunol. 179, 8128-8136 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 8128-8136
-
-
Lee, D.J.1
-
35
-
-
0141818360
-
Use of genetic profiling in leprosy to discriminate clinical forms of the disease
-
Bleharski, J.R. et al. Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science 301, 1527-1530 (2003).
-
(2003)
Science
, vol.301
, pp. 1527-1530
-
-
Bleharski, J.R.1
-
36
-
-
72649097644
-
Divergence of macrophage phagocytic and antimicrobial programs in leprosy
-
Montoya, D. et al. Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe 6, 343-353 (2009).
-
(2009)
Cell Host Microbe
, vol.6
, pp. 343-353
-
-
Montoya, D.1
-
37
-
-
0028980830
-
CD1-restricted T cell recognition of microbial lipoglycans
-
Sieling, P.A. et al. CD1-restricted T cell recognition of microbial lipoglycans. Science 269, 227-230 (1995).
-
(1995)
Science
, vol.269
, pp. 227-230
-
-
Sieling, P.A.1
-
38
-
-
0027232912
-
Immunosuppressive roles for interleukin-10 and interleukin-4 in human infection: In vitro modulation of T cell responses in leprosy
-
Sieling, P.A. et al. Immunosuppressive roles for interleukin-10 and interleukin-4 in human infection: in vitro modulation of T cell responses in leprosy. J. Immunol. 150, 5501-5510 (1993).
-
(1993)
J. Immunol.
, vol.150
, pp. 5501-5510
-
-
Sieling, P.A.1
-
39
-
-
58149182886
-
IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway
-
Krutzik, S.R. et al. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J. Immunol. 181, 7115-7120 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 7115-7120
-
-
Krutzik, S.R.1
-
40
-
-
0028289244
-
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor αa
-
Sallusto, F. & Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor αa. J. Exp. Med. 179, 1109-1118 (1994).
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1109-1118
-
-
Sallusto, F.1
Lanzavecchia, A.2
-
41
-
-
0026474183
-
Mycobacterium leprae 65hsp antigen expressed from a retroviral vector in a macrophage cell line is presented to T cells in association with MHC class II in addition to MHC class I
-
Silva, C.L., Palacios, A., Colston, M.J. & Lowrie, D.B. Mycobacterium leprae 65hsp antigen expressed from a retroviral vector in a macrophage cell line is presented to T cells in association with MHC class II in addition to MHC class I. Microb. Pathog. 12, 27-38 (1992).
-
(1992)
Microb. Pathog.
, vol.12
, pp. 27-38
-
-
Silva, C.L.1
Palacios, A.2
Colston, M.J.3
Lowrie, D.B.4
-
42
-
-
0020697098
-
T lymphocyte subsets in the skin lesions of patients with leprosy
-
Modlin, R.L., Hofman, F.M., Taylor, C.R. & Rea, T.H. T lymphocyte subsets in the skin lesions of patients with leprosy. J. Am. Acad. Dermatol. 8, 182-189 (1983).
-
(1983)
J. Am. Acad. Dermatol.
, vol.8
, pp. 182-189
-
-
Modlin, R.L.1
Hofman, F.M.2
Taylor, C.R.3
Rea, T.H.4
-
44
-
-
66749174867
-
The inflammasomes: Guardians of the body
-
Martinon, F., Mayor, A. & Tschopp, J. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229-265 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 229-265
-
-
Martinon, F.1
Mayor, A.2
Tschopp, J.3
-
45
-
-
0000161413
-
The treatment of malignant tumors by repeated inoculations of erysipelas: With a report of ten original cases
-
Coley, W.B. The treatment of malignant tumors by repeated inoculations of erysipelas: With a report of ten original cases. Am. J. Med. Sci. 105, 487-511 (1893).
-
(1893)
Am. J. Med. Sci.
, vol.105
, pp. 487-511
-
-
Coley, W.B.1
-
46
-
-
0017130525
-
Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors
-
Morales, A., Eidinger, D. & Bruce, A.W. Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors. J. Urol. 116, 180-183 (1976).
