Blockade of glycine transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain

Journal of Pharmacological Sciences

Volumn 112, Issue 3, 2010, Pages 352-360

  Nishikawa, Yukitoshi ^a   Sasaki, Atsushi ^a   Kuraishi, Yasushi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Dynamic allodynia; Glycine receptor; Glycine transporter; Herpetic pain; Postherpetic neuralgia

Indexed keywords

ALX 1393; ANALGESIC AGENT; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1 SUBUNIT; GLYCINE RECEPTOR ALPHA3 SUBUNIT; GLYCINE TRANSPORTER 1; GLYCINE TRANSPORTER 2; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SARCOSINE; STRYCHNINE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG PROTEIN BINDING; FEMALE; GENE EXPRESSION; HERPES SIMPLEX VIRUS; INOCULATION; LUMBAR SPINAL CORD; MOUSE; NONHUMAN; PAIN ASSESSMENT; POSTHERPETIC NEURALGIA; PROTEIN EXPRESSION; SPINAL CORD DORSAL HORN;

EID: 77950675140     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.09351FP     Document Type: Article

References (44)

1. Loeser JD. Herpes zoster and postherpetic neuralgia. Pain. 1986; 25:149-164.
2. Argoff CE, Katz N, Backonja M. Treatment of postherpetic neuralgia: a review of therapeutic options. J Pain Symptom Manage. 2004;28:396-411.
3. Pappagallo M, Oaklander AL, Quatrano Piacentini AL, Clark MR, Raja SN. Heterogenous patterns of sensory dysfunction in postherpetic neuralgia suggest multiple pathophysiologic mechanisms. Anesthesiology. 2000;92:691-698.
4. Ochoa JL, Yarnitsky D. Mechanical hyperalgesias in neuropathic pain patients: dynamic and static subtypes. Ann Neurol. 1993;33: 465-472.
5. Koltzenburg M, Lundberg LE, Torebjörk HE. Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain. 1992;51:207-219.
6. Takasaki I, Andoh T, Shiraki K, Kuraishi Y. Allodynia and hyperalgesia induced by herpes simplex virus type-1 infection in mice. Pain. 2000;86:95-101.
7. Takasaki I, Sasaki A, Andoh T, Nojima H, Shiraki K, Kuraishi Y. Effects of analgesics on delayed postherpetic pain in mice. Anes- thesiology. 2002;96:1168-1174.
8. Sasaki A, Serizawa K, Andoh T, Shiraki K, Takahata H, Kuraishi Y. Pharmacological differences between static and dynamic allodynia in mice with herpetic or postherpetic pain. J Pharmacol Sci. 2008;108:266-273.
9. Takasaki I, Andoh T, Nitta M, Takahata H, Nemoto H, Shiraki K, et al. Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. Jpn J Pharmacol. 2000;83:319-326.
10. Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron. 2006;52:77-92.
11. Nishikawa Y, Sasaki A, Andoh T, Nojima H, Shiraki K, Kuraishi Y. Modality-specific hyperexcitability of dorsal horn neurons to mechanical stimuli in herpetic mice. Neuroreport. 2009;20:1077-1080.
12. Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet. 1999;353:1959-1964.
13. Mitchell K, Spike RC, Todd AJ. An immunocytochemical study of glycine receptor and GABA in laminae I-III of rat spinal dorsal horn. J Neurosci. 1993;13:2371-2381.
14. Becker CM, Hoch W, Betz H. Glycine receptor heterogeneity in rat spinal cord during postnatal development. EMBO J. 1988;7: 3717-3726.
15. Harvey RJ, Depner UB, Wässle H, Ahmadi S, Heindl C, Reinold H, et al. GlyR I{ogonek} 3: an essential target for spinal PGE2 -mediated inflammatory pain sensitization. Science. 2004;304:884-887.
16. Sherman SE, Luo L, Dostrovsky JO. Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus. J Neurophysiol. 1997;78:628-637.
17. Sivilotti L, Woolf CJ. The contribution of GABA A and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J Neurophysiol. 1994;72:169-179.
18. Eulenburg V, Armsen W, Betz H, Gomeza J. Glycine transporters: essential regulators of neurotransmission. Trends Biochem Sci. 2005;30:325-333.
19. Smith KE, Borden LA, Hartig PR, Branchek T, Weinshank RL. Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors. Neuron. 1992;8:927-935.
