Neither interleukin-6 nor inducible nitric oxide synthase is required for clearance of Chlamydia trachomatis from the murine genital tract epithelium

Infection and Immunity

Volumn 66, Issue 3, 1998, Pages 1265-1269

  Perry, Linda L ^a   Feilzer, Karen ^a   Caldwell, Harlan D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; ENZYME INDUCTION; FEMALE; GENE MUTATION; GENE TARGETING; HOST RESISTANCE; IMMUNOCOMPETENCE; INFECTION RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031935085     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.3.1265-1269.1998     Document Type: Article

References (43)

1. Adams, L. B., J. B. J. Hibbs, R. R. Taintor, and J. L. Krahenbuhl. 1990. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii: role for synthesis of inorganic nitrogen oxides from L-arginine. J. Immunol. 144:2725-2729.
2. Anthony, L. S. D., P. J. Morrissey, and F. E. Nano. 1992. Growth inhibition of Francisella tularensis live vaccine strain by IFN-γ-activated macrophages is mediated by reactive nitrogen intermediates derived from L-arginine metabolism. J. Immunol. 148:1829-1834.
3. Barteneva, N., I. Theodor, E. M. Peterson, and L. M. de la Maza. 1996. Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection. Infect. Immun. 64:4830-4833.
4. Beckerman, K. P., H. W. Rogers, J. A. Corbett, R. D. Schreiber, M. L. McDaniel, and E. R. Unanue. 1993. Release of nitric oxide during the T cell-independent pathway of macrophage activation. J. Immunol. 150:888-895.
5. Bernad, A., M. Kopf, R. Kulbacki, N. Welch, G. Koehler, and J. C. Gutierrez-Ramos. 1994. Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity 1:725-731.
6. Boockvar, K. S., D. L. Granger, R. M. Poston, M. Maybodi, M. K. Washington, J. B. Hibbs, and R. L. Kurlander. 1994. Nitric oxide produced during murine listeriosis is protective. Infect. Immun. 62:1089-1100.
7. Bromander, A. K., L. Ekman, M. Kopf, J. G. Nedrud, and N. Y. Lycke. 1996. IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection. J. Immunol. 156:4290-4297.
8. Cain, T. K., and R. G. Rank. 1995. Local Th1-like responses are induced by intravaginal infection of mice with the mouse pneumonitis biovar of Chlamydia trachomatis. Infect. Immun. 63:1784-1789.
9. Chai, Z., S. Gatti, C. Toniatti, V. Poli, and T. Bartfai. 1996. Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: a study on IL-6-deficient mice. J. Exp. Med. 183:311-316.
10. Chan, J., K. Tanaka, D. Carroll, J. Flynn, and B. R. Bloom. 1995. Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect. Immun. 63:736-740.
11. Chen, B., R. Stout, and W. F. Campbell. 1996. Nitric oxide production: a mechanism of Chlamydia trachomatis inhibition in interferon-gamma-treated RAW264.7 cells. FEMS Immunol. Med. Microbiol. 14:109-120.
12. Cobb, J. P., and R. L. Danner. 1996. Nitric oxide and septic shock. JAMA 275:1192-1196.
13. Cotter, T. W., K. H. Ramsey, G. S. Miranpuri, C. E. Poulsen, and G. I. Byrne. 1997. Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Infect. Immun. 65:2145-2152.
14. Cressman, D. E., L. E. Greenbaum, R. A. DeAngelis, G. Ciliberto, E. E. Furth, P. V., and T. R. 1996. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274:1379-1383.
15. Dalrymple, S. A., L. A. Lucian, R. Slattery, T. McNeil, D. M. Aud, S. Fuchino, F. Lee, and R. Murray. 1995. Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect. Immun. 63:2262-2268.
16. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407-2412.
17. Doherty, T. M., and A. Sher. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J. Immunol. 158:4822-4831.
18. Fehr, T., G. Schoedon, B. Odermatt, T. Holtschke, M. Schneemann, M. F. Bachmann, T. W. Mak, I. Horak, and R. M. Zinkernagel. 1997. Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis. J. Exp. Med. 185:921-931.
19. Gauldie, J., C. Richards, and H. Baumann. 1992. IL-6 and the acute phase reaction. Res. Immunol. 143:755-759.
