Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 9, 2012, Pages 2992-2999

  Liu, Chang ^a,b   Jin, Jing ^a   Chen, Liang ^a,c   Zhou, Jie ^a   Chen, Xiaoguang ^a   Fu, Decai ^b   Song, Hongrui ^c   Xu, Bailing ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti cancer agents; Benzophenone; Pin1; Pin1 inhibitor; PPIase

Indexed keywords

(2 AMINO 5 NITROPHENYL) (3,4 DIMETHOXYPHENYL)METHANONE; (2 CHLORO 5 NITROPHENYL) (3 FLUORO 4 METHOXYPHENYL)METHANONE; (2 CHLORO 5 NITROPHENYL) (3,4 DIMETHOXYPHENYL)METHANONE; 2 (4 ACETAMIDO 2 BENZOYLPHENYLAMINO) 2 OXOACETIC ACID; 2 [2 BENZOYL 4 (1H INDOLE 2 CARBOXAMIDO)PHENYLAMINO] 2 OXOACETIC ACID; 2 [2 BENZOYL 4 (3 CHLOROBENZO[B]THIOPHENE 2 CARBOXAMIDO)PHENYLAMINO] 2 OXOACETIC ACID; 2 [2 BENZOYL 4 (6 NITROBENZO[B]THIOPHENE 2 CARBOXAMIDO)PHENYLAMINO] 2 OXOACETIC ACID; 2 [4 (BENZO[B]THIOPHENE 2 CARBOXAMIDO) 2 (3 FLUORO 4 METHOXYBENZOYL)PHENYLAMINO] 2 OXOACETIC ACID; 2 [4 (BENZO[B]THIOPHENE 2 CARBOXAMIDO) 2 (3,4 DIMETHOXYBENZOYL)PHENYLAMINO] 2 OXOACETIC ACID; 2 [4 (BENZO[B]THIOPHENE 2 CARBOXAMIDO) 2 BENZOYLPHENYLAMINO] 2 OXOACETIC ACID; 2 [4 (BENZO[B]THIOPHENE 3 CARBOXAMIDO) 2 (3,4 DIMETHOXYBENZOYL)PHENYLAMINO] 2 OXOACETIC ACID; 2 [4 (BENZO[B]THIOPHENE 3 CARBOXAMIDO) 2 BENZOYLPHENYLAMINO] 2 OXOACETIC ACID; 2 [4 (BENZOFURAN 2 CARBOXAMIDO) 2 BENZOYLPHENYLAMINO] 2 OXOACETIC ACID; BENZOPHENONE DERIVATIVE; ETHYL 2 (2 BENZOYL 4 NITROPHENYLAMINO) 2 OXOACETIC ACID; ETHYL 2 (4 ACETAMIDO 2 BENZOYLPHENYLAMINO) 2 OXOACETIC ACID; ETHYL 2 (4 AMINO 2 BENZOYLPHENYLAMINO) 2 OXOACETIC ACID; ETHYL 2 [2 (3,4 DIMETHOXYBENZOYL) 4 NITROPHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [2 BENZOYL 4 (1H INDOLE 2 CARBOXAMIDO)PHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [2 BENZOYL 4 (3 CHLOROBENZO[B]THIOPHENE 2 CARBOXAMIDO)PHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [2 BENZOYL 4 (6 NITROBENZO[B]THIOPHENE 2 CARBOXAMIDO)PHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [4 (BENZO[B]THIOPHENE 2 CARBOXAMIDO) 2 (3,4 DIMETHOXYBENZOYL)PHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [4 (BENZO[B]THIOPHENE 2 CARBOXAMIDO) 2 BENZOYLPHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [4 (BENZO[B]THIOPHENE 3 CARBOXAMIDO) 2 (3,4 DIMETHOXYBENZOYL)PHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [4 (BENZO[B]THIOPHENE 3 CARBOXAMIDO) 2 BENZOYLPHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [4 (BENZOFURAN 2 CARBOXAMIDO) 2 BENZOYLPHENYLAMINO] 2 OXOACETIC ACID; ETHYL 2 [4 AMINO 2 (3,4 DIMETHOXYBENZOYL)PHENYLAMINO] 2 OXOACETIC ACID; PEPTIDYLPROLYL ISOMERASE PIN1; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALGORITHM; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; DRUG BINDING; DRUG DESIGN; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALGORITHMS; BENZOPHENONES; BINDING SITES; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; PEPTIDYLPROLYL ISOMERASE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862796117     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.005     Document Type: Article

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