Activation of invariant NKT cells confers protection against Chlamydia trachomatis-induced arthritis

International Immunology

Volumn 21, Issue 7, 2009, Pages 859-870

  Bharhani, Mantej Singh ^a   Chiu, Basil ^a   Na, Kyoung Sun ^a   Inman, Robert D ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

GalCer; C. trachomatis; Cytokines; iNKT cells; Reactive arthritis

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD1D ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTHRITIS; CELL FUNCTION; CHLAMYDIA TRACHOMATIS; CHLAMYDIA TRACHOMATIS INDUCED ARTHRITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; HISTOPATHOLOGY; IMMUNOREGULATION; KNEE ARTHRITIS; KNOCKOUT MOUSE; MALE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYNOVIUM; T LYMPHOCYTE ACTIVATION; WILD TYPE;

ANIMALS; ANTIGENS, CD1D; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, INFECTIOUS; CHEMOKINE CXCL10; CHEMOKINE CXCL2; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; GALACTOSYLCERAMIDES; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67649846614     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxp052     Document Type: Article

References (38)

1. - T cells in mice and humans. J. Exp. Med. 180:1097.
2. Brigl, M. and Brenner, M. B. 2004. CD1: Antigen presentation and T cell function. Annu. Rev. Immunol. 22:817.
3. Zhou, D., Mattner, J., Cantu, C. et al. 2004. Lysosomal glycosphingolipid recognition by NKT cells. Science 306:1786.
4. Zhang, X., Pacheco-Tena, C. and Inman, R. D. 2003. Microbe hunting in the joints. Arthritis Rheum. 49:479.
5. Inman, R. D., Perl, A. and Phillips, P. E. 2005. Infectious agents in chronic rheumatic diseases. In Koopman, W. J. and Moreland, L. W., eds, Arthritis and allied conditions: A textbook of rheumatology, Lippincott Williams & Wilkins, Philadelphia, PA. p. 647.
6. Inman, R. D., Whittum-Hudson, J. A., Schumacher, H. A. and Hudson, A. P. 2000. Chlamydia and associated arthritis. Curr. Opin. Rheumatol. 12:254.
7. Inman, R. D. and Chiu, B. 1998. Synoviocyte-packaged Chlamydia trachomatis induces a chronic aseptic arthritis. J. Clin. Invest. 102:1776.
8. Inman, R. D. and Chiu, B. 2006. Early cytokine profiles in the joint define pathogen clearance and severity of arthritis in Chlamydia-induced arthritis in rat. Arthritis Rheum. 54:499.
9. + T cells produce large amount of IL-4 and IFN-γ upon activation by anti-CD3 or CD1d. J. Immunol. 159:2240.
10. Smyth, M. J. and Godfrey, D. J. 2000. NKT cells and tumor immunity - a double-edged sword. Nat. Immunol. 1:459.
11. Linsen, L., Thewissen, M., Baeten, K. et al. 2005. Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis. Arthritis. Res. Ther. 7:R493.
12. Kim, H. Y., Kim, H. J., Min, H. S. et al. 2005. NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production. J. Exp. Med. 201:41.
13. Coppieters, K., Van Beneden, K., Jacques, P. et al. 2007. A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner. J. Immunol. 179:2300.
14. Ohnishi, Y., Tsutsumi, A., Goto, D. et al. 2005. TCR Valpha14 natural killer T cells function as effector T cells in mice with collagen-induced arthritis. Clin. Exp. Immunol. 141:47.
15. Chackerian, A., Alt, J., Perera, V. and Behar, S. M. 2002. Activation of NKT cells protects mice from tuberculosis. Infect. Immun. 70:6302.
16. Mukhopadhyay, S., Clark, A. P., Sullivan, E. D., Miller, R. D. and Summersgill, J. T. 2004. Detailed protocol for purification of Chlamydia pneumoniae elementary bodies. J. Clin. Microbiol. 42:3288.
17. Yang, Y. H. and Hamilton, J. A. 2001. Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor. Arthritis Rheum. 44:111.
