Protective role of α-galactosylceramide-stimulated natural killer T cells in genital tract infection with Chlamydia muridarum

FEMS Immunology and Medical Microbiology

Volumn 65, Issue 1, 2012, Pages 43-54

  Wang, Hong ^a   Zhao, Lei ^a   Peng, Ying ^a   Liu, Juan ^a   Qi, Mei ^a   Chen, Qiang ^a   Yang, Xi ^b   Zhao, Weiming ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

galactosylceramide; Chlamydia; Genital tract infection; Host defense; NKT cells

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHLAMYDIA; CHLAMYDIASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENITAL TRACT INFECTION; HOST RESISTANCE; IMMUNE RESPONSE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

ANIMALS; BACTERIAL LOAD; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GALACTOSYLCERAMIDES; LYMPH NODES; MICE; MICE, INBRED BALB C; NATURAL KILLER T-CELLS; REPRODUCTIVE TRACT INFECTIONS;

EID: 84862804011     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2012.00939.x     Document Type: Article

References (48)

1. Behar SM, Dascher CC, Grusby MJ, Wang CR & Brenner MB (1999) Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J Exp Med 189: 1973-1980.
2. Bendelac A, Savage PB & Teyton L (2007) The biology of NKT cells. Annu Rev Immunol 25: 297-336.
3. Bharhani MS, Chiu B, Na KS & Inman RD (2009) Activation of invariant NKT cells confers protection against Chlamydia trachomatis-induced arthritis. Int Immunol 21: 859-870.
4. Bilenki L, Wang S, Yang J, Fan Y, Joyee AG & Yang X (2005) NK T cell activation promotes Chlamydia trachomatis infection in vivo. J Immunol 175: 3197-3206.
5. + dendritic cells (DC) isolated from mice infected with Chlamydia muridarum are potent in inducing protective immunity than CD8α- DC. J Immunol 177: 7067-7075.
6. Brunham RC & Rey-Ladino J (2005) Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nat Rev Immunol 5: 149-161.
7. Brunham RC, Zhang DJ, Yang X & McClarty GM (2000) The potential for vaccine development against chlamydial infection and disease. J Infect Dis 181: S538-S543.
8. + NK T lymphocytes. J Immunol 161: 3271-3281.
9. Carnaud C, Lee D, Donnars O, Park SH, Beavis A, Koezuka Y & Bendelac A (1999) Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol 163: 4647-4650.
10. Choi HJ, Xu H, Geng Y, Colmone A, Cho H & Wang CR (2008) Bacterial infection alters the kinetics and function of NKT cell responses. J Leukoc Biol 84: 1462-1471.
11. Cotter TW, Ramsey KH, Miranpuri GS, Poulsen CE & Byrne GI (1997) Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Infect Immun 65: 2145-2152.
12. Fidel PL Jr, Wolf NA & KuKuruga MA (1996) T lymphocytes in the murine vaginal mucosa are phenotypically distinct from those in the periphery. Infect Immun 64: 3793-3799.
13. Geng Y, Berencsi K, Gyulai Z, Valyi-Nagy T, Gonczol E & Trinchieri G (2000) Roles of interleukin-12 and interferon in murine Chlamydia pneumoniae infection. Infect Immun 68: 2245-2253.
14. Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ & Baxter AG (2000) NKT cells: facts, functions and fallacies. Immunol Today 21: 573-583.
15. Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ & Van Kaer L (2004) NKT cells: what's in a name? Nat Rev Immunol 4: 231-237.
16. Grubor-Bauk B, Simmons A, Mayrhofer G & Speck PG (2003) Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant Vα 14-Jα 281 TCR. J Immunol 170: 1430-1434.
17. Johansson M, Schon K, Ward M & Lycke N (1997) Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response. Infect Immun 65: 1032-1044.
18. Joyee AG, Qiu H, Wang S, Fan Y, Bilenki L & Yang X (2007) Distinct NKT cell subsets are induced by different Chlamydia species leading to differential adaptive immunity and host resistance to the infections. J Immunol 178: 1048-1058.
19. Joyee AG, Qiu H, Fan Y, Wang S & Yang X (2008) Natural killer T cells are critical for dendritic cells to induce immunity in Chlamydial pneumonia. Am J Respir Crit Care Med 178: 745-756.
20. Kawakami K, Kinjo Y, Yara S, Koguchi Y, Uezu K, Nakayama T, Taniguchi M & Saito A (2001) Activation of Vα14 natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans. Infect Immun 69: 213-220.
21. α14 NKT cells by glycosylceramides. Science 278: 1626-1629.
22. Kim S, Lalani S, Parekh VV, Vincent TL, Wu L & Van Kaer L (2008) Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J Clin Invest 118: 2301-2315.
23. Kronenberg M (2005) Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 26: 877-900.
