A novel series of benzimidazole NR2B-selective NMDA receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2620-2623

  Davies, David J ^a   Crowe, Matthew ^a   Lucas, Nolwenn ^a   Quinn, Joanna ^a   Miller, David D ^a   Pritchard, Sara ^a   Grose, David ^a   Bettini, Ezio ^b   Calcinaghi, Novella ^b   Virginio, Caterina ^b   Abberley, Lee ^a   Goldsmith, Paul ^a   Michel, Anton D ^a   Chessell, Iain P ^a   Kew, James N C ^a   Miller, Neil D ^a   Gunthorpe, Martin J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GSK   (Italy)

Author keywords

Depression; Drug discovery; Glutamate; Ion channel; NMDA; NR2B; Pain

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RADIOLIGAND;

ARTICLE; CHRONIC PAIN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; LIGAND BINDING; MAJOR DEPRESSION; MIGRAINE; NERVE DEGENERATION; NONHUMAN; RAT;

ANALGESICS; ANTIDEPRESSIVE AGENTS; BENZIMIDAZOLES; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862783582     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.108     Document Type: Article

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