18. Zhang, X., Glogauer, M., Zhou, F., Kim, T. H., Chiu, B. and Inman, R. D. 2005. Innate immunity and arthritis: Neutrophil Rac and toll-like receptor 4 expression define outcomes in infection-triggered arthritis. Arthritis Rheum. 52:1297.
19. Butler, D. M., Malfait, A. M., Mason, L. J. et al. 1997. DBA/1 mice expressing the human TNF-alpha transgene develop a severe erosive arthritis: Characterization of cytokine cascade and cellular composition. J. Immunol. 159:2867.
20. Burns, T., Abadi, M. and Pirofski, L. A. 2005. Modulation of the lung inflammatory response to serotype 8 pneumococcal infection by a human immunoglobulin m monoclonal antibody to serotype 8 capsular polysaccharide. Infect. Immun. 73:4530.
21. + cells are each sufficient for protection against Chlamydia pneumoniae infection through their ability to secrete IFN-γ. J. Immunol. 172:2407.
22. Nieuwenhuis, E. E., Matsumoto, T., Exley, M. et al. 2002. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat. Med. 8:588.
23. Yin, Z., Braun, J., Neure, J. et al. 1997. Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis. Arthritis Rheum. 40:1788.
24. Braun, J., Yin, Z., Spiller, I. et al. 1999. Low secretion of tumor necrosis factor alpha, but no other Th1 or Th2 cytokines, by peripheral blood mononuclear cells correlates with chronicity in reactive arthritis. Arthritis Rheum. 42:2039.
25. Ramsey, K. H., Miranpuri, G. S., Sigar, I. M., Ouellette, O. and Byrne, G. I. 2002. Chlamydia trachomatis persistence in the female mouse genital tract: Inducible nitric oxide synthase and infection outcome. Infect. Immun. 69:5131.
26. Kamata, K., Kamijo, S., Nakajima, A. et al. 2006. Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis. J. Immunol. 177:6433.
27. Hanaoka, R., Kasama, T., Muramatsu, M. et al. 2003. A novel mechanism for the regulation of IFN-gamma inducible protein-10 expression in rheumatoid arthritis. Arthritis Res. Ther. 5:R74.
28. Gangur, V., Simons, F. E. and Hayglass, K. T. 1998. Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-gamma over IL-4 responses. FASEB J. 12:707.
29. Patel, D. D., Zachariah, J. P. and Whichard, L. P. 2001. CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. Clin. Immunol. 98:39.
30. Proost, P., Vynckier, A. K., Mahieu, F. et al. 003. Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis. Eur. J. Immunol. 33: 3146.
31. Salomon, I., Netzer, N., Wildbaum, G., Schif-Zuck, S., Maor, G. and Karin, N. 2002. Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis. J. Immunol. 169:2685.
32. Rodriguez, N., Fend, F., Jennen, L. et al. 2005. Polymorphonuclear neutrophils improve replication of Chlamydia pneumoniae in vivo upon MyD88-dependent attraction. J. Immunol. 174:4836.
33. Cao, Y., Brombacher, F., Tunyogi-Csapo, M., Glant, T. T. and Finnegan, A. 2007. Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response. Arthritis Rheum. 56:861.
34. Gasperini, S., Marchi, M., Calzetti, F. et al. 1999. Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils. J. Immunol. 162:4928.
35. Ito, S., Ansari, P., Sakatsume, M. et al. 1999. Interleukin-10 inhibits expression of both interferon alpha- and interferon gammainduced genes by suppressing tyrosine phosphorylation of STAT1. Blood 93:1456.
36. Miellot, A., Zhu, R., Diem, S., Boissier, M. C., Herbelin, A. and Bessis, N. 2005. Activation of invariant NK T cells protects against experimental rheumatoid arthritis by an IL-10-dependent pathway. Eur. J. Immunol. 35:3704.
37. Kinjo, Y. and Kronenberg, M. 2005. Valpha14i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes. J. Clin. Immunol. 25:522.
38. Bilenki, L., Wang, S., Yang, J., Fan, Y., Joyee, A. G. and Yang, X. 2005. NK T cell activation promotes Chlamydia trachomatis infection in vivo. J. Immunol. 175:3197.