Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways

Toxicology in Vitro

Volumn 26, Issue 5, 2012, Pages 649-655

  Chen, Xue mei ^a,b,c   Liu, Jun ^a   Wang, Tao ^a   Shang, Jing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b XINJIANG UNIVERSITY   (China)

^c Xinjiang Huashidan Pharmaceutical Research Co LTD   (China)

Author keywords

Apoptosis; Colchicine; L 02; Mechanism

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CASPASE 8; CASPASE 9; COLCHICINE; LACTATE DEHYDROGENASE; LIPOCORTIN 5; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL LOSS; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME RELEASE; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MITOCHONDRION; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL CYCLE; CELL LINE; COLCHICINE; GOUT SUPPRESSANTS; HUMANS; L-LACTATE DEHYDROGENASE; LIVER; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84862781230     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.01.024     Document Type: Article

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