Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-L-cysteine and aspirin

International Immunology

Volumn 8, Issue 10, 1996, Pages 1483-1493

  Sakurada, Shinsaku ^a,b   Kato, Tetsuji ^a   Okamoto, Takashi ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

ICAM 1; NF B; Proinflammatory cytokine; Rheumatoid arthritis; Synovial fibroblasts

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CASE REPORT; CONTROLLED STUDY; FIBROBLAST; GENE TRANSLOCATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM;

ACETYLCYSTEINE; ARTHRITIS, RHEUMATOID; ASPIRIN; CELLS, CULTURED; CYTOKINES; FIBROBLASTS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1; NF-KAPPA B; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029842020     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.10.1483     Document Type: Article

References (49)

1. Firestein, G. S. and Zvaifler, N. J. 1992. Rheumatoid arthritis: a disease of disordered immunity. In Gallin, J., Goldstein and Willis, K., eds, Inflammation, 2nd edn. Raven Press, New York.
2. Firestein, G. S. and Zvaifler, N. J. 1991. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum. 33:768.
3. Alvaro-Gracia, J. M., Zvaifler, N. J. and Firestein, G. S. 1989. Cytokines in chronic inflammatory arthritis. IV. Granulocyte / macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis. J. Exp. Med. 170:865.
4. Alvaro-Gracia, J. M., Zvaifler, N. J. and Firestein, G. S. 1990. Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between IFN-γ and TNF-α on HLA-DR expression, proliferation, collagenase production, and GM-CSF production by rheumatoid arthritis synoviocytes. J. Clin. Invest. 86:1790.
5. Alvaro-Gracia, J. M., Zvaifler, N. J., Brown, C. B., Kaushansky, K. and Firestein, G. S. 1991. Cytokines in chronic arthritis. VI. Analysis of the synovial cells involved in granulocyte macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and TNF-α. J. Immunol. 146:3365.
6. Ulfgren, A. K., Lindblad, S. Klareskog, L., Andersson, J. and Andersson, U. 1995 Detection of cytokine producing cells in the synovial membrane from patients with rheumatoid arthritis. Ann. Rheum. Dis. 54:654.
7. Arend, W. P. and Dayer, J. M. 1995. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. Arthritis Rheum. 38:151.
8. Davis, L. S., Kavanaugh, A. F., Nichols, L. A. and Lipsky, P. E. 1995. Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis. J. Immunol. 154:3525.
9. Wicks, I. P., Leizer, T., Wawryk, S. O., Novotony, J. R., Hamilton, J., Vitti, G. and Boyd, A. W. 1992. The effect of cytokines on the expression of MHC antigens and ICAM-1 by normal and transformed synoviocytes. Autoimmunity. 12:13.
10. Blue, M. L., Conrad, P., Webb, D. L., Sarr, T. and Macaro, M. 1993. Interacting monocytes and synoviocytes induce adhesion molecules by a cytokine-regulated process. Lymphokine Cytokine Res. 12:213.
11. Wilkinson, L. S., Edwards, J. C. W., Poston, R. N. and Haskard, D. O. 1993. Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium. Lab. Invest. 68:82.
12. Brennan, F. M., Chantry, D., Jackson, A., Maini, R. and Feldmann, M. 1989. Inhibitory effect of TNFα antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet ii:244.
13. Elliott, M. J., Maini, R. N., Feldmann, M., Long-Fox, A., Charles, P., Katsikis, P., Brennan, F. M., Walker, J., Bijil, H., Ghrayeb, J. and Woody, J. N. 1993. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum. 36:1681
14. Baeuerle, P. A., 1991. The inducible transcription activator NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63.
15. Krasnow, S. W., Zhang, L., Leung, K. Osborn, L., Kunkel, S. and Nabel, G. 1991. Tumor necrosis factor-α, interleukin-1, and phorbol mynstate acetate are independent activators of NF-κB which differentially activate T cells. Cytokines 3:372.
16. Ledebur, H. C. and Parks, T. P. 1995. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential role of a variant NF-κB site and p65 homodimers. J. Biol. Chem. 270:933.
17. Stade, B. G., Messer, G., Riethmuller, G. and Johnson, J. P. 1990. Structural characteristics of the 5′ region of the human ICAM-1 gene. Immunobiology 182:79.
18. Mukaida, N., Mane, Y. and Matsushima, K. 1990. Cooperative interaction of nuclear factor-κB and cis-regulatory enhancer binding protein like factor elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J. Biol. Chem. 34:21128.
19. Eck, S. L., Perkins, N. D., Carr, D. P. and Nabel, G. B. 1993. Inhibition of phorbol ester-induced cellular adhesion by competitive binding of NF-κB in vivo. Mol. Cell. Biol. 13:6530.
20. Moynagh, P. N., Williams, D. C. and O'Neill, L. A. J. 1994. Activation of NF-κB and induction of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants. J. Immunol. 153:2681.
21. Kawai, M., Nishikomori, R., Jung, E. Y., Tai, G., Yamanaka, C., Mayumi, M. and Heike, T. 1995. Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. J. Immunol. 154:2333.
