The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+-induced apoptosis

European Journal of Neuroscience

Volumn 17, Issue 8, 2003, Pages 1563-1570

  Qing, Hong ^a   Xu, Haiyun ^a   Wei, Zelan ^a   Gibson, Kurt ^a   Li, Xin Min ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Antipsychotics; Cell culture; Cell death; DNA fragmentation

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; COPPER ZINC SUPEROXIDE DISMUTASE; HALOPERIDOL; OLANZAPINE; QUETIAPINE; RISPERIDONE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG MECHANISM; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHIZOPHRENIA;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; ANTIPSYCHOTIC AGENTS; APOPTOSIS; BLOTTING, NORTHERN; DNA FRAGMENTATION; ENZYME ACTIVATION; GLYCOSYLATION; HALOPERIDOL; HERBICIDES; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 0038018122     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02590.x     Document Type: Article

References (51)

1. Altar, C.A., Wasley, A.M., Neale, R.F. & Stone, G.A. (1986) Typical and atypical antipsychotic occupancy of D2 and S2 receptors: an autoradiographic analysis in rat brain. Brain Res. Bull., 16, 517-525.
2. Arnt, J. (1995) Differential effects of classical and newer antipsychotics on the hypermofility induced by two dose levels of d-amphetamine. Eur. J. Pharmacol., 283, 55-62.
3. Arnt, J. & Skarsfeldt, T. (1998) Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology, 18, 63-101.
4. Bai, O., Wei, Z.L., Lu, W., Bowen, R., Keegan, D. & Li, X.M. (2002) Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. J. Neurosci. Res., 69, 278-283.
5. Behl, C., Lezoualc'h, F., Widmann, M., Rupprecht, F. & Holsboer, F. (1996) Oxidative stress-resistant cells are protected against haloperidol toxicity. Brain Res., 717, 193-195.
6. Behl, C., Rupprecht, R., Skutella, T. & Holsboer, F. (1995) Haloperidol-induced cell death-mechanism and protection with vitamin E in vitro. Neuroreport, 7, 360-364.
7. Brunello, N., Masotto, C., Steardo, L., Markstein, R. & Racagni, G. (1995) New insights into the biology of schizophrenia through the mechanism of action of clozapine. Neuropsychopharmacology, 13, 177-213.
8. Cadet, J.L. & Kahler, L.A. (1994) Free radical mechanisms in schizophrenia and tardive dyskinesia. Neurosci. Behav. Res., 18, 457-467.
9. Cadet, J.L., Lohr, J.B. & Jeste, D.V. (1986) Free radicals and tardive dyskinesia. Trends Neurosci., 3, 107-108.
10. + neurotoxicity on NGF-differentiated PC12 cells. Cell Biol. Int., 19, 687-693.
11. Casey, D.E. (2000) Tardive dyskinesia: pathophysiology and animal models. J. Clin. Psychiat., 61, 5-9.
12. Cassarino, D.S., Fall, C.P., Smith, T.S. & Bennett, J.P. Jr (1998) Pramipexole reduces reactive oxygen species production in vivo and in vitro and inhibits the mitochondrial permeability transition produced by the parkinsonian neurotoxin methylpyridinium iota. J. Neurochem., 71, 295-301.
13. +-induced apoptosis depends on mitochondrial membrane potential and ATP synthase. Biochem. Biophys. Res. Commun., 257, 440-447.
14. Cleeter, M.W., Cooper, J.M. & Schapira, H.V. (1992) Irreversible inhibition of mitochondrial complex I by I-methyl-4phenylpyridinidium: evidence for free radical involvement. J. Neurochem., 58, 786-789.
15. Dipasquale, B., Marini, A.M. & Youle, R.J. (1991) Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinum in neurons. Biochem. Biophys. Res. Commum., 181, 1442-1448.
16. Du, Y., Dodel, R.C., Bales, K.R., Jemmerson, R., Hamilton-Byrd, E. & Paul, S.M. (1997) Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons. J. Neurochem., 69, 1382-1388.
17. Elkashef, A.M. & Wyatt, R.J. (1999) Tardive dyskinesia: possible involvement of free radicals and treatment with vitamin E. Schizophr. Bull., 25, 731-740.
18. Farde, L., Nordström, A.L., Wiesel, F.A., Pauli, S., Halldin, C. & Sedvall, G. (1992) Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classic neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch. General Psychiatry, 49, 538-544.
19. Greene, L.A. & Rein, G. (1977) Release, storage and uptake of catecholamine by a clonal cell line of nerve growth factor (NGF) responsive phenochromocytoma cells. Brain Res., 129, 247-263.
20. Greene, L.A. & Tischler, A. (1982) PC12 pheochromocytoma cultures in neurobiological research. Adv. Cell. Neurobiol., 3, 373-414.
21. Grollman, A.P. & Moriya, M. (1993) Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet., 9, 246-249.
22. He, B., Qing, H. & Kow, Y.W. (2000) Deoxyxanthasine in DNA in Escherichia coli endonuclease V. Mutation Res., 459, 109-114.
