A trial of three regimens for primary amyloidosis: Colchicine alone, melphalan and prednisone, melphalan, prednisone, and colchicine

New England Journal of Medicine

Volumn 336, Issue 17, 1997, Pages 1202-1207

  Kyle, Robert A ^a   Gertz, Morie A ^a   Greipp, Philip R ^a   Witzig, Thomas E ^a   Lust, John A ^a   Lacy, Martha Q ^a   Therneau, Terry M ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; COLCHICINE; IMMUNOGLOBULIN LIGHT CHAIN; MELPHALAN; PREDNISONE; SERUM AMYLOID P;

ACUTE LEUKEMIA; ADULT; AGED; AMYLOIDOSIS; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HEART DISEASE; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MYELODYSPLASIA; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL;

EID: 0030895545     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199704243361702     Document Type: Article

References (11)

1. Kyle RA, Bayrd ED. Amyloidosis: review of 236 cases. Medicine (Baltimore) 1975;54:271-99.
2. Kyle RA, Greipp PR. Amyloidosis (AL): clinical and laboratory features in 229 cases. Mayo Clin Proc 1983;58:665-83.
3. Kyle RA, Gertz MA. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin Hematol 1995;32:45-59.
4. Kyle RA, Greipp PR. Primary systemic amyloidosis: comparison of melphalan and prednisone versus placebo. Blood 1978;52:818-27.
5. Cohen AS, Rubinow A, Anderson JJ, et al. Survival of patients with primary (AL) amyloidosis: colchicine-treated cases from 1976 to 1983 compared with cases seen in previous years (1961 to 1973). Am J Med 1987;82:1182-90.
6. Kyle RA, Greipp PR, Garton JP, Gertz MA. Primary systemic amyloidosis: comparison of melphalan/prednisone versus colchicine. Am J Med 1985;79:708-16.
7. Skinner M, Anderson J, Simms R, et al. Treatment of 100 patients with primary amyloidosis: a randomized trial of melphalan, prednisone, and colchicine versus colchicine only. Am J Med 1996;100:290-8.
8. 123I-labeled serum amyloid P component. N Engl J Med 1990;323:508-13.
9. Comenzo RL, Vosburgh E, Sarnacki DL, et al. High-dose melphalan with blood stem cell support for AL amyloidosis. Blood 1995;86:Suppl 1:206A. abstract.
10. Dhodapkar M, Jagannath S, Vesole D, et al. Efficacy of pulse dexamethasone (DEX) plus maintenance alpha interferon (IFN) in primary systemic amyloidosis (AL). Blood 1995;86:Suppl 1:442A. abstract.
11. Gianni L, Bellotti V, Gianni AM, Merlini G. New drug therapy of amyloidoses: resorption of AL-type deposits with 4′-iodo-4′-deoxydoxorubicin. Blood 1995;86:855-61.