20. Guler, M. L., N. G. Jacobson, U. Gubler, and K. M. Murphy. 1997. T cell genetic background determines maintenance of IL-12 signaling. J. Immunol. 159:1767-1774.
21. Henttinen, T., D. E. Levy, S. O., and M. Hurme. 1995. Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response: critical role for IL-6. J. Immunol. 155:4582-4587.
22. Igietseme, J. U. 1996. The molecular mechanism of T-cell control of Chlamydia in mice: role of nitric oxide. Immunology 87:1-8.
23. Igietseme, J. U. 1996. Molecular mechanism of T-cell control of Chlamydia in mice: role of nitric oxide in vivo. Immunology 88:1-5.
24. Igietseme, J. U., I. M. Uriri, R. Hawkins, and R. G. Rank. 1996. Integrin-mediated epithelial-T cell interaction enhances nitric oxide production and increased intracellular inhibition of Chlamydia. J. Leukocyte Biol. 59:656-662.
25. Jacobs, P., D. Radzioch, and M. M. Stevenson. 1996. In vivo regulation of nitric oxide production by tumor necrosis factor alpha and gamma interteron, but not by interleukin-4, during blood stage malaria in mice. Infect. Immun. 64:44-49.
26. James, S. L., and J. Glaven. 1989. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J. Immunol. 143:4208-4212.
27. Kolb, H., and V. Kolb-Bachofen. 1992. Nitric oxide: a pathogenetic factor in autoimmunity. Immunol. Today 13:157-160.
28. Kushima, Y., T. Hama, and H. Hatanaka. 1992. Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains. Neurosci. Res. 13:267-280.
29. Laubach, V. E., E. G. Shesely, O. Smithies, and P. A. Sherman. 1995. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc. Natl. Acad. Sci. USA 92:10688-10692.
30. Liew, F. Y., S. Millott, C. Parkinson, R. M. J. Palmer, and S. Moncada. 1990. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J. Immunol. 144:4794-4797.
31. Lotz, M. 1995. Interleukin-6: a comprehensive review. Cancer Treatment Res. 80:209-233.
32. MacMicking, J. D., C. Nathan, G. Horn, N. Chartrain, D. S. Fletcher, M. Trumbauer, K. Stevens, Q.-W. Xie, K. Sokol, N. Hutchinson, H. Chen, and J. S. Mudgett. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650.
33. Meyaard, L., E. Hovenkamp, S. A. Otto, and F. Miedema. 1996. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J. Immunol. 156:2776-2782.
34. Morrison, R. P., K. Feilzer, and D, B. Tumas. 1995. Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection. Infect. Immun. 63:4661-4668.
35. Perry, L. L., K. Feilzer, and H. D. Caldwell. 1997. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-γ-dependent and -independent pathways. J. Immunol. 158:3344-3352.
36. Ramsay, A. J., A. J. Husband, I. A. Ramshaw, S. Bao, K. I. Matthaei, G. Koehler, and M. Kopf. 1994. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 264:561-563.
37. Salkowski, C. A., S. A. Barber, G. R. Detore, and S. N. Vogel. 1996. Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IFN regulatory factor-1 and -2 genes. J. Immunol. 156:3107-3110.
38. Schachter, J. 1989. Pathogenesis of chlamydial infections. Pathol. Immunopathol. Res. 8:206-220.
39. Scharton-Kersten, T. M., G. Yap, J. Magram, and A. Sher. 1997. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J. Exp. Med. 185:1261-1273.
40. Seguin, M. C., F. W. Klotz, I. Schneider, J. P. Weir, M. Goodbary, M. Slayter, J. J. Raney, J. U. Aniagolu, and S. J. Green. 1994. Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon γ and CD8+ T cells. J. Exp. Med. 180:353-358.
41. + T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect. Immun. 63:3302-3308.
42. Su, H., K. Feilzer, H. D. Caldwell, and R. P. Morrison. 1997. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect. Immun. 65:1993-1999.
43. Vouldoukis, I., V. Riveros-Moreno, B. Dugas, F. Ouaaz, P. Becherel, P. Debre, S. Moncada, and M. D. Mossalayi. 1995. The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the FcεRII/CD23 surface antigen. Proc. Natl. Acad. Sci. USA 92: 7804-7808.