23. Iwata, E., Miyazaki, I., Asanuma, M, Iida, A. & Ogawa, N. (1998) Protective effects of nicergoline against hydrogen peroxide toxicity in rat neuronal cell line. Neurosci. Lett., 251, 49-52.
24. Kapur, S., Zipursky, R.B. & Remington, G. (1999) Comparison of the 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia: clinical and theoretical implications. Am. J. Psychiatry, 156, 286-293.
25. Kinon, B.J. & Lieberman, J.A. (1996) Mechanisms of action of atypical antipsychotic drugs: a critical analysis. Psychopharmacology (Berl.), 124, 2-34.
26. Li, X.M., Chlan-Fourney, J., Juorio, A.V., Bennett, V.L., Shrikhande, S., Keegan, D.L., Qi, J. & Boulton, A.A. (1999) Differential effects of olanzapine on the gene expression of superoxide dismutase and the low affinity nerve growth factor receptor. J. Neurosci. Res., 56, 72-75.
27. Li, X.M., Juorio, A.V., Qi, J. & Boulton, A.A. (1998) 1-Deprenyl potentiates NGF-induced changes in superoxide dismutase mRNA in PC12 cells. J. Neurosci. Res., 53, 235-238.
28. Li, X.H., Song, L. & Jope, R.S. (1996) Cholinergic stimulation of AP-1 and NFκB transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: relationship to phosphoinositide hydrolysis. J. Neurosci., 16, 5914-5922.
29. Lim, C.S., Lee, J.C., Kim, S.D., Chang, D.J. & Kaang, B.K. (2002) Hydrogen peroxide-induced cell death in cultured aplysia sensory neurons. Brain Res., 941, 137-145.
30. Mahadik, S.P., Evans, D. & Lal, H. (2001) Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry, 25, 463-493.
31. i values. J. Pharmacol. Exp. Ther., 251, 238-246.
32. Nicklas, W.J., Vyas, L. & Heikkila, R.E. (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci., 36, 2503-2508.
33. Noh, J.S., Kang, H.J., Kim, E.Y., Sohn, S., Chung, Y.K., Kim, S.U. & Gwag, B.J. (2000) Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH2-terminal protein kinase. J. Neurochem., 75, 2327-2334.
34. Poirier. J., Donaldson, J. & Barbeau, A. (1985) The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals. Biochem. Biophys. Res. Commun., 128, 25-33.
35. Post, A., Holsboer, F. & Behl, C. (1998) induction of NF-κB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-κB and neuroprotection by antioxidants. J. Neurosci., 18, 8236-8246.
36. +. Biochem. Biophys. Res. Commun., 134, 743-748.
37. +. Biochem. Biophys. Res. Commun., 189, 47-52.
38. Sagara, Y. (1998) Induction of reactive oxygen species in neurons by haloperidol. J. Neurochem., 71, 1002-1012.
39. Salinas, M., Martin, D., Alvarez, A. & Cuadrado, A. (2001) Akt1/PKBα protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals. Mol. Cell. Neurosci., 17, 67-77.
40. Schubert, D. & Klier, F.G. (1977) Storage and release of acetylcholine by a clonal cell line. Proc. Natl. Acad. Sci. USA, 74, 5148-5188.
41. Seeman, P. & Tallerico, T. (1999) Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinic relapse upon drug withdrawal of clozapine or quetiapine. Am. J. Psychiatry, 156, 876-884.
42. Shadach, E., Gaisler, I., Schiller, D. & Weiner, I. (2000) The latent inhibition model dissociates between clozapine, haloperidol, and ritanserin. Neuropsychopharmacology, 23, 151-161.
43. Shivakumar, B.R. & Ravindranath, V. (1992) Oxidative stress induced by administration of the neuroleptic drug haloperidol is attenuated by higher doses of haloperidol. Brain Res., 595, 256-262.
44. Shivakumar, B.R. & Ravindranath, V. (1993) Oxidative stress and thiol modification induced by chronic administration of haloperidol. J. Pharmacol. Exp. Ther., 3, 1137-1141.
45. Singer, T.P., Castagnoli, N., Ramsay, R.R. & Trevoor, A.J. (1987) Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Neurochem., 49, 1-8.
46. Stefanis, L., Burke, R.E. & Greene, L.A. (1997) Apoptosis in neurodegenerative disorders. Curr. Opin. Neurol., 19, 299-305.
47. Tipton, K.F. & Singer, T.P. (1993) Advances in our understanding of the mechanism of the cytotoxicity of MPTP and related compounds. J. Neurochem., 61, 1191-1206.
48. Wei, Z. & Li, X.M. (2002) Neuroprotective effects of olanzapine on PC 12 ceils exposed to hydrogen peroxide and β-amyloid peptide. Neurobiology of Aging, 23, No. 1S, S399.
49. Wyatt, R.J. & Henter, I.D. (1998) The effects of early and sustained intervention on the long-term morbidity of schizophrenia. J. Psychiatr. Res., 32, 169-177.
50. Xu, H., Qing, H., Lu, W., Keegan, D., Richardson, J.S., Chlan-Foumey, J. & Li, X.M. (2002) Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci. Lett., 321, 65-68.
51. Yokoyama, H., Kasai, N., Ueda, Y., Niwa, R., Konaka, R., Mori, N., Tsuchihashi, N., Matsue, T., Ohya-Nishiguchi, H. & Kamada, H. (1998) In vivo analysis of hydrogen peroxide and lipid radicals in the striatum of rats under long-term administration of a neuroleptic. Free Rad. Biol. Med., 24, 1056-1060.