Structure-based design of novel human Pin1 inhibitors (II)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2210-2214

  Dong, Liming ^a   Marakovits, Joseph ^a   Hou, Xinjun ^a   Guo, Chuangxing ^a   Greasley, Samantha ^a   Dagostino, Eleanor ^a   Ferre, RoseAnn ^a   Johnson, M Catherine ^a   Kraynov, Eugenia ^a   Thomson, James ^a   Pathak, Ved ^a   Murray, Brion W ^a  

^a PFIZER INC   (United States)

Author keywords

Anti cancer agents; Carboxylates; Phosphate replacement; Pin1; Pin1 inhibitors; PPIase; SBDD; Tetrazoles

Indexed keywords

PEPTIDYLPROLYL ISOMERASE PIN1; PHOSPHATE; PROLINE; SULFONAMIDE; TETRAZOLE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN; PROTEIN INTERACTION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PEPTIDYLPROLYL ISOMERASE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949487897     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.033     Document Type: Article

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