X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3296-3300

  McLean, Larry R ^a   Zhang, Ying ^a   Zaidi, Nisha ^a   Bi, Xiping ^a   Wang, Rachel ^a   Dharanipragada, Ram ^a   Jurcak, John G ^a   Gillespy, Timothy A ^a   Zhao, Zhicheng ^a   Musick, Kwon Y ^a   Choi, Yong Mi ^a   Barrague, Matthieu ^b   Peppard, Jane ^c   Smicker, Matthew ^a   Duguid, Mei ^a   Parkar, Ashfaq ^a   Fordham, Jeremy ^a   Kominos, Dorothea ^a  

^a SANOFI   (France)

^b Sanofi US   (United States)

^c Early to Candidate   (United States)

Author keywords

Kinase; Kinase inhibitors; Protein crystallography; Structural biology; Structure activity relationship

Indexed keywords

3 INDOLE; 4 INDOLE; 5 INDOLE; ENZYME INHIBITOR; INDOLE; INTERLEUKIN 2 INDUCIBLE TYROSINE KINASE; PROTEIN TYROSINE KINASE; THIENOPYRAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862786957     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.016     Document Type: Article

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