Repeated treatment with haloperidol, but not olanzapine, alters synaptic NMDA receptor composition in rat striatum

European Neuropsychopharmacology

Volumn 18, Issue 7, 2008, Pages 531-534

  Gardoni, Fabrizio ^a   Frasca, Angelisa ^a   Zianni, Elisa ^a   Riva, Marco A ^a   Di Luca, Monica ^a   Fumagalli, Fabio ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Antipsychotic; ; CaMKII; ; NMDA receptor; ; Postsynaptic density; ; Rat; Striatum;

Indexed keywords

BRAIN PROTEIN; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; OLANZAPINE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; RECEPTOR SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG RECEPTOR BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SYNAPTIC MEMBRANE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CORPUS STRIATUM; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION; HALOPERIDOL; MALE; MEMBRANE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES; TIME FACTORS;

EID: 42449085277     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2007.10.004     Document Type: Article

References (20)

1. Bubser M., and Deutch A.Y. Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum. Eur. J. Neurosci. 15 (2002) 713-720
2. De Bartolomeis A., Aloj L., Ambesi-Impiombato A., Bravi D., Caraco C., Muscettola G., and Barone P. Acute administration of antipsychotics modulates Homer striatal gene expression differentially. Mol. Brain Res. 98 (2002) 124-129
3. Dwivedi Y., Rizavi H.S., and Pandey G.N. Differential effects of Haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. J. Pharmacol. Exp. Ther. 300 (2002) 197-209
4. Fumagalli F., Frasca A., Sparta M., Drago F., Racagni G., and Riva M.A. Long-term exposure to the atypical antipsychotic Olanzapine differently up-regulates extracellular signal-regulated kinases 1 and 2 phosphorylation in subcellular compartments of rat prefrontal cortex. Mol. Pharmacol. 69 (2006) 1366-1372
5. Gardoni F., Schrama L.H., Kamal A., Gispen W.H., Cattabeni F., and Di Luca M. Hippocampal synaptic plasticity involves competition between Ca2 + /calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. J. Neurosci. 21 (2001) 1501-1509
6. Gardoni F., Picconi B., Ghiglieri V., Polli F., Bagetta V., Bernardi G., Cattabeni F., Di Luca M., and Calabresi P. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. J. Neurosci. 26 (2006) 2914-2922
7. Groc L., and Choquet D. AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapse. Cell Tissue Res. 326 (2006) 423-438
8. Hallett P.J., Dunah A.W., Ravenscroft P., Zhou S., Bezard E., Crossman A.R., Brotchie J.M., and Standaert D.G. Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Neuropharmacology 48 (2005) 503-516
9. Hardingham G.E., Fukunaga Y., and Bading H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5 (2002) 405-414
10. Kapur S., VanderSpek S.C., Brownlee B.A., and Nobrega J.N. Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy. J. Pharmacol. Exp. Ther. 305 (2003) 625-631
11. Keefe R.S., Seidman L.J., Christensen B.K., Hamer R.M., Sharma T., Sitskoorn M.M., Rock S.L., Woolson S., Tohen M., Tollefson G.D., Sanger T.M., Lieberman J.A., and HGDH Research Group. Long-term neurocognitive effects of Olanzapine or low-dose Haloperidol in first-episode psychosis. Biol. Psychiatry (2006) 97-105
12. Mauceri D., Gardoni F., Marcello E., and Di Luca M. Dual role of CaMKII-dependent SAP97 phosphorylation in mediating trafficking and insertion of NMDA receptor subunit NR2A. J. Neurochem. 100 (2007) 1032-1046
13. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1996), Academic Press, New York
14. Picconi B., Tortiglione A., Barone I., Centone D., Gardoni F., Gubellini P., Bonsi P., Pisani A., Bernardi G., Di Luca M., and Calabresi P. NR2B subunit exerts a critical role in postischemic synaptic plasticity. Stroke 37 (2006) 1895-1901
15. Prybylowski K., and Wenthold R.J. N-methyl-d-aspartate receptors: subunit assembly and trafficking to the synapse. J. Biol. Chem. 279 (2004) 9673-9676
16. Riva M.A., Tascedda F., Lovati E., and Racagni G. Regulation of NMDA receptor subunit messenger RNA levels in the rat brain following acute and chronic exposure to antipsychotic drugs. Brain Res. Mol. Brain Res. 50 (1997) 136-142
17. Sans N., Prybylowski K., Petralia R.S., Chang K., Wang Y.X., Racca C., Vicini S., and Wenthold R.J. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat. Cell Biol. 5 (2003) 520-530
18. Schotte A., Janssen P.F., Gommeren W., Luyten W.H., Van Gompel P., Lesage A.S., De Loore K., and Leysen J.E. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 124 (1996) 57-73
19. Tarazi F.I., Baldessarini R.J., Kula N.S., and Zhang K. Long-term effects of Olanzapine, risperidone, and quetiapine on ionotropic glutamate receptor types: implications for antipsychotic drug treatment. J. Pharmacol. Exp. Ther. 306 (2003) 1145-1151
20. Yoshida Y., Ono T., Kawano K., and Miyagishi T. Distinct sites of dopaminergic and glutamatergic regulation of Haloperidol-induced catalepsy within the rat caudate-putamen. Brain Res. 639 (1994) 139-148 124:57-73