E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells

Toxicology Letters

Volumn 210, Issue 1, 2012, Pages 78-86

  Hu, Chen ^a   Zou, Mei Juan ^a   Zhao, Li ^a   Lu, Na ^a   Sun, Ya Jing ^a   Gou, Shao Hua ^b   Xi, Tao ^a   Guo, Qing Long ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

Autophagy; Cell growth; E Platinum; Gastric carcinoma cells; MTOR

Indexed keywords

3 METHYLADENINE; ANTINEOPLASTIC AGENT; BECLIN 1; CATHEPSIN D; CHLOROQUINE; E PLATINUM; FLUORESCEIN ISOTHIOCYANATE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OXALIPLATIN; PLATINUM DERIVATIVE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CARCINOMA CELL; CELL COMPARTMENTALIZATION; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; FLUORESCENCE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RNA INTERFERENCE; STOMACH CARCINOMA;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; CARCINOMA; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; ORGANOPLATINUM COMPOUNDS; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TOR SERINE-THREONINE KINASES;

EID: 84862793242     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.01.019     Document Type: Article

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