24. Li W, Murthy AK, Guentzel MN, Seshu J, Forsthuber TG, Zhong G & Arulanandam BP (2008) Antigen-specific CD4 T cells produce sufficient IFN-γ to mediate robust protective immunity against genital Chlamydia muridarum infection. J Immunol 180: 3375-3382.
25. Liu J, Wang X, Zhou G, Wang H, Xiang L, Cheng Y, Liu W, Wang Y, Jia J & Zhao W (2011) Cancerous inhibitor of protein phosphatase 2A is overexpressed in cervical cancer and upregulated by human papillomavirus 16 E7 oncoprotein. Gynecol Oncol 122: 430-436.
26. Lü H, Wang H, Zhao HM et al. (2010) Dendritic cells (DCs) transfected with a recombinant adenovirus carrying chlamydial major outer membrane protein antigen elicit protective immune responses against genital tract challenge infection. Biochem Cell Biol 88: 757-765.
27. Magee DM, Williams DM, Smith JG, Bleicker CA, Grubbs BG, Schachter J & Rank RG (1995) Role of CD8 T cells in primary Chlamydia infection. Infect Immun 63: 516-521.
28. Miller CJ, McChesney M & Moore PF (1992) Langerhans cells, macrophages and lymphocyte subsets in the cervix and vagina of Rhesus macaques. Lab Invest 67: 628-634.
29. Morrison RP & Caldwell HD (2002) Immunity to murine chlamydial genital infection. Infect Immun 70: 2741-2751.
30. Murthy AK, Chambers JP, Meier PA, Zhong G & Arulanandam BP (2007) Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production. Infect Immun 75: 666-676.
31. Nagarajan UM, Prantner D, Sikes JD, Andrews CW Jr, Goodwin AM, Nagarajan S & Darville T (2008) Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model. Infect Immun 76: 4642-4648.
32. Nieda M, Nicol A, Koezuka Y et al. (1999) Activation of human Vα24NKT cells by α-glycosylceramide in a CD1d-restricted and Vα24 TCR-mediated manner. Hum Immunol 60: 10-19.
33. Nieuwenhuis EE, Matsumoto T, Exley M, Schleipman RA, Glickman J, Bailey DT, Corazza N, Colgan SP, Onderdonk AB & Blumberg RS (2002) CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med 8: 588-593.
34. Nusbaum MR, Wallace RR, Slatt LM & Kondrad EC (2004) Sexually transmitted infections and increased risk of co-infection with human immunodeficiency virus. J Am Osteopath Assoc 104: 527-535.
35. Pal S, Barnhart KM, Wei Q, Abai AM, Peterson EM & de la Maza LM (1999) Vaccination of mice with DNA plasmids coding for the Chlamydia trachomatis major outer membrane protein elicits an immune response but fails to protect against a genital challenge. Vaccine 17: 459-465.
36. Perry LL, Feilzer K & Caldwell HD (1998) Neither interleukin-6 nor inducible nitric oxide synthase is required for clearance of Chlamydia trachomatis from the murine genital tract epithelium. Infect Immun 66: 265-1269.
37. Rank RG (1994) Animal models for urogenital infections. Methods Enzymol 235: 83-93.
38. Ronet C, Darche S, Leite de Moraes M, Miyake S, Yamamura T, Louis JA, Kasper LH & Buzoni-Gatel D (2005) NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii. J Immunol 175: 899-908.
39. Silins I, Ryd W, Strand A et al. (2005) Chlamydia trachomatis infection and persistence of human papillomavirus. Int J Cancer 16: 110-115.
40. Singh N, Hong S, Scherer DC, Serizawa I, Burdin N, Kronenberg M, Koezuka Y & Van Kaer L (1999) Cutting edge: activation of NK T cells by CD1d and α-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J Immunol 163: 2373-2377.
41. Su H & Caldwell HD (1995) CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect Immun 63: 3302-3308.
42. Tonti E, Galli G, Malzone C, Abrignani S, Casorati G & Dellabona P (2009) NKT-cell help to B lymphocytes can occur independently of cognate interaction. Blood 113: 370-376.
43. Tseng CT & Rank RG (1998) Role of NK cells in early host response to chlamydial genital infection. Infect Immun 66: 5867-5875.
44. Williams DM, Grubbs BG, Darville T, Kelly K & Rank RG (1998) A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection. Infect Immun 66: 4564-4567.
45. World Health Organization (2001) Global Prevalence and Incidence of Selected Curable Sexually Transmitted Infections: Overview and Estimates. World Health Organization, Geneva.
46. Yang X, HayGlass KT & Brunham RC (1996) Genetically determined differences in IL-10 and IFN-γ responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection. J Immunol 156: 4338-4344.
47. Zhang D, Yang X, Berry J, Shen C, McClarty G & Brunham RC (1997) DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection. J Infect Dis 176: 1035-1040.
48. Zheng Y, Zhao WM, Wang H et al. (2007) Codon usage bias in Chlamydia trachomatis and the effect of codon modification in the MOMP gene on immune responses to vaccination. Biochem Cell Biol 85: 218-226.