20. Aragón C, López-Corceura B. Structure, function and regulation of glycine neurotransporters. Eur J Pharmacol. 2003;479:249-262.
21. Hermanns H, Muth-Selbach U, Williams R, Krug S, Lipfert P, Werdehausen R, et al. Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain. Neurosci Lett. 2008;445:214-219.
22. Morita K, Motoyama N, Kitayama T, Morioka N, Kifune K, Dohi T. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J Pharmacol Exp Ther. 2008;326:633-645.
23. Tanabe M, Takasu K, Yamaguchi S, Kodama D, Ono H. Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment. Anesthesiology. 2008; 108:929-937.
24. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109-110.
25. Xu TX, Gong N, Xu TL. Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission. Neuroreport. 2005;16: 1227-1231.
26. Hylden JL, Wilcox GL. Intrathecal morphine in mice: a new technique. Eur J Pharmacol. 1980;67:313-316.
27. Minami T, Matsumura S, Okuda-Ashitaka E, Shimamoto K, Sakimura K, Mishina M. Characterization of the glutamatergic system for induction and maintenance of allodynia. Brain Res. 2001;895:178-185.
28. Sasaki A, Mabuchi T, Serizawa K, Takasaki I, Andoh T, Shiraki K, et al. Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice. Neuroscience. 2007; 150:459-466.
29. Legendre P. The glycinergic inhibitory synapse. Cell Mol Life Sci. 2001;58:760-793.
30. Johnson JW, Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987;325:529-531.
31. Nong Y, Huang YQ, Ju W, Kalia LV, Ahmadian G, Wang YT, et al. Glycine binding primes NMDA receptor internalization. Nature. 2003;422:302-307.
32. Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O. Allodynia evoked by intrathecal administration of prostaglandin E 2 to conscious mice. Pain. 1994;57:217-223.
33. Zafra F, Aragón C, Olivares L, Danbolt NC, Giménez C, Storm-Mathisen J. Glycine transporters are differentially expressed among CNS cells. J Neurosci. 1995;15:3952-3969.
34. Zafra F, Gomeza J, Olivares L, Aragón C, Giménez C. Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS. Eur J Neurosci. 1995;7: 1342-1352.
35. Jursky F, Nelson N. Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor. J Neurochem. 1995;64:1026-1033.
36. Bradaïa A, Schilichter R, Trouslard J. Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J Physiol. 2004;559:169-186.
37. Whitehead KJ, Pearce SM, Walker G, Sundaram H, Hill D, Bowery NG. Positive N-methyl-D -aspartate receptor modulation by selective glycine transporter-1 inhibition in the rat dorsal spinal cord in vivo. Neuroscience. 2004;126:381-390.
38. Gomeza J, Ohno K, Hülsmann S, Armsen W, Eulenburg V, Richter DW, et al. Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality. Neuron. 2003;40:797-806.
39. Jursky F, Nelson N. Developmental expression of the glycine transporters GLYT1 and GLYT2 in mouse brain. J Neurochem. 1996;67:336-344.
40. Roux MJ, Supplisson S. Neuronal and glial glycine transporters have different stoichiometries. Neuron. 2000;25:373-383.
41. Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Xu L, et al. Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur J Neurosci. 2005;22:1445-1454.
42. Wilson JA, Garry EM, Anderson HA, Rosie R, Colvin LA, Mitchell R, et al. NMDA receptor antagonist treatment at the time of nerve injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviors to subsequently administered NMDA receptor antagonists. Pain. 2005;117:421-432.
43. Cavaliere C, Cirillo G, Rosaria Bianco M, Rossi F, De Novellis V, Maione S, et al. Gliosis alters expression and uptake of spinal glial amino acid transporters in a mouse neuropathic pain model. Neuron Glia Biol. 2007;3:141-153.
44. Hanley JG, Jones EM, Moss SJ. GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. J Biol Chem. 2000;275:840-846.