-
(1976)
J. Urol.
, vol.116
, pp. 180-183
-
-
Morales, A.1
Eidinger, D.2
Bruce, A.W.3
-
47
-
-
0014825236
-
Immunological factors which influence response to immunotherapy in malignant melanoma
-
Morton, D., Eilber, F.R., Malmgren, R.A. & Wood, W.C. Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery 68, 158-163 (1970).
-
(1970)
Surgery
, vol.68
, pp. 158-163
-
-
Morton, D.1
Eilber, F.R.2
Malmgren, R.A.3
Wood, W.C.4
-
48
-
-
0015964141
-
Adjuvant activity of monomeric bacterial cell wall peptidoglycans
-
Adam, A., Ciorbaru, R., Ellouz, F., Petit, J.F. & Lederer, E. Adjuvant activity of monomeric bacterial cell wall peptidoglycans. Biochem. Biophys. Res. Commun. 56, 561-567 (1974).
-
(1974)
Biochem. Biophys. Res. Commun.
, vol.56
, pp. 561-567
-
-
Adam, A.1
Ciorbaru, R.2
Ellouz, F.3
Petit, J.F.4
Lederer, E.5
-
49
-
-
0016200846
-
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives
-
Ellouz, F., Adam, A., Ciorbaru, R. & Lederer, E. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem. Biophys. Res. Commun. 59, 1317-1325 (1974).
-
(1974)
Biochem. Biophys. Res. Commun.
, vol.59
, pp. 1317-1325
-
-
Ellouz, F.1
Adam, A.2
Ciorbaru, R.3
Lederer, E.4
-
50
-
-
0017803750
-
Stimulation of an enhanced in vitro immune response by a synthetic adjuvant, muramyl dipeptide
-
Specter, S., Cimprich, R., Friedman, H. & Chedid, L. Stimulation of an enhanced in vitro immune response by a synthetic adjuvant, muramyl dipeptide. J. Immunol. 120, 487-491 (1978).
-
(1978)
J. Immunol.
, vol.120
, pp. 487-491
-
-
Specter, S.1
Cimprich, R.2
Friedman, H.3
Chedid, L.4
-
51
-
-
0017857357
-
Enhancement of carrier-specific helper T cell function by the synthetic adjuvant, N-acetyl muramyl-l-alanyl-d-isoglutamine (MDP)
-
Sugimoto, M., Germain, R.N., Chedid, L. & Benacerraf, B. Enhancement of carrier-specific helper T cell function by the synthetic adjuvant, N-acetyl muramyl-l-alanyl-d-isoglutamine (MDP). J. Immunol. 120, 980-982 (1978).
-
(1978)
J. Immunol.
, vol.120
, pp. 980-982
-
-
Sugimoto, M.1
Germain, R.N.2
Chedid, L.3
Benacerraf, B.4
-
52
-
-
0026592464
-
Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid)
-
Kleinerman, E.S. et al. Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid). Cancer Immunol. Immunother. 34, 211-220 (1992).
-
(1992)
Cancer Immunol. Immunother.
, vol.34
, pp. 211-220
-
-
Kleinerman, E.S.1
-
53
-
-
0016325178
-
Histological classification and the immunological spectrum of leprosy
-
Ridley, D.S. Histological classification and the immunological spectrum of leprosy. Bull. World Health Organ. 51, 451-465 (1974).
-
(1974)
Bull. World Health Organ.
, vol.51
, pp. 451-465
-
-
Ridley, D.S.1
-
54
-
-
33645224419
-
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
-
Liu, P.T. et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311, 1770-1773 (2006).
-
(2006)
Science
, vol.311
, pp. 1770-1773
-
-
Liu, P.T.1
-
55
-
-
0037203867
-
TH1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
-
Monney, L. et al. TH1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415, 536-541 (2002).
-
(2002)
Nature
, vol.415
, pp. 536-541
-
-
Monney, L.1
|