22. Sen, R. and Baltimore, D. 1986. Multiple nuclear factors interact with the immunoglobulin enhancer-binding sequence. Cell 46:705
23. Gilmore, T. D. 1990. NF-κB, KBF1, dorsal, and related matters Cell 62:841.
24. Baeuerle, P. A. and Baltimore, D. 1988. A specific inhibitor of the NF-κB transcription factor. Science 242:540.
25. Baeuerle, P. A. and Baltimore, D. 1988. Activation of DNA-binding activity in an apparently cytoplasmic precursor of NF-κB transcription factor. Cell 53:211.
26. Leonard, M. J. and Baltimore, D. 1989. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58:227.
27. Okamoto, T., Ogiwara, H., Hayashi, T., Mitsui, A., Kawabe, T. and Yodoi, J. 1992. Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism. Int. Immunol. 4:811.
28. Hayashi, T., Ueno, Y. and Okamoto, T. 1993. Oxidoreductive regulation of nuclear factor κB. Involvement of a cellular reducing catalyst thioredoxin. J. Biol. Chem. 268:11380.
29. Hayashi, T., Sekine, T. and Okamoto, T. 1993. Identification of a new serine kinase that activates NF-κB by direct phosphorylation. J. Biol. Chem. 268:26790.
30. Roederer, M., Staal, F. T. J., Raju, P. A., Ela, S. W., Herzenberg, L. A. and Herzenberg, L. A. 1990. Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc. Natl Acad. Sci. USA 87:4884.
31. Staal, F. J. T., Roederer, M., Herzenberg, L. A. and Herzenberg, L. A. 1990. Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus. Proc. Natl Acad. Sci. USA 87:9943.
32. Koop, E. and Ghosh, S. 1994. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265:956.
33. Weber, C., Erl, W., Pietsh, A. and Weber, P. C. 1995. Aspirin inhibits nuclear factor-κB mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation 91:1914.
34. Kitajima, I., Yamamoto, K., Sato, K., Nakajima, Y., Maruyama, I., Osame, M. and Nishioka, K. 1991. Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy. J. Clin. Invest. 88:1315.
35. Nakajima, T., Aono, H., Hasunuma, T., Yamamoto, K., Maruyama, I., Nosaka, T., Hatanaka, M. and Nishioka, K. 1993. Overgrowth of human synovial cells driven by human T cell leukemia virus type I tax gene. J. Clin. Invest. 92:186.
36. Goto, M., Sasano, M., Yamanaka, H., Miyasaka, N., Kamatani, N., Inoue, K., Nishioka, K. and Miyamoto, T. 1987. Spontaneous production of an interleukin1-like factor by cloned rheumatoid synovial cells in long-term culture. J. Clin. Invest. 80:786.
37. Tozawa, K., Sakurada, S., Kohri, K. and Okamoto, T. 1995. Effects of anti-nuclear factor κB reagents in blocking adhesion of human cancer cells to vascular endothelial cells. Cancer Res. 55:4162.
38. Read, M. A., Whitely, M. Z., Williams, A. J. and Collins, T. 1994. NF-κB and κB-α: an inducible regulatory system in endothelial activation. J. Exp. Med. 179:503.
39. Yang, J. P., Merin, J. P. Nakano, T., Kato, T., Kitade, Y. and Okamoto, T. 1995. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro. FEBS Lett. 361:89.
40. Donnelly, R. P., Crofford, L. J., Freeman, S. L. Buras, J., Remmers E., Wilder, R. L. and Fenton, M. J. 1993. Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-κB activity in monocytes and fibroblasts. J. Immunol. 151:5603.
41. Schreck, R., Rieber, P. and Baeuerle, P. A. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 10:2247.
42. Chin, J. E., Winterrowd, G. E., Krzesicki, R. F. and Sanders, M. E. 1990. Role of cytokines in inflammatory synovitis. The coordinate regulation of intercellular adhesion molecule-1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts. Arthritis Rheum. 33:1766.
43. Kavanaugh, A. F., Davis, L. S., Nichols, L. A., Norris, S. H., Rothlein, R., Scharshmidt, L. A. and Lipsky, P. E. 1994. Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule-1. Arthritis Rheum. 37:992.
44. Dechanet, J., Merville, P., Durand, I., Banchereau, J. and Miossec, P. 1995. The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium. J. Clin. Invest. 95:456.
45. van de Stlope, A., Caldenhoven, E., Stade, B. G., Koenderman, L., Raaijmarkers, J. A., Johnson, J. P. and van der Saag, P. T. 1994. 12-O-tetradecanonoylphorbol-13-acetate and tumor necrosis factor α mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecule-1 promoter J. Biol. Chem. 269:6185.
46. Pimentel-Muiños, F. X., Mazana, J. and Fresno, M. 1995. Biphasic control of nuclear factor-κB activation by the T cell receptor complex: role of tumor necrosis factor α. Eur. J. Immunol. 25:179.
47. Qin, J., Clore, G. M., Kennedy, W. M. P., Huth, J. R. and Gronenborn, A. M. 1995. Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF-κB. Structure 3:289.
48. Frantz, B. and O'Neill, E. A. 1995. The effect of sodium salicylate and aspirin on NF-κB. Science 270:2017.
49. Handel, M. L., McMorrow, L. B. and Gravallese, E. M. 1995. Nuclear factor-κB in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum. 38:1762.