Foundation review: A series of case studies: Practical methodology for identifying antinociceptive multi-target drugs

Drug Discovery Today

Volumn 17, Issue 9-10, 2012, Pages 425-434

  Pang, Min Hee ^a   Kim, Yuntae ^b   Jung, Kyung Woon ^c   Cho, Sunyoung ^a   Lee, Doo H ^a  

^a Vivozon Inc   (South Korea)

^b Seoul National University   (South Korea)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 [3 (TRIFLUOROMETHYL) 2 PYRIDINYL] N [5 (TRIFLUOROMETHYL) 2 PYRIDINYL] 1 PIPERAZINECARBOXAMIDE; ACETYLSALICYLIC ACID; ALFUZOSIN; AMITRIPTYLINE; ANALGESIC AGENT; ANTIDEPRESSANT AGENT; ANTINOCICEPTIVE AGENT; ARIPIPRAZOLE; AZD 1386; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DULOXETINE; GABAPENTIN; IBUPROFEN; KETANSERIN; L 741626; METFORMIN; MEXILETINE; N [4 [6 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINYLOXY]BENZOTHIAZOL 2 YL]ACETAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OLANZAPINE; OMEGA CONOTOXIN MVIIA; OPIATE; PREGABALIN; QUETIAPINE; RISPERIDONE; SALICYLIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST; VENLAFAXINE; VVZ 149; VVZ 178;

DRUG COST; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SAFETY; EX VIVO STUDY; HUMAN; HYPERTHERMIA; LONG TERM POTENTIATION; NEUROPATHIC PAIN; NONHUMAN; REVIEW; SPINAL CORD; TREATMENT FAILURE; ANIMAL; DISEASE MODEL; DRUG DESIGN; DRUG EFFECT; PAIN; PATHOPHYSIOLOGY; RAT;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; DRUG DESIGN; HUMANS; PAIN; RATS; SPINAL CORD;

EID: 84862784079     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.01.003     Document Type: Review

References (64)

