NKT-cell help to B lymphocytes can occur independently of cognate interaction

Blood

Volumn 113, Issue 2, 2009, Pages 370-376

  Tonti, Elena ^a   Galli, Grazia ^b   Malzone, Carmine ^b   Abrignani, Sergio ^c   Casorati, Giulia ^a   Dellabona, Paolo ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^c Istituto Nazionale di Genetica Molecolare   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; ANTIGEN; CD1D ANTIGEN; CD40 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; ALPHA-GALACTOSYLCERAMIDE; GALACTOSYLCERAMIDE; HLA ANTIGEN CLASS 2; IMMUNOLOGICAL ADJUVANT;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL ACTIVATION; CELL FUNCTION; CELL INTERACTION; CELLULAR IMMUNITY; HELPER CELL; IMMUNIZATION; INNATE IMMUNITY; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; RADIATION; SPLEEN; SPLENECTOMY; WILD TYPE; ANIMAL; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; BONE MARROW TRANSPLANTATION; CELL COMMUNICATION; DRUG EFFECT; GENETICS; HISTOCOMPATIBILITY; IMMUNOLOGY; MOUSE MUTANT; PHYSIOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODY FORMATION; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD1D; ANTIGENS, CD40; B-LYMPHOCYTES; BONE MARROW TRANSPLANTATION; CELL COMMUNICATION; GALACTOSYLCERAMIDES; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNITY, INNATE; IMMUNIZATION; MICE; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; T-LYMPHOCYTES, HELPER-INDUCER; TRANSPLANTATION CHIMERA;

EID: 58849166273     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-06-166249     Document Type: Article

References (38)

1. McHeyzer-Williams LJ, McHeyzer-Williams MG. Antigen-specific memory B cell development. Annu Rev Immunol. 2005;23:487-513.
2. MacLennan IC. Germinal centers. Annu Rev Immunol. 1994;12:117-139.
3. O'Hagan DT, Valiante NM. Recent advances in the discovery and delivery of vaccine adjuvants. Nat Rev Drug Discov. 2003;2:727-735.
4. Vogel FR. Improving vaccine performance with adjuvants. Clin Infect Dis. 2000;30(suppl 3): S266-S270.
5. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol. 2007;25:297-336.
6. Lantz O, Bendelac A. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8-T cells in mice and humans. J Exp Med. 1994;180:1097-1106.
7. Dellabona P, Padovan E, Casorati G, Brockhaus M, LanzavecchiaA. An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J Exp Med. 1994;180:1171-1176.
8. Bendelac A, Lantz O, Quimby ME, Yewdell JW, Bennink JR, Brutkiewicz RR. CD1 recognition by mouse NK1 + T lymphocytes. Science. 1995;268: 863-865.
9. Exley M, Garcia J, Balk SP, Porcelli S. Requirements for CD1d recognition by human invariant Valpha24+ CD4-CD8-T cells. J Exp Med. 1997; 186:109-120.
10. Brigl M, Brenner MB. CD1: antigen presentation and T cell function. Annu Rev Immunol. 2004;22: 817-890.
11. Im JS, Tapinos N, Chae GT, et al. Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NKT cells. J Immunol. 2006;177:5226-5235.
12. KawanoT, Cui J, Koezuka Y, et al. CD1d-restricted andTCR-mediated activation ofvalpha14 NKT cells by glycosylceramides. Science. 1997; 278:1626-1629.
13. Brossay L, Chioda M, Burdin N, et al. CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J Exp Med. 1998; 188:1521-1528.
14. Bendelac A, Bonneville M, Kearney JF. Autoreactivity by design: innate B and T lymphocytes. Nat Rev Immunol. 2001;1:177-186.
15. Van Kaer L. alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat Rev Immunol. 2005;5:31-42.
16. Nieda M, Okai M, TazbirkovaA, et al. Therapeutic activation of Valpha24+Vbeta11 + NKTcells in human subjects results in highly coordinated secondary activation of acquired and innate immunity. Blood. 2004;103:383-389.
17. Gonzalez-AseguinolazaG, Van Kaer L Bergmann CC, et al. Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J Exp Med. 2002;195:617-624.
18. Fujii SI, Shimizu K, Smith C, Bonifaz L, Steinman RM. Activation of natural killer T cells by {alpha}-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8Tcell immunity to a coadministered protein. J Exp Med. 2003;198:267-279.
19. Bezbradica JS, Stanic AK, Matsuki N, et al. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J Immunol. 2005;174:4696-4705.
20. Fujii S, Shimizu K, Smith C, Bonifaz L, Steinman RM. Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8Tcell immunity to a coadministered protein. J Exp Med. 2003;198:267-279.
21. Fujii S, Liu K, Smith C, Bonito AJ, Steinman RM. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med. 2004;199: 1607-1618.
22. Hermans IF, Silk JD, Gileadi U, et al. NKTcells enhance CD4+ and CD8+ Tcell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol. 2003;171:5140-5147.
23. Galli G, Nuti S, Tavarini S, et al. CD1d-restricted help to B cells by human invariant natural killer T lymphocytes. J Exp Med. 2003;197:1051-1057.
24. Galli G, Pittoni P, Tonti E, et al. Invariant NKT cells sustain specific B cell responses and memory. Proc Natl Acad Sci USA. 2007;104: 3984-3989.
25. Smiley ST, Kaplan MH, Grusby MJ. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 1997;275:977-979.
26. Kitamura D, Roes J, Kuhn R, Rajewsky K. AB cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 1991;350:423-426.
27. Kawabe T, Naka T, Yoshida K, et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity. 1994;1:167-178.
28. Cosgrove D, Gray D, Dierich A, et al. Mice lacking MHC class II molecules. Cell. 1991;66:1051-1066.
29. Fillatreau S, Gray D. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med. 2003; 197:195-206.
30. Schümann J, Pittoni P, Tonti E, Macdonald HR, Dellabona P, Casorati G. Targeted expression of human CD1d in transgenic mice reveals independent roles for thymocytes and thymic APCs in positive and negative selection of Valpha14i NKT cells. J Immunol. 2005;175:7303-7310.
31. Lang GA, Devera TS, Lang ML. Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production. Blood. 2008;111: 2158-2162.
32. Mattner J, Savage PB, Leung P, et al. Liver auto-immunity triggered by microbial activation of natural killer T cells. Cell Host Microbe. 2008;3:304-315.
33. Barral P, Eckl-Dorna J, Harwood NE, et al. B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo. Proc Natl Acad Sci U SA. 2008;105:8345-8350.
34. Leadbetter EA, Brigl M, Illarionov P, et al. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A. 2008;105: 8339-8344.
35. Allman D, Pillai S. Peripheral B cell subsets. Curr Opin Immunol. 2008;20:149-157.
36. Matsuda JL, Naidenko OV, Gapin L, et al. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med. 2000;192:741-754.
37. Kool M, Soullie T, van Nimwegen M, et al. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med. 2008;205:869-882.
38. Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature. 2008; 453:1122-1126.