1. T. Korcsmaros How to design multi-target drugs: target search options in cellular networks Expert Opin. Drug Discov. 2 2007 1 10
2. F. Sams-Dodd Target-based drug discovery: is something wrong? Drug Discov. Today 10 2005 139 147
3. P. Csermely The efficiency of multi-target drugs: the network approach might help drug design Trends Pharmacol. Sci. 26 2005 178 182
4. N.M. Rupniak Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580 Br. J. Pharmacol. 110 1993 1607 1613
5. Y.I. Garces Lack of potent antinociceptive activity by substance P antagonist CP-96,345 in the rat spinal cord Life Sci. 52 1993 353 360
6. R.A. Dionne The substance P receptor antagonist CP-99,994 reduces acute postoperative pain Clin. Pharmacol. Ther. 64 1998 562 568
7. D.J. Goldstein Study of the analgesic effect of lanepitant in patients with osteoarthritis pain Clin. Pharmacol. Ther. 67 2000 419 426
8. G.R. Zimmermann Multi-target therapeutics: when the whole is greater than the sum of the parts Drug Discov. Today 12 2007 34 42
9. S. Ohlson Designing transient binding drugs: a new concept for drug discovery Drug Discov. Today 13 2008 433 439
10. W. Raasch Biological significance of agmatine, an endogenous ligand at imidazoline binding sites Br. J. Pharmacol. 133 2001 755 780
11. C.A. Fairbanks Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury Proc. Natl. Acad. Sci. U.S.A. 97 2000 10584 10589
12. S.I. Berger, and R. Iyengar Network analyses in systems pharmacology Bioinformatics 25 2009 2466 2472
13. Y.A. Kolesnikov The synergistic analgesic interactions between hydrocodone and ibuprofen Anesth. Analg. 97 2003 1721 1723
14. R. Morphy From magic bullets to designed multiple ligands Drug Discov. Today 9 2004 641 651
15. R.W. Teasell A systematic review of pharmacologic treatments of pain after spinal cord injury Arch. Phys. Med. Rehabil. 91 2010 816 831
16. B.T. Priest, and G.J. Kaczorowski Blocking sodium channels to treat neuropathic pain Expert Opin. Ther. Targets 11 2007 291 306
17. N.R. Gavva Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans Pain 136 2008 202 210
18. M. Cui TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists J. Neurosci. 26 2006 9385 9393
19. N. Khairatkar-Joshi, and A. Szallasi TRPV1 antagonists: the challenges for therapeutic targeting Trends Mol. Med. 15 2009 14 22
20. S.G. Lehto Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H- inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats J. Pharmacol. Exp. Ther. 326 2008 218 229
21. R. Hill NK1 (substance P) receptor antagonists - why are they not analgesic in humans? Trends Pharmacol. Sci. 21 2000 244 246
22. E.J. Rahn, and A.G. Hohmann Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside Neurotherapeutics 6 2009 713 737
23. C.J. Woolf, and Q. Ma Nociceptors - noxious stimulus detectors Neuron 55 2007 353 364
24. W.D. Snider, and S.B. McMahon Tackling pain at the source: new ideas about nociceptors Neuron 20 1998 629 632
25. J.M. Braz Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor Neuron 47 2005 787 793
26. M. Tominaga Peripheral nociceptors Molecular Pain 2007 Springer New York pp. 247-263
27. T. Hucho, and J.D. Levine Signaling pathways in sensitization: toward a nociceptor cell biology Neuron 55 2007 365 376
28. S. Stahl Describing an atypical antipsychotic: receptor binding and its role in pathophysiology Prim. Care Companion J. Clin. Psychiatry 5 Suppl. 3 2003 9 13
29. S. Kapur Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia Am. J. Psychiatry 156 1999 286 293
30. T.L. Yaksh An automated flinch detecting system for use in the formalin nociceptive bioassay J. Appl. Physiol. 90 2001 2386 2402
31. J. Qiu Debates on translational research: a balancing act Lancet Neurol. 6 2007 208 209
32. G. Remington From mice to men: what can animal models tell us about the relationship between mental health and physical activity? Ment. Health Phys. Act. 2 2009 10 15
33. A. Latremoliere, and C.J. Woolf Central sensitization: a generator of pain hypersensitivity by central neural plasticity J. Pain 10 2009 895 926
34. R.R. Ji Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 26 2003 696 705
35. C.J. Woolf Evidence for a central component of post-injury pain hypersensitivity Nature 306 1983 686 688
36. C.J. Woolf Central sensitization: implications for the diagnosis and treatment of pain Pain 152 2011 2 15
37. P.W. Mantyh, and S.P. Hunt Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity Trends Neurosci. 27 2004 582 584
38. J. Sandkuhler Understanding LTP in pain pathways Mol. Pain 3 2007 9
39. S. Chemla, and F. Chavane Voltage-sensitive dye imaging: technique review and models J. Physiol. Paris 104 2010 40 50
40. R. Fujii Imaging of molecular dynamics regulated by electrical activities in neural circuits and in synapses Neurosignals 16 2008 260 277
41. H. Maeda Optical and electrophysiological recordings of corticospinal synaptic activity and its developmental change in in vitro rat slice co-cultures Neuroscience 150 2007 829 840
42. T. Tominaga Quantification of optical signals with electrophysiological signals in neural activities of Di-4-ANEPPS stained rat hippocampal slices J. Neurosci. Methods 102 2000 11 23
43. J.P. Martin The globus pallidus in post-encephalitic parkinsonism J. Neurol. Sci. 2 1965 344 365
44. Q.S. Chen Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides J. Neurosci. Res. 60 2000 65 72
45. H. Ikeda Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia Science 299 2003 1237 1240
46. H. Ikeda Optical responses evoked by single-pulse stimulation to the dorsal root in the rat spinal dorsal horn in slice Brain Res. 812 1998 81 90
47. S.H. Kim, and J.M. Chung An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Pain 50 1992 355 363
48. D.H. Lee The role of uninjured nerve in spinal nerve ligated rats points to an improved animal model of neuropathic pain Eur. J. Pain 7 2003 473 479
49. S.R. Chaplan Quantitative assessment of tactile allodynia in the rat paw J. Neurosci. Methods 53 1994 55 63
50. D. Dubuisson, and S.G. Dennis The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats Pain 4 1977 161 174
51. H.U. Zeilhofer The glycinergic control of spinal pain processing Cell Mol. Life Sci. 62 2005 2027 2035
52. T. Dohi Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain Pharmacol. Ther. 123 2009 54 79
53. Y. Nishikawa Blockade of glycine transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain J. Pharmacol. Sci. 112 2010 352 360
54. K. Morita Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice J. Pharmacol. Exp. Ther. 326 2008 633 645
55. M.P. Abbracchio Purinergic signalling in the nervous system: an overview Trends Neurosci. 32 2009 19 29
56. J. Barclay Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain J. Neurosci. 22 2002 8139 8147
57. K. Wirkner P2X3 receptor involvement in pain states Mol. Neurobiol. 36 2007 165 183
58. J. Van Steenwinckel The 5-HT2A receptor is mainly expressed in nociceptive sensory neurons in rat lumbar dorsal root ganglia Neuroscience 161 2009 838 846
59. S.B. McMahon Inflammatory mediators and modulators of pain S.B. McMahon, Pain 2006 Elsevier 49 72
60. M.J. Millan Descending control of pain Prog. Neurobiol. 66 2002 355 474
61. K. Okamoto 5-HT2A receptor subtype in the peripheral branch of sensory fibers is involved in the potentiation of inflammatory pain in rats Pain 99 2002 133 143
62. V.J. Aloyo, and J.A. Harvey Antagonist binding at 5-HT(2A) and 5-HT(2C) receptors in the rabbit: high correlation with the profile for the human receptors Eur. J. Pharmacol. 406 2000 163 169
63. E.A. Pehek Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex Neuropsychopharmacology 31 2006 265 277
64. W.L. Caulfield The first potent and selective inhibitors of the glycine transporter type 2 J. Med. Chem. 44 